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Entry version 49 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Kinase non-catalytic C-lobe domain containing 1

Gene

KNDC1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kinase non-catalytic C-lobe domain containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNDC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:55913 KNDC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7CJ89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020221 Expressed in 2 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 217KINDInterPro annotationAdd BLAST181
Domaini441 – 605KINDInterPro annotationAdd BLAST165
Domaini1253 – 1381N-terminal Ras-GEFInterPro annotationAdd BLAST129
Domaini1474 – 1725Ras-GEFInterPro annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 277DisorderedSequence analysisAdd BLAST60
Regioni385 – 439DisorderedSequence analysisAdd BLAST55
Regioni688 – 874DisorderedSequence analysisAdd BLAST187
Regioni963 – 1069DisorderedSequence analysisAdd BLAST107
Regioni1076 – 1095DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1144 – 1164Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi403 – 417PolyampholyteSequence analysisAdd BLAST15
Compositional biasi696 – 715PolyampholyteSequence analysisAdd BLAST20
Compositional biasi826 – 840Pro-richSequence analysisAdd BLAST15
Compositional biasi963 – 990PolarSequence analysisAdd BLAST28
Compositional biasi1038 – 1053PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II5U Eukaryota
ENOG410XQ1A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011408

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7CJ89

TreeFam database of animal gene trees

More...
TreeFami
TF336009

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR011019 KIND_dom
IPR029899 KNDC1
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21560 PTHR21560, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16474 KIND, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00750 KIND, 2 hits
SM00147 RasGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366 SSF48366, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51377 KIND, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F7CJ89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAMEPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDSGL
60 70 80 90 100
SEQEAWAVCL ECSLSMRSVA HSAIFQTLCI TPDTLAFNTS GNVCFMEQLS
110 120 130 140 150
DDPEGAFVPP EFDVTGNTFE AHIYSLGATL KAALEYVAEP EPEPRLSRDL
160 170 180 190 200
EVLLGQMQAE DPGDRPDLES IIALCEEKMQ FTSSCRLCRS LSAVGRRVLS
210 220 230 240 250
LESFGAFQDL SESAWRGRLA PRSAGPRRQP GDASADPEVP ACPEGLPQTP
260 270 280 290 300
ACKGPEHPGT LLSKPLLPEP VRNGESHGRE GLASLILDTQ RPLGDLDRGF
310 320 330 340 350
LERSRLRKVQ TFPRLLPEGP EASALCLSLT STKNQLPTPE LLPPDPRKAF
360 370 380 390 400
SEEKNGLSSF KAQLKSGLWP EPEPELQWAG ALGAGHGRDR VAGAPSPVEE
410 420 430 440 450
SPPPHPEDPH EAGQDPRTPG SDKGILDGAG EPGSTATEQG VSLQDLLSKL
460 470 480 490 500
GRPFREYELW ALSHACLSTL RTHGQHPACL CLDSVLVAED GAVLFGPPPA
510 520 530 540 550
NGAYNSFFLA PEVAEQKLVT EKASVYCVAA VLWTAAKFSI PRDRKLALPR
560 570 580 590 600
RLKTLLLDMA RRSTQERLSA AEAIKICRTY LLQRGMDSRK ILAHLRASTC
610 620 630 640 650
QVYQEEETIG LQNAFSVVEL NPSTAPAPGP SSGFVRIGDT RLIAVQGPVP
660 670 680 690 700
GQPSCCEEGM MLPEAFTSAA THFKPIVLAP DAGVARDALS LSSGPAERPE
710 720 730 740 750
EKRGQLDREG DGKQTPEAHG VAASLKAPEQ QAPGPRPQGA APEPLQDSAQ
760 770 780 790 800
GGPCSLPLSP ASPPEGLSLA KAQMPPPDKG LDELVLPGGS SGGLGPGAPE
810 820 830 840 850
PIAQHGLCHP AKPPRKKATE GPGQKPEDPP LAPQGPSPAT ASPDSPRGTP
860 870 880 890 900
IMGRDDQGHP EQPQPAGRKL CASNVDTSPL RKRTGCLSLQ EATRLIQEEF
910 920 930 940 950
AFDGYLDNGL EALIMGEYIY ALKDLTFATF CGAISEKFCD LYWGEKLLQN
960 970 980 990 1000
LFKVVNGRTS PLENASEEAG SQPEGSGRTR APSSCSPSGK RPSLHRAGKE
1010 1020 1030 1040 1050
KPASGRVGRA PCAPPSLSDV DSDELSRGNF EVGFRPQKSV RAQRERPPEA
1060 1070 1080 1090 1100
EDRQQGGGPE PAGGASDAEA VAQLPKPEGA GPAVSPGPAE FQSGSPGWGS
1110 1120 1130 1140 1150
AFYEAECFGA DVCSYVAELA RQKAGGAPDA QSPQELEQQL VIEKRNYRKT
1160 1170 1180 1190 1200
LKFYQKLLQK EKRSKGSEVK TMLSKLKGQL EEMKSKMQFL GLVKKYLQVM
1210 1220 1230 1240 1250
YAERWGLEPC ALPVIVNIAA AHCDTLDFSP LDESSSLIFY NVSKHPHGSR
1260 1270 1280 1290 1300
QRKARVLQAG TPLGLMAYLY SSDAFLEGYV QQFLYTFRYF CTPHDFLHFL
1310 1320 1330 1340 1350
LDRINSTLSR AHQDPTSTFT KIYKRSFCLL QAWVEDCYAV DFTRNAGLLG
1360 1370 1380 1390 1400
RLEDFISSKV LPLDGSAEHL LGLLEVGMDR RAEGAPRSTD LEDPKETEED
1410 1420 1430 1440 1450
TRPLNALCKR LSEDGISRKS FPWRLSRSNG LVLPHKERQY TIASALPKPC
1460 1470 1480 1490 1500
FFEDFYGPYA KASEKGPYFL TEYSTHQLFS QLTLLQQELF QKCHPVHFLN
1510 1520 1530 1540 1550
SRALGVMDKN VAIPKASSSE SLSAKSGSLF LPNYVQDKYL LQLLRSADDV
1560 1570 1580 1590 1600
STWVAAEIVT SHTSKLQVNL LSKFLLIAKS CYEQRNFATA MQILGGLEHL
1610 1620 1630 1640 1650
AVRQSPAWRI LPAKIAEVME ELKAVEVFLK SDSLCLMEGR RFRAQPTLPS
1660 1670 1680 1690 1700
ARLLAMHIQQ LETGGFTMTN GAHRWSKLRN IAKVVSQVHA FQENPYTFAP
1710 1720 1730 1740 1750
DPKLQSHLKQ RIARFSGADI SILAADNRAN FHQITSEKHS RKIQDKLRRM

KATFQ
Length:1,755
Mass (Da):191,349
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i751417BECF013101
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2L5U9A0A3Q2L5U9_HORSE
Kinase non-catalytic C-lobe domain ...
KNDC1
1,764Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000021637; ENSECAP00000017829; ENSECAG00000020221

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF7CJ89

Genome annotation databases

EnsembliENSECAT00000021637; ENSECAP00000017829; ENSECAG00000020221

Organism-specific databases

VGNCiVGNC:55913 KNDC1

Phylogenomic databases

eggNOGiENOG410II5U Eukaryota
ENOG410XQ1A LUCA
GeneTreeiENSGT00390000011408
InParanoidiF7CJ89
TreeFamiTF336009

Gene expression databases

BgeeiENSECAG00000020221 Expressed in 2 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR011019 KIND_dom
IPR029899 KNDC1
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR21560 PTHR21560, 1 hit
PfamiView protein in Pfam
PF16474 KIND, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00750 KIND, 2 hits
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51377 KIND, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CJ89_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CJ89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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