UniProtKB - F7CET7 (F7CET7_HORSE)
Protein
Receptor protein-tyrosine kinase
Gene
KDR
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: InterPro
- cadherin binding Source: Ensembl
- identical protein binding Source: Ensembl
- integrin binding Source: Ensembl
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
- vascular endothelial growth factor-activated receptor activity Source: Ensembl
- vascular endothelial growth factor binding Source: Ensembl
GO - Biological processi
- branching involved in blood vessel morphogenesis Source: Ensembl
- calcium-mediated signaling using intracellular calcium source Source: Ensembl
- cell migration Source: GO_Central
- cellular response to hydrogen sulfide Source: Ensembl
- endothelial cell differentiation Source: GO_Central
- ERK1 and ERK2 cascade Source: Ensembl
- hematopoietic progenitor cell differentiation Source: GO_Central
- multicellular organism development Source: GO_Central
- negative regulation of endothelial cell apoptotic process Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- positive regulation of angiogenesis Source: GO_Central
- positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of focal adhesion assembly Source: Ensembl
- positive regulation of kinase activity Source: GO_Central
- positive regulation of macroautophagy Source: Ensembl
- positive regulation of mitochondrial depolarization Source: Ensembl
- positive regulation of mitochondrial fission Source: Ensembl
- positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of positive chemotaxis Source: Ensembl
- protein autophosphorylation Source: Ensembl
- protein kinase B signaling Source: Ensembl
- regulation of cell shape Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vascular endothelial growth factor receptor-2 signaling pathway Source: Ensembl
- vascular wound healing Source: Ensembl
Keywordsi
Molecular function | Developmental proteinARBA annotation, Kinase, ReceptorUniRule annotationARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Biological process | AngiogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:KDRImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19344, KDR |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Endosome
- early endosome Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell junction Source: UniProtKB-SubCell
- membrane raft Source: Ensembl
- receptor complex Source: GO_Central
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5018790594 | 20 – 1358 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 1339 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000019429, Expressed in chorionic villus and 20 other tissues |
Interactioni
GO - Molecular functioni
- cadherin binding Source: Ensembl
- identical protein binding Source: Ensembl
- integrin binding Source: Ensembl
- vascular endothelial growth factor binding Source: Ensembl
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1280 – 1300 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1286 – 1300 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation
Keywords - Domaini
Immunoglobulin domainUniRule annotationARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156710 |
HOGENOMi | CLU_000288_49_4_1 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009136, VEGFR2_rcpt |
PANTHERi | PTHR24416:SF45, PTHR24416:SF45, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
PRINTSi | PR01834, VEGFRECEPTR2 |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7CET7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESKALLAIA LWLCVETRAA SVGLSSVSLD PPRLSIQKDI LTIMANTTLQ
60 70 80 90 100
ITCRGQRDLD WLWPNTQSGS EKRVEVTECS DGVFCKTLTI PKVIGNDTGA
110 120 130 140 150
YKCFYRDTDT ASVVYVYVQD YRSPFIASVS DQHGVVYITE NKNKTVVIPC
160 170 180 190 200
LGSISNLNVS LCARYPEKRF VPDGNRISWD SKKGFTIPSY MISYAGMVFC
210 220 230 240 250
EAKINDETYQ SIMYIVVVVG YRIYDVVLSP PHEIELSVGE KLVLNCTART
260 270 280 290 300
ELNVGIDFNW EYPSLKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDAVTRS
310 320 330 340 350
DHGMYTCAAS SGLMTKKNST FVRIHEKPFV AFGSGMESSV EATVGDHVRV
360 370 380 390 400
PVKCLGYPPP EIKWYKNGRP IESNHTIKVG HVLTIMEVSE KDTGNYTVIL
410 420 430 440 450
TNPISKEKQS HVVSLVVNVP PQIGEKSLIS PVDSYQYGIT QTLTCTVYAV
460 470 480 490 500
PPPHHIHWYW QLEEECTYKP TQAALMTNPY TCKEWRNVED FQGGNKIEVN
510 520 530 540 550
KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKAGRGE RVISFHVTRG
560 570 580 590 600
PEITLQPDTQ PTEQENVSLW CTADRTTFEN VTWYKLGPQA LPIHAGEVPT
610 620 630 640 650
PVCKNLDALW KMNAVMFSNG TNDILILELQ NASLQDQGDY ICFAQDRKTK
660 670 680 690 700
KRHCVVRQLT VLERMAPMIM GNLENQTTSI GETIEVSCTA SGNPHPQITW
710 720 730 740 750
FKDNETLVED SGIVLKDGNR NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA
760 770 780 790 800
FFIVEGAQEK TNLEVIILVG TAVIAMFFWL LLVIVLRTVK RANGGELKTG
810 820 830 840 850
YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL GRGAFGQVIE
860 870 880 890 900
ADAFGIDKAA TCKTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN
910 920 930 940 950
LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRPGKE
960 970 980 990 1000
YVGEITMDPK RRLDSITSSQ SSASSGFVEE KSLSDVEEEE VSEDLYKNFL
1010 1020 1030 1040 1050
TLEHLICYSF QVAKGMEFLA SRKCIHRDLA ARNILLSEKN VVKICDFGLA
1060 1070 1080 1090 1100
RDIYKDPDYV RKGDARLPLK WMAPETIFDR VYTIQSDVWS FGVLLWEIFS
1110 1120 1130 1140 1150
LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML DCWHGEPNQR
1160 1170 1180 1190 1200
PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS
1210 1220 1230 1240 1250
CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK
1260 1270 1280 1290 1300
VIPDDNQTDS GMVLASEELK TLEDRTKLAP SFSGLMPSKS KESVASEGSN
1310 1320 1330 1340 1350
QTRGRKSFLV WTGLYLLEGE EGRGQRPGRM CFLPSFNCLG SYYTHTHTPW
STGDVCQE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HTL0 | A0A3Q2HTL0_HORSE | Receptor protein-tyrosine kinase | KDR | 1,356 | Annotation score: | ||
A0A3Q2I213 | A0A3Q2I213_HORSE | Receptor protein-tyrosine kinase | KDR | 1,315 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000021639; ENSECAP00000017831; ENSECAG00000019429 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000021639; ENSECAP00000017831; ENSECAG00000019429 |
Organism-specific databases
VGNCi | VGNC:19344, KDR |
Phylogenomic databases
GeneTreei | ENSGT00940000156710 |
HOGENOMi | CLU_000288_49_4_1 |
Gene expression databases
Bgeei | ENSECAG00000019429, Expressed in chorionic villus and 20 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009136, VEGFR2_rcpt |
PANTHERi | PTHR24416:SF45, PTHR24416:SF45, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
PRINTSi | PR01834, VEGFRECEPTR2 |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7CET7_HORSE | |
Accessioni | F7CET7Primary (citable) accession number: F7CET7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |