UniProtKB - F7CE45 (F7CE45_HORSE)
Protein
Submitted name:
Acetyl-CoA acetyltransferase 1
Gene
ACAT1
Organism
Equus caballus (Horse)
Status
Functioni
: Lipid metabolism Pathwayi
This protein is involved in Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 126 | Acyl-thioester intermediateUniRule annotation | 1 | |
Binding sitei | 219 | Coenzyme AUniRule annotation | 1 | |
Binding sitei | 263 | Coenzyme AUniRule annotation | 1 | |
Binding sitei | 284 | Coenzyme AUniRule annotation | 1 | |
Active sitei | 385 | Proton acceptorUniRule annotation | 1 | |
Active sitei | 413 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- acetyl-CoA C-acetyltransferase activity Source: GO_Central
- acetyl-CoA C-acyltransferase activity Source: GO_Central
GO - Biological processi
- fatty acid beta-oxidation Source: GO_Central
Keywordsi
Molecular function | AcyltransferaseUniRule annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Acetyl-CoA acetyltransferase 1Imported |
Gene namesi | Name:ACAT1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:14971, ACAT1 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020128, Expressed in gluteus medius and 22 other tissues |
ExpressionAtlasi | F7CE45, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 298 | Thiolase_NInterPro annotationAdd BLAST | 257 | |
Domaini | 307 – 426 | Thiolase_CInterPro annotationAdd BLAST | 120 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 258 – 260 | Coenzyme A bindingUniRule annotation | 3 |
Sequence similaritiesi
Keywords - Domaini
Transit peptideARBA annotationPhylogenomic databases
GeneTreei | ENSGT01010000222371 |
HOGENOMi | CLU_031026_0_1_1 |
InParanoidi | F7CE45 |
TreeFami | TF300650 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7CE45-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLAALLRG GARGRSPLLR RLAQDIRYVE RGYVSKPTLN EVVIVGAIRT
60 70 80 90 100
PIGSFLGSLS SLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG
110 120 130 140 150
QAPTKQAVLG AGLPVSTPCT TINKVCASGM KAIMMASQNL MCGHQDVMVA
160 170 180 190 200
GGMESMSNVP YIMNRGATPY GGVKLEDLIV KDGLTDVYNK IHMGNCAENT
210 220 230 240 250
AKKLNIARDE QDTFAINSYT RSKAAWEAGK FANEVIPVTV AVKGKPDVVV
260 270 280 290 300
KEDEEYKRVD FSKVPKLKAV FQKENGTVTA ANASTLNDGA AAVVLMTADA
310 320 330 340 350
ARRLNVKPLA RIAAFADAAV EPIDFPIAPA YAVPKVLKDA GLKKEDITMW
360 370 380 390 400
EVNEAFSVVV LANIKMLELD PQKVNINGGA VSLGHPIGMS GARLVVHLTH
410 420
ALKQGEYGLA SICNGGGGAS AILIQKL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H7J7 | A0A3Q2H7J7_HORSE | Acetyl-CoA acetyltransferase 1 | ACAT1 | 398 | Annotation score: | ||
A0A5F5PF20 | A0A5F5PF20_HORSE | Acetyl-CoA acetyltransferase 1 | ACAT1 | 163 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000021659; ENSECAP00000017849; ENSECAG00000020128 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7CE45 |
Genome annotation databases
Ensembli | ENSECAT00000021659; ENSECAP00000017849; ENSECAG00000020128 |
Organism-specific databases
VGNCi | VGNC:14971, ACAT1 |
Phylogenomic databases
GeneTreei | ENSGT01010000222371 |
HOGENOMi | CLU_031026_0_1_1 |
InParanoidi | F7CE45 |
TreeFami | TF300650 |
Gene expression databases
Bgeei | ENSECAG00000020128, Expressed in gluteus medius and 22 other tissues |
ExpressionAtlasi | F7CE45, baseline |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7CE45_HORSE | |
Accessioni | F7CE45Primary (citable) accession number: F7CE45 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |