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Entry version 58 (16 Oct 2019)
Sequence version 2 (09 Jan 2013)
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Protein
Submitted name:

Transcriptional regulating factor 1

Gene

TRERF1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transcriptional regulating factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRERF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9258 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002279 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOANG00000008467 Expressed in 7 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9258.ENSOANP00000013464

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini506 – 533C2H2-typeInterPro annotationAdd BLAST28
Domaini686 – 777ELM2InterPro annotationAdd BLAST92
Domaini792 – 843SANTInterPro annotationAdd BLAST52
Domaini917 – 946C2H2-typeInterPro annotationAdd BLAST30
Domaini989 – 1016C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 35DisorderedSequence analysisAdd BLAST20
Regioni41 – 67DisorderedSequence analysisAdd BLAST27
Regioni271 – 352DisorderedSequence analysisAdd BLAST82
Regioni389 – 429DisorderedSequence analysisAdd BLAST41
Regioni533 – 562DisorderedSequence analysisAdd BLAST30
Regioni863 – 901DisorderedSequence analysisAdd BLAST39
Regioni954 – 986DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1005 – 1032Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 59PolarSequence analysisAdd BLAST19
Compositional biasi271 – 327PolarSequence analysisAdd BLAST57
Compositional biasi389 – 421PolarSequence analysisAdd BLAST33
Compositional biasi538 – 562PolyampholyteSequence analysisAdd BLAST25
Compositional biasi863 – 877AcidicSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4167 Eukaryota
ENOG4110BKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160303

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7CDY5

TreeFam database of animal gene trees

More...
TreeFami
TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448 ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CDY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDQQQLYKA NHTANSNENL YYQPPPLNPL SALGGSLNHN YGTSGMDASQ
60 70 80 90 100
ASPLSPHFPQ DSRDNMALGA KNLGSVDASR QTGWTHVGAG NHVPARNSLP
110 120 130 140 150
NQNVLWSPGG QPDAGEGYQY SYSQANEIRS QKITSGVLHK LDSFTQVFAN
160 170 180 190 200
QNLRIQVNNM AQVLHTQTSV MDGVSDSALR QLLSQKPAEA QAAPPGLPRY
210 220 230 240 250
QPAAQPVHLG FAGSQQKHPA PAGPHSQPHV YYDYQQHLAQ MQVQSVLQPG
260 270 280 290 300
QQQQMQSQQM LPQQMQQAQY YIQQQQQPPG QQRMSMQDMQ QQQARQQQQP
310 320 330 340 350
PPRQCPLQLP QYYQTQPIMQ QQQQQQPQPM PLQPPSYHRD PSQKTVHETH
360 370 380 390 400
PFPQDQTHSV QLIQLGAMPQ YFYQDPQQQQ YSRHLYQQSL LQQQQQQPPD
410 420 430 440 450
EAQQKQYHSD GRTQAGINSH LGIGPSESME DHMGQELIPV GTTIPQRPLL
460 470 480 490 500
AQSGVHLSSK GAQQQSPSAL WPQMHFPDGR TQPISPEPSG QSKGLFLERP
510 520 530 540 550
DAKNRLTCSI CFKEFKSLPA LNGHMRSHGG MRASPGFRQE VSRKHHPSVP
560 570 580 590 600
RTEEQTRPLQ DKKKYRHRPE PLFIPPPTFN LNTSFSGATL YQSQLRSPRI
610 620 630 640 650
LGDHLLDRTH ELPPYTPPPM LSPVRQGSGL FSSVIITTSQ TGSHPQLPLT
660 670 680 690 700
PLTPTPRVLL CRSNSIDGGS VPVTPGPGEQ TVDIEPRINI GSRFQAEIPE
710 720 730 740 750
LQDFTTVDKD PHRATLVWKP WPELENRDVQ QRVENLLNLC CSSALPGGGT
760 770 780 790 800
NSEFALHSLF EAKGDIMAVV ERLLLKKPAR LKCHPLANYH YAGSDKWTSL
810 820 830 840 850
ERKLFSKALA TYSKDFIFVQ KMVKSKTVAQ CVEYYYTWKK IMRLGRKHRT
860 870 880 890 900
RLAEIRDDCL TSGEEEDLEE EDDLEEDRKS IKDESEMQKS PEPPPIPLVA
910 920 930 940 950
PMELPPLQSL VHPSVSFICE MPNCGAVFSS RQALNGHARI HGGTNQVTKT
960 970 980 990 1000
RCAVPPAKQK SGSQSGYCSV KSSPAHSTTS GETDPTNIFP CKECGRVFFK
1010 1020 1030 1040 1050
IKSRNAHMKT HRQQEEQQRQ KAQKAAVAAQ MAATIARTTG PVGHGLIPLD
1060 1070 1080 1090 1100
HLSLIKHVED VDILDDDVVQ ELGGVMGETE VGETDLLLDD EDTDLLPGDT

EL
Length:1,102
Mass (Da):122,896
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCD932EE30A0F5B8
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOANT00000013467; ENSOANP00000013464; ENSOANG00000008467

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000013464

Genome annotation databases

EnsembliENSOANT00000013467; ENSOANP00000013464; ENSOANG00000008467

Phylogenomic databases

eggNOGiKOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00940000160303
InParanoidiF7CDY5
TreeFamiTF106431

Gene expression databases

BgeeiENSOANG00000008467 Expressed in 7 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CDY5_ORNAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CDY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: October 16, 2019
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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