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Entry version 47 (16 Oct 2019)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Gem nuclear organelle-associated protein 5

Gene

gemin5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-191859 snRNP Assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Gem nuclear organelle-associated protein 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gemin5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-981572 gemin5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7CD46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000019404 Expressed in 11 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000042042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 726WD_REPEATS_REGIONInterPro annotationAdd BLAST665
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 106WDPROSITE-ProRule annotationAdd BLAST45
Repeati248 – 271WDPROSITE-ProRule annotationAdd BLAST24
Repeati641 – 683WDPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni718 – 820DisorderedSequence analysisAdd BLAST103
Regioni1365 – 1410DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi721 – 741PolyampholyteSequence analysisAdd BLAST21
Compositional biasi752 – 769PolyampholyteSequence analysisAdd BLAST18
Compositional biasi770 – 785PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJDN Eukaryota
ENOG410XTH3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000088064

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
F7CD46

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLGDHQS

TreeFam database of animal gene trees

More...
TreeFami
TF328886

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CD46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEPDRMLSA SPNWYCSRSS DAAGGLFGFA ARNSVYLLNI NLQEPGFYGS
60 70 80 90 100
GGFVFIFVSG ELVGHTDRVS GFAFSHFSGQ SHLCASSSDD GTVKVWDTQT
110 120 130 140 150
KNTVTEHHLH RSTIAALHWS PLVKDLLVSG DEKGVLVCFW CNRNDSQQFF
160 170 180 190 200
PEPRTIFCLS CSPHKEDIVA IGYKDGMIVL VDISRRGDVL HRLRGHEEEI
210 220 230 240 250
HCLEWSPHAL ECDLQQKLEE TDLICFPPTE INTANGELLP ETENRRCYLA
260 270 280 290 300
SGSKDQTVRI WSASTGKAVT VLKLPYLKRR GGGVDPAIKE RLWLTLHWPP
310 320 330 340 350
GHSTQILSSC FGGELLLWDL TKSGKQKWTL LGTSDGQNHS RIVFNLCSVV
360 370 380 390 400
TEEGKELLLS TSMDRDVKCW DLGSLSCCWS LTSLGGFVYS LAFSPVAAGS
410 420 430 440 450
LAVGVGDSMI RVWNTMSVVN AYDVKTLWQG IRSKVTALSW HPTKEGSLAF
460 470 480 490 500
GTEDGKVGIF EVYISKPPQI SATYHKKTVY SLSWGPLLPP FSFGAEGDRP
510 520 530 540 550
TYTLYSCGGE GVIYQHNPWK LTDEASNINK LIRDTNDIKH KLPAHTELSW
560 570 580 590 600
RPDGQYLAIG NEDGTIEVFH TQRLQLICTI QQHHKLVNAV RWHHGHSQDP
610 620 630 640 650
DLNFLLASGS NNATVYVHNL KGPLENPTDS PVTITEPFRT LPGHTAKITS
660 670 680 690 700
LSWSPHHDAR LVSASYDGTA QVWDVLQEEP LSNYRGHKGR LLSVQWSPVE
710 720 730 740 750
PDQVWTGADD FCLHSWSVSK QEHSRPPKGK KATELEKKRT LQPKPKAKKK
760 770 780 790 800
KKLDTPKEEA GREVQRGEKE SPLTQNGTSD QEEGQGTPEP EALPADVECP
810 820 830 840 850
FQPVVPSPVP AQDKHSPISF AKTVPVRKDL AKERADLQIR KKKSRSLLPI
860 870 880 890 900
STSKDHRSKE EQHRDCVKLA TVVCAKDLEE KSHFHSEDTM HLGLYSDRAA
910 920 930 940 950
LYHLMEEEGK AHLENGHPEL QHQIMLWKGD LKGTLQLAAE RGELTDQLVA
960 970 980 990 1000
LSPVAGYKVW LWTVEAFVKQ LCFHEQYVKA ASHLLSINKV YEAVELLKGN
1010 1020 1030 1040 1050
HLYREAIAVA KARLLPDDSV LRELYTSWAA VLEQDGHYSM AAKCYLGSSS
1060 1070 1080 1090 1100
PYDAAKVLAK KGDLLSLSAA AELALVAGEK DLAASFAIRC AQELFTAKNF
1110 1120 1130 1140 1150
LAAQEALRQH NSLLGQRLLF CTSELLYMHL KEKMPIDWKT QSNPCFHEQT
1160 1170 1180 1190 1200
GSSNGEPFMT KLTSLWQSLC EVNSPEQYKD ALQQLSASEI PQTTVNTGPK
1210 1220 1230 1240 1250
QLLLHLSHEV TILSLNCQLK NWKEAVPSLL HILFRCQQAG HFTLMQGIAS
1260 1270 1280 1290 1300
LLLPNGCEEL RALLSPENKE NLTACDSVQA FLAYIKMYEL WWGQQEMPPN
1310 1320 1330 1340 1350
SKDPAAAVNM DSPNGASAAV QEPDMKPGDL CGFQVLLSDL HAPFQSAQRE
1360 1370 1380 1390 1400
IAEVQRALRE MIQQHQRIRQ NQDSSLELEQ EPELNTSSSQ DKSLDSQFSP
1410 1420 1430 1440 1450
TISQYRSAGP SPVSLTELMK KLSVANHRLA EFPEYLKALP FPDVLESCLV
1460 1470 1480
LLHLPSYQIS PEIRSQALAL LHSHSHGSAD HQIAAKKFL
Length:1,489
Mass (Da):165,824
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51452136EF7CBA4C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01011390 Genomic DNA No translation available.
AAMC01011391 Genomic DNA No translation available.
AAMC01011392 Genomic DNA No translation available.
AAMC01011393 Genomic DNA No translation available.
AAMC01011394 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000042042; ENSXETP00000042042; ENSXETG00000019404

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011390 Genomic DNA No translation available.
AAMC01011391 Genomic DNA No translation available.
AAMC01011392 Genomic DNA No translation available.
AAMC01011393 Genomic DNA No translation available.
AAMC01011394 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042042

Proteomic databases

PaxDbiF7CD46

Genome annotation databases

EnsembliENSXETT00000042042; ENSXETP00000042042; ENSXETG00000019404

Organism-specific databases

XenbaseiXB-GENE-981572 gemin5

Phylogenomic databases

eggNOGiENOG410IJDN Eukaryota
ENOG410XTH3 LUCA
GeneTreeiENSGT00620000088064
InParanoidiF7CD46
OMAiKLGDHQS
TreeFamiTF328886

Enzyme and pathway databases

ReactomeiR-XTR-191859 snRNP Assembly

Gene expression databases

BgeeiENSXETG00000019404 Expressed in 11 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 12 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CD46_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CD46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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