UniProtKB - F7C8K5 (F7C8K5_HORSE)
Protein
Submitted name:
Transient receptor potential cation channel subfamily C member 6
Gene
TRPC6
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- inositol 1,4,5 trisphosphate binding Source: GO_Central
- protein homodimerization activity Source: Ensembl
- store-operated calcium channel activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- manganese ion transport Source: GO_Central
- positive regulation of calcium ion transport Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of ion transmembrane transporter activity Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: GO_Central
- single fertilization Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Transient receptor potential cation channel subfamily C member 6Imported |
Gene namesi | Name:TRPC6Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:24554, TRPC6 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cation channel complex Source: GO_Central
- cytoplasm Source: Ensembl
- slit diaphragm Source: Ensembl
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000023421, Expressed in synovial membrane of synovial joint and 18 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203539 |
HOGENOMi | CLU_005716_4_2_1 |
InParanoidi | F7C8K5 |
OrthoDBi | 1018075at2759 |
TreeFami | TF313147 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005462, TRPC6_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit PTHR10117:SF7, PTHR10117:SF7, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP PR01647, TRPCHANNEL6 |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 2 hits PS50088, ANK_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F7C8K5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQSPAFGPR RGGSPRVAAG AGARRNESQD YLLMDSELGD DGCPQPPLPP
60 70 80 90 100
YGYYPSFRGT DNRLAHRRQT ILREKGRRLA NRGPAYMFND HSTSLSIEEE
110 120 130 140 150
RFLDAAEYGN IPVVRKMLEE CLSLNVNCVD YMGQNALQLA VANEHLEITE
160 170 180 190 200
LLLKKENLSR VGDALLLAIS KGYVRIVEAI LSHPAFAEGK RLATSPSQSE
210 220 230 240 250
LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR KGARIERPHD
260 270 280 290 300
YFCKCSECNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL
310 320 330 340 350
SNELAVLANI EKEFKNDYKK LSVQCKDFVV GLLDLCRNTE EVEAILNGDV
360 370 380 390 400
EIHHSGGDRG RPNLSRLKLA IKYEVKKFVA HPNCQQQLLS IWYENLSGLR
410 420 430 440 450
QQTMAVKFLV VLAVAIGLPF LALVYWLAPC SKMGKIMRGP FMKFVAHAAS
460 470 480 490 500
FTIFLGLLVM NAADRFEGTK LLPNETSTDN AKQLFRMKTS CFSWMEMLII
510 520 530 540 550
SWVIGMIWAE CKEIWTQGPK EYLFELWNML DFGMLAIFAA SFIARFMAFW
560 570 580 590 600
HASKAQSIID ANDTLKDLTK VTLGDNVKYY NLARIKWDPS DPQIISEGLY
610 620 630 640 650
AIAVVLSFSR IAYILPANES FGPLQISLGR TVKDIFKFMV IFIMVFVAFM
660 670 680 690 700
IGMFNLYSYY IGAKQNEAFT TVEESFKTLF WAIFGLSEVK SVVINYNHKF
710 720 730 740 750
IENIGYVLYG VYNVTMVIVL LNMLIAMINS SFQEIEDDAD VEWKFARAKL
760 770 780 790 800
WFSYFEEGRT LPVPFNLVPS PKSLFYLLLR LKKWISELFQ SHKKGFQEDP
810 820 830 840 850
EMNKRNEEKK FGILGSHENL SKLSLDKKQL GHSKQSSIRS SEDFQLNSFN
860 870 880 890 900
NPPRQYQKIM KRLIKRYVLK AQTDKESDEV NEGELKEIKQ DISSLRYELL
910 920 930
EEKTQNSEDL AELIRKLGEK LSMEPNQEES NR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HXJ9 | A0A3Q2HXJ9_HORSE | Transient receptor potential cation... | TRPC6 | 877 | Annotation score: | ||
A0A3Q2L4L0 | A0A3Q2L4L0_HORSE | Transient receptor potential cation... | TRPC6 | 854 | Annotation score: | ||
A0A3Q2HGY6 | A0A3Q2HGY6_HORSE | Transient receptor potential cation... | TRPC6 | 815 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025366; ENSECAP00000021101; ENSECAG00000023421 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7C8K5 |
Genome annotation databases
Ensembli | ENSECAT00000025366; ENSECAP00000021101; ENSECAG00000023421 |
Organism-specific databases
VGNCi | VGNC:24554, TRPC6 |
Phylogenomic databases
GeneTreei | ENSGT00990000203539 |
HOGENOMi | CLU_005716_4_2_1 |
InParanoidi | F7C8K5 |
OrthoDBi | 1018075at2759 |
TreeFami | TF313147 |
Gene expression databases
Bgeei | ENSECAG00000023421, Expressed in synovial membrane of synovial joint and 18 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005462, TRPC6_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit PTHR10117:SF7, PTHR10117:SF7, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP PR01647, TRPCHANNEL6 |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 2 hits PS50088, ANK_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7C8K5_HORSE | |
Accessioni | F7C8K5Primary (citable) accession number: F7C8K5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |