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Entry version 42 (12 Aug 2020)
Sequence version 2 (10 Apr 2019)
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Protein

SpoU_methylase domain-containing protein

Gene

TARBP1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SpoU_methylase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TARBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7C877

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000023673, Expressed in cerebellum and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F7C877, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1458 – 1599SpoU_methylaseInterPro annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni847 – 868DisorderedSequence analysisAdd BLAST22

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002618_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7C877

TreeFam database of animal gene trees

More...
TreeFami
TF314976

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR016024, ARM-type_fold
IPR025806, Prob_MeTrfase_TARBP1
IPR001537, SpoU_MeTrfase
IPR029026, tRNA_m1G_MTases_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00588, SpoU_methylase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF75217, SSF75217, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51624, SAM_MT_TRMH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7C877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWVLAEALL SQSRDPRVLL GALCRGEASA ERVETLRFLL QRLEDEAARG
60 70 80 90 100
GDAGALPEAA REVAAGYLVP LLRGLRGRPA GGSEPGPPGR QRRRVLRAAG
110 120 130 140 150
AALRSCARLA GGPQLAAALA EEALRDLLAV WPASGLEGAV EVLAAVGPCL
160 170 180 190 200
RPCEDGPLLQ RVAEAALAVA LGGHGDGDEA GPAEDAAALV AGRLLPALGQ
210 220 230 240 250
CGGAALRAVW GGLVAPGMPS GPGRVGPKLL VLSALAEKLL PEPGADGGPG
260 270 280 290 300
AREAGPDARR CGRFWRTVQA GLGRAEDALT RKRARYLLQR AVEVSAELGA
310 320 330 340 350
DCACACAPQE GNGPSLFWWS DKKKDELLKF WENYILIMET LEGNQIHVIK
360 370 380 390 400
PVLPKLNSLF ECAVSEGNGC WLFHPSWHMC IYKRMFESEN KILTKEGVIH
410 420 430 440 450
FLELYETKVL PFSPELSEFI IGPLMDALSE SSLYSRSPGQ LIGSGSPLGL
460 470 480 490 500
KLQKFLVTFI SLLPEEIKSS FLLRFIQKMT SRHWCAIPIL FLSKALASVP
510 520 530 540 550
RCKALGIEGL LALRDVLQCT MITHQILLRG AAQCYLLQTA MNLVDVEKVS
560 570 580 590 600
LSDISTFLMS LRQEESLGRG TSLWTELCDW LRVNEGCFRR LSTCSSTGLS
610 620 630 640 650
ETASLNAYVR NLVQEYVKSP AWETGENCFM PDWFEARLVA MMVLLAVDVE
660 670 680 690 700
GMKIQYSEKR RTQNVLRIFL DPLLDALMKF GTNAYMPLLK TDRCLQLLLK
710 720 730 740 750
LLHTCLLKGS STQDDEVCTL LQNFVMSTTE SISEFILRRL TMNELSSVSD
760 770 780 790 800
LDRCHLYLMV LTELINLHVK VGWKRGNPIW RVISPLKNAS IRHLQEMDSG
810 820 830 840 850
QEPTLGRQVQ RVVSMAALAM VCEAIDQKPE LQLDSLDAGP TERFLSSLQP
860 870 880 890 900
NQTLQKPHTE EPSSFFEESS SSQGWGKIVA QYIHDQWVCL SFLLKKYHSL
910 920 930 940 950
IPPSEGEVLE PVLPAVQMPI RTLQSALEAL TVLPSDQVLP VFQCMKILVP
960 970 980 990 1000
KLLTSSESLC IESFDMAWKI ISSLSNTQLI FWSNLKAFVQ FVFDTKVLTI
1010 1020 1030 1040 1050
AAKIKGQAYF KIKEIMYKII EMSALKTGVF NTLISYCCQS WIVSPSNVSQ
1060 1070 1080 1090 1100
ESLSSAKNYS ELVLEACIFG TVFRRDQRLI QDVQTFVENL GRDCAANVVI
1110 1120 1130 1140 1150
ENTKREDHYV RICAVKFLCL LDGSNMSHKL FMEDLAIKLL DKDEVVSKSR
1160 1170 1180 1190 1200
TRYYVNSQQH RVKNRIWQTL LVLFPRFDQN FLNRIIDKIF QAGFINNQAS
1210 1220 1230 1240 1250
IKYFIEWIII LILHKFPQFL PKFWDCFSYG EENLKTSICT FLSVLSHLDI
1260 1270 1280 1290 1300
ITQNIPEKKL ILKQALIIVL QWCFNHNFSI RLYALVALKK IWNMCKTMHV
1310 1320 1330 1340 1350
EEFDALTSVI ESSLNQVENM HGAGNAKKNW QRIQEHFFFA TFHPLKDYCL
1360 1370 1380 1390 1400
ETIFYILPRL SGLVEDEWIA IGKFTSFTDI PLDAGFQWYL SSTQLCDLEP
1410 1420 1430 1440 1450
GDWAQQDRGF NSGEADDQSE WTDVQKKIIP WKNNVPDLDL ELAFQDRAAK
1460 1470 1480 1490 1500
LGKSISRLIV VASLIDKPTN LGGLCRTCEV FGALVLVVGS LHCVKDKQFQ
1510 1520 1530 1540 1550
HLSVSAEQWL PLVEVKPPQL IDYLQQKKAE GYTIIGVEQT AKSLDLTQYC
1560 1570 1580 1590 1600
FPEKSLLLLG NEREGIPANL IQQLDVCVEI PQQGIIRSLN VHVSGALLIW
1610
EYTRQQLLKH GDTES
Length:1,615
Mass (Da):180,596
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08A15C2E7019F4BA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2H2T7A0A3Q2H2T7_HORSE
SpoU_methylase domain-containing pr...
TARBP1
1,586Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HA53A0A3Q2HA53_HORSE
SpoU_methylase domain-containing pr...
TARBP1
1,524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L8Q0A0A3Q2L8Q0_HORSE
SpoU_methylase domain-containing pr...
TARBP1
1,591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000025393; ENSECAP00000021121; ENSECAG00000023673

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF7C877

Genome annotation databases

EnsembliENSECAT00000025393; ENSECAP00000021121; ENSECAG00000023673

Phylogenomic databases

GeneTreeiENSGT00390000003939
HOGENOMiCLU_002618_1_0_1
InParanoidiF7C877
TreeFamiTF314976

Gene expression databases

BgeeiENSECAG00000023673, Expressed in cerebellum and 22 other tissues
ExpressionAtlasiF7C877, baseline

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR016024, ARM-type_fold
IPR025806, Prob_MeTrfase_TARBP1
IPR001537, SpoU_MeTrfase
IPR029026, tRNA_m1G_MTases_N
PfamiView protein in Pfam
PF00588, SpoU_methylase, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF75217, SSF75217, 1 hit
PROSITEiView protein in PROSITE
PS51624, SAM_MT_TRMH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7C877_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7C877
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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