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Entry version 66 (17 Jun 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Huntingtin

Gene

HTT

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HuntingtinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000003615 Expressed in brain and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000004422

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni196 – 215DisorderedSequence analysisAdd BLAST20
Regioni227 – 335DisorderedSequence analysisAdd BLAST109
Regioni354 – 375DisorderedSequence analysisAdd BLAST22
Regioni923 – 977DisorderedSequence analysisAdd BLAST55
Regioni2391 – 2419DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 270PolarSequence analysisAdd BLAST44
Compositional biasi288 – 335PolarSequence analysisAdd BLAST48
Compositional biasi962 – 977PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZV Eukaryota
ENOG410XSEC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015863

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000428_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7C6C4

Database of Orthologous Groups

More...
OrthoDBi
33894at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323608

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10170 PTHR10170, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12372 DUF3652, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00375 HUNTINGTIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7C6C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VLLKAFIANL KSSSPTIRRT AAGSAVSICQ HSRRTQYFYT WLLNVLLGLL
60 70 80 90 100
VPVEEEHSTL FILGVLLTLR YLIPLLQQQV KDMSLKGSFG VTRKETEISP
110 120 130 140 150
STDQLIQVYE LTLHYTQHQD HNVVTGALEL LQQLFKTPPV ELLQALTTAG
160 170 180 190 200
GFGQVNVTKE EFSRSRSGSI VELIAGGGSS CSPVLSRKQK GKVLLGEEEG
210 220 230 240 250
LEDDPESRSE VSSATFAASM KSEITGELAS SSGVSTPVST SSAADSTGHD
260 270 280 290 300
IITEQPRSQH TLQSDPVDLT GCDLTSAATD GDEEDMLSRS SSQISAVPSD
310 320 330 340 350
PAVDMNDGTQ ASSPISDSSQ TTTEGPDSAV TPSDSSEIVL DGAESQYSGM
360 370 380 390 400
QIGQLQDEDD ETSNVLPDET PDSFRDSTIA LQQPHLLKST GHSRQPSDSS
410 420 430 440 450
VDRFLSKDEA VELGDHESKP SRVKGDIGHF TDTDLAPLVH CVRLLSASFL
460 470 480 490 500
LTGEKGALVP DRDVRVSVKA LAVSCVGAAV ALHPESFFSK LYKTPLETME
510 520 530 540 550
HPEDQYVSDV LNYIDHGDPQ IRGATAILCG TIIYSILNKS RFSVENWLTA
560 570 580 590 600
VRNSTGNTFS LVDCIPLLQK SLKDESSVTC KLACTAVRHC VMSLCSSCFS
610 620 630 640 650
ELGLQLIIDV LTLRNSSYWL VRTELLDTLA EIDFRLISFL EAKADHLHKG
660 670 680 690 700
SHHYTGLLKL QDRVLNNVVI YLLGDEDPRV RHVAASSLIR LVPKLFYNCD
710 720 730 740 750
QGQTDPVVAV ARDQSNVYLK LLMHETQPPS HFSVSTITRT YRGYNLLPSI
760 770 780 790 800
TDVTMENNLS RVIAAVSHAL TTSTTRALTF GCCEALCLLS TAFPVCIWSL
810 820 830 840 850
GWHCGVPLLS PSDESRKSCT VGMATTVLTL LSSAWFPLDL SAHQDAIILA
860 870 880 890 900
GNLLAASAPK SLKNPWTTED EANPGAMKQE EPWPALGDRV LVQMVEQLFS
910 920 930 940 950
HLLKAINICA HVLDDVTPGP AIKAALPSLT NPPSLSPIRR KGKEKEPGEQ
960 970 980 990 1000
ASVPLSPKKG NEASPASRSS DPSGPAITSK SSTLGSFYHL PSYLKLYDVL
1010 1020 1030 1040 1050
KATHANYKVT LDLQNSSEKF GGFLRAALDV LSQILELATL QDIGKCVEEI
1060 1070 1080 1090 1100
LGYLKSCFNR EPTMATVCVQ QLLKTLFGTN LASQYDGLSS KPSKSQGKAQ
1110 1120 1130 1140 1150
RLGSSSLRPG LYHYCFMAPY THFTQALADA SLRNMVQADQ EHDTSGWFDV
1160 1170 1180 1190 1200
LQKVSTQLKT NLTSVTKHRA DKNAIHNHIR LFEPLVIKAL KQYTTTTSVQ
1210 1220 1230 1240 1250
LQRQVLDLLA QLVQLRVNYC LLDSDQVFIG FVLKQFEYIE VGQFRESEAI
1260 1270 1280 1290 1300
IPNIFFFLVL LSYERYHSKQ IIGIPKIIQL CDGIMASGRK AVTHAIPALQ
1310 1320 1330 1340 1350
PIVHDLFVLR GTNKADAGKE LETQKEVAVS MLLRLIQYHQ VLEMFILVLQ
1360 1370 1380 1390 1400
QCHKENEDKW KRLSRQIADI ILPMLAKQQM HIDSHEALGV LNTLFEILAP
1410 1420 1430 1440 1450
SSLRPVDMLL RSMFVTPNTM ASVSTVQLWI SGILAILRVL ISQSTEDIVL
1460 1470 1480 1490 1500
SRIQELSFSP HLISCQIIKK LRDGGSSLPT PEDQSEVKQA AKCLPEETFS
1510 1520 1530 1540 1550
RFLLQLVGIL LEDIVMKQLK VEMSEQQHTF YCQELGTLLM CLIHIFKSGM
1560 1570 1580 1590 1600
FRRITAAATR LFTGDGSDGS FYTLESLSEL VRSMIPTHPS LVLLWCQILL
1610 1620 1630 1640 1650
LVNYTNYNWW SEVHQTPKRH SLSSTKLLSP QMSSDGEDSH LASTLGVCNR
1660 1670 1680 1690 1700
EIVRRGALIL FCDYVCQNLY DSEHLTWLIV NHIQDLISLS HEPPVQDFIS
1710 1720 1730 1740 1750
AVHRNSAASG LFIQAIQSRC ENLSSPTTLK KTLQCLEGIH LSQSGAVLML
1760 1770 1780 1790 1800
YVDKLLCTPF RVLARMVDTL ACRRVEMLLA ANLQNSMSQL PVEELNRIQE
1810 1820 1830 1840 1850
YLQKSGLAQR HQRLYSLLDR FRHTVAPETA SPSPVVTSHP LDGENHLSLE
1860 1870 1880 1890 1900
MINPDQDWYL SLVKFQCCTK SDSALLEGAE LVNRIPPGEL TPFMLSKEFN
1910 1920 1930 1940 1950
LCLLAPCLSL GVREISSGQS SSLFETARSV TLDRVASLVQ QLPSSHQVFQ
1960 1970 1980 1990 2000
PLLPIETSAY WNQLSDLFGN AVIYQSVTTL ACALAQYLVL LSKLPSHLQL
2010 2020 2030 2040 2050
PPEKESDILK FVVAALEALS WHLIHEQMPL SMDLQAVLDC CCLTLQLPAL
2060 2070 2080 2090 2100
WNMLSSIEYV THVCSLIHCV RFILEAIAIQ PGDQLLSPER RKNTPRGISE
2110 2120 2130 2140 2150
DEIDSNMQVP RYITAACEMI AEMVAALQTV LSLGHKRNNG IPAFLTPVLK
2160 2170 2180 2190 2200
NIIISLARLP LVNSYTRVPP LVWKLGWSPK PGGEFGTTLP EIPVEFLQEK
2210 2220 2230 2240 2250
EIFKEFIYRI NTLGWTSRTQ FEETWATLLG VLVTQPIVMD QEESQQEEDT
2260 2270 2280 2290 2300
ERTQINVLAV QAITSLVLSA MTLPVAGNPA VSCLEQQPRN KALKALDTRF
2310 2320 2330 2340 2350
GRKLSVIRGI VEQEIQAMVS KRDNIPTHHL YQAWDPVPSL SPAMSGALIS
2360 2370 2380 2390 2400
HEKLLLQINT EREMGNMSYN LGQVSIHSMW LGNNITPLRE EEWDEDEEDD
2410 2420 2430 2440 2450
GDLPAPSSPP TSPINSRKHR AGVDIHSCSQ FLLELYSQWI LPSSSAKRTP
2460 2470 2480 2490 2500
VILISEVVRS LLAVSDLFTE RNQFEMMYLT LTELRRVHPS EDEILIQYLV
2510 2520 2530 2540 2550
PATCKAAAVL GMDKAVAEPV SRLLETTLRS THLPSKIGAL HGILYVLECD
2560 2570 2580 2590 2600
LLDETAKQLI PIISDYLLSN LRGIAHCVNL HSQQHVLVTC AAAFYLMENY
2610 2620 2630 2640 2650
PLDVGPEFSA AVIQMCGVML SASEESTPAI IYHCVLRGLE RLLLSEQLSR
2660 2670 2680 2690 2700
LDGESLVKLS VDRVNVHSPH RAMAALGLML TCMYTGKEKI SPGRTSDPNP
2710 2720 2730 2740 2750
TAPDSESVIV AMERVSVLFD RIRKGFPCEA RVVARILPQF LDDFFPPQDV
2760 2770 2780 2790 2800
MNKVIGEFLS NQQPYPQFMA TVVYKVFQTL HTTGQSSMVR DWVMLSLSNF
2810 2820 2830 2840 2850
TQRTPVAMAM WSLSCFFVSA STSQWVSAIL PHIISRMGKS EQVDINLFCL
2860 2870 2880 2890
VAIDFYRHQI DEELDRRAFQ SVFEVVASPG NPYHRLLTCL QNVHKIAAC
Length:2,899
Mass (Da):321,295
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D7D373C5248F8EE
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000004517; ENSMODP00000004422; ENSMODG00000003615

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000004422

Genome annotation databases

EnsembliENSMODT00000004517; ENSMODP00000004422; ENSMODG00000003615

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA
GeneTreeiENSGT00390000015863
HOGENOMiCLU_000428_0_0_1
InParanoidiF7C6C4
OrthoDBi33894at2759
TreeFamiTF323608

Gene expression databases

BgeeiENSMODG00000003615 Expressed in brain and 7 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
PRINTSiPR00375 HUNTINGTIN
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7C6C4_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7C6C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: June 17, 2020
This is version 66 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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