UniProtKB - F7C3H1 (F7C3H1_HORSE)
Protein
Submitted name:
LDL receptor related protein 4
Gene
LRP4
Organism
Equus caballus (Horse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- protein homodimerization activity Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
GO - Biological processi
- amyloid-beta clearance by cellular catabolic process Source: Ensembl
- dorsal/ventral pattern formation Source: Ensembl
- embryonic digit morphogenesis Source: Ensembl
- endocytosis Source: UniProtKB-KW
- hair follicle development Source: Ensembl
- kidney development Source: Ensembl
- negative regulation of axonogenesis Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of ossification Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of presynaptic membrane organization Source: Ensembl
- positive regulation of skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
- postsynaptic membrane assembly Source: Ensembl
- presynaptic membrane assembly Source: Ensembl
- proximal/distal pattern formation Source: Ensembl
- skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
- synaptic growth at neuromuscular junction Source: Ensembl
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | ReceptorARBA annotation |
Biological process | EndocytosisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: LDL receptor related protein 4Imported |
Gene namesi | Name:LRP4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19763, LRP4 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- neuromuscular junction Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1724 – 1747 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5018567474 | 21 – 1905 | Sequence analysisAdd BLAST | 1885 |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PaxDbi | F7C3H1 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023663, Expressed in spinal cord and 20 other tissues |
Interactioni
GO - Molecular functioni
- protein homodimerization activity Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 418 – 433 | EGF-likeInterPro annotationAdd BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1659 – 1695 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1851 – 1905 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1666 – 1692 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1851 – 1881 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1888 – 1905 | PolyampholyteSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the LDLR family.ARBA annotation
Keywords - Domaini
EGF-like domainARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158287 |
HOGENOMi | CLU_000085_4_0_1 |
InParanoidi | F7C3H1 |
TreeFami | TF315253 |
Family and domain databases
CDDi | cd00112, LDLa, 7 hits |
Gene3Di | 2.120.10.30, 4 hits 4.10.400.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF00057, Ldl_recept_a, 8 hits PF00058, Ldl_recept_b, 16 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 8 hits SM00135, LY, 20 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 8 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 4 hits PS50068, LDLRA_2, 8 hits PS51120, LDLRB, 20 hits |
i Sequence
Sequence statusi: Complete.
F7C3H1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRPWGALLL GALLCAHGLA SSPQCACGRN HFTCAVSALG ECTCIPAQWQ
60 70 80 90 100
CDGDNDCGDH SDEDGCMLPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS
110 120 130 140 150
DEQDCPPREC EEDEFPCQNG YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD
160 170 180 190 200
KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE NCPSAVPAPP CNLEEFQCAY
210 220 230 240 250
GRCILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS GLCINAGWRC
260 270 280 290 300
DGDADCDDQS DERNCTTSMC TAEQFRCRSG RCVRLSWRCD GEDDCADNSD
310 320 330 340 350
EENCENTGSP QCASDQFLCW NGRCIGQRKL CNGVNDCGDN SDESPQQNCR
360 370 380 390 400
PRTGEESCNV NNGGCAQKCQ MVRGTVQCTC HTGYRLTEDG HMCQDVNECA
410 420 430 440 450
EEGYCSQGCT NSEGAFQCWC EAGYELRPDR RSCKALGPEP VLLFANRIDI
460 470 480 490 500
RQVLPHRSEY TLLLNNLENA IALDFHHRRE LVFWSDVTLD RILRANLNGS
510 520 530 540 550
NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL DGAHRKVLLW
560 570 580 590 600
QNLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP
610 620 630 640 650
NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE
660 670 680 690 700
DSLYWTDWHT KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN
710 720 730 740 750
RCGDNNGGCT HLCLPSGHNY TCACPTGFRK ISSHACAQSL DKFLLFARRM
760 770 780 790 800
DIRRISFDTE DLSDDVIPLA DVRSAVALDW DSRDDHVYWT DVSTDTISRA
810 820 830 840 850
KWDGTGQEVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI EVANTDGSMR
860 870 880 890 900
TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASSRQVIISS
910 920 930 940 950
NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG
960 970 980 990 1000
LTLYGERIYW TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRRRP
1010 1020 1030 1040 1050
PVSTPCAVEN GGCSHLCLRS PNPSGFSCTC PTGINLMPDG KTCSPGMNSF
1060 1070 1080 1090 1100
LIFARRIDVR LVSLDIPYFA DVVVPINITM KNTIAIGVDP QEGKVYWSDS
1110 1120 1130 1140 1150
TLHRISRANL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW TDTGTNRIEV
1160 1170 1180 1190 1200
GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS
1210 1220 1230 1240 1250
ERTVLISNNL GWPNGLTVDK AGSQLLWADA HTERIEAADL NGANRHTLVS
1260 1270 1280 1290 1300
PVQHPYGLTL LDSYIYWTDW QTRSIHRADK GTGSNVILVR SNLPGLMDIQ
1310 1320 1330 1340 1350
AVDRAQPLGF NKCGSRNGGC SHLCLPRPSG FSCACPTGIQ LKGDGKTCDP
1360 1370 1380 1390 1400
SPETYLLFSS RGSIRRISLD TSDHTDVHVP VPELNNVISL DYDSVDGKVY
1410 1420 1430 1440 1450
YTDVFLDVIR RADLNGSNME TVIGRGLKTT DGLAVDWVAR NLYWTDTGRN
1460 1470 1480 1490 1500
TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN
1510 1520 1530 1540 1550
LDGSERKVLI NTDLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLSGKLRQ
1560 1570 1580 1590 1600
VLVSHVSHPF ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL
1610 1620 1630 1640 1650
MDIIVVSPQR QTGTNACGVN NGGCTHLCFA RALDFVCACP DEPDGQPCSL
1660 1670 1680 1690 1700
VPGLVPPAPR ATSMSERSPV LPNTLPTTLR SPTTQTRTSL EEVGGRCSEK
1710 1720 1730 1740 1750
DTQLGLCAHS NEAVPAAPGE GLHVSYVIGG LLSILLILVV IAALMLYRHK
1760 1770 1780 1790 1800
KSKLTDPGLG NLTYSNPSYR TSTQEVKIEA IPTPAMYNQL CYKKEGGPDH
1810 1820 1830 1840 1850
NYTKEKIKIV EGICLLSGDD AEWDDLKQLR SSRGGLLRDH VCMKTDTVSI
1860 1870 1880 1890 1900
QASSGSLDDT ETEQLLQEEQ SECSSVHTAA TPERRGSLPD TGWKHERKLS
SESQV
Genome annotation databases
Ensembli | ENSECAT00000025418; ENSECAP00000021146; ENSECAG00000023663 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7C3H1 |
Genome annotation databases
Ensembli | ENSECAT00000025418; ENSECAP00000021146; ENSECAG00000023663 |
Organism-specific databases
VGNCi | VGNC:19763, LRP4 |
Phylogenomic databases
GeneTreei | ENSGT00940000158287 |
HOGENOMi | CLU_000085_4_0_1 |
InParanoidi | F7C3H1 |
TreeFami | TF315253 |
Gene expression databases
Bgeei | ENSECAG00000023663, Expressed in spinal cord and 20 other tissues |
Family and domain databases
CDDi | cd00112, LDLa, 7 hits |
Gene3Di | 2.120.10.30, 4 hits 4.10.400.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF12662, cEGF, 1 hit PF00057, Ldl_recept_a, 8 hits PF00058, Ldl_recept_b, 16 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 8 hits SM00135, LY, 20 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 8 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 4 hits PS50068, LDLRA_2, 8 hits PS51120, LDLRB, 20 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7C3H1_HORSE | |
Accessioni | F7C3H1Primary (citable) accession number: F7C3H1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |