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Protein

Nibrin

Gene

nbn

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycleUniRule annotation, DNA damage, DNA repairUniRule annotation, MeiosisUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-2559586 DNA Damage/Telomere Stress Induced Senescence
R-XTR-5685938 HDR through Single Strand Annealing (SSA)
R-XTR-5685939 HDR through MMEJ (alt-NHEJ)
R-XTR-5685942 HDR through Homologous Recombination (HRR)
R-XTR-5693548 Sensing of DNA Double Strand Breaks
R-XTR-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-XTR-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-XTR-5693571 Nonhomologous End-Joining (NHEJ)
R-XTR-5693579 Homologous DNA Pairing and Strand Exchange
R-XTR-5693607 Processing of DNA double-strand break ends
R-XTR-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-XTR-6804756 Regulation of TP53 Activity through Phosphorylation
R-XTR-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
NibrinUniRule annotation
Gene namesi
Name:nbnImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-943036 nbn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, NucleusUniRule annotation, TelomereUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF7C3F8

Expressioni

Gene expression databases

BgeeiENSXETG00000014611
ExpressionAtlasiF7C3F8 baseline

Interactioni

Subunit structurei

Component of the MRN complex.UniRule annotation

Protein-protein interaction databases

STRINGi8364.ENSXETP00000058954

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 81FHAInterPro annotationAdd BLAST60

Phylogenomic databases

eggNOGiENOG410IK5M Eukaryota
ENOG410Y1R8 LUCA
GeneTreeiENSGT00390000000521
InParanoidiF7C3F8
OMAiYQLSPTK
OrthoDBiEOG091G0BJ4
TreeFamiTF101103

Family and domain databases

CDDicd00027 BRCT, 1 hit
cd00060 FHA, 1 hit
Gene3Di3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR013908 DNA-repair_Nbs1_C
IPR000253 FHA_dom
IPR032429 Nibrin_BRCT2
IPR016592 Nibrin_met
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF08599 Nbs1_C, 1 hit
PF16508 NIBRIN_BRCT_II, 1 hit
PF16770 RTT107_BRCT_5, 1 hit
PIRSFiPIRSF011869 Nibrin_animal, 1 hit
SMARTiView protein in SMART
SM01348 Nbs1_C, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

F7C3F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLVAERAG GDTYYILTGT DYVVGRKNCA ILIPDDQSIS RCHATLSVSY
60 70 80 90 100
PSASLSQTNA VSVLTIKDSS KYGTTVSGER MQPAVPRSLK PSDEVIFGCF
110 120 130 140 150
HSKYRVEYEP LVVCSSCLDN TEKNSLKQNL IHLGGHMLNN WTEKCTHLVM
160 170 180 190 200
TSIKVTIKTI CALICCKPIV KPDYFRELIN AIQQKRPLPE YRSFIPPIDE
210 220 230 240 250
PSLNPESLDL SENVKRKSIF KDKVFLFLNT KQYMKLSPAV LLGGGKAHLL
260 270 280 290 300
ESLTDTSVLE NSTTCVIDVA MTETQLSETQ STQPWISSTL DLLHSQDLTR
310 320 330 340 350
LPKAENLMLV LYFSAWIWES QKCCSASITV AGTSKRTQVL SSTLSQGMTV
360 370 380 390 400
DETVLPAPAL NMTAYVADTE PQDQTDTGMN ISGVREVKET PGSSSSHSRS
410 420 430 440 450
RSCIEKEPKS GSSNDLRQAL FQGDKTETRN KNNHPLLPIK PSARDVGKTS
460 470 480 490 500
QKLQPTKKID SYFQSLAKKR DRDEDEKEVS SAKLARVEPV SSQSTEEQFR
510 520 530 540 550
PITEALDKEE DNFDSDLDME LAMSCDQILN DSMGSNKVIP EDPTMKKRKV
560 570 580 590 600
PDDHVVEESD IDSDEGISAN AEQNDTESNL NKTKKRKLDS KIEGVKELTI
610 620 630 640 650
KPHEIGTKAQ AKTNTPEMEP SVKKEIEVKT EFEVKKEPES PQKETKCVPD
660 670 680 690 700
LAGESDALPS RLLLTEFKSL VVTRPVRNNN TTSNSSNENC QNFKKFKKVA
710 720 730 740 750
YPGAGSFPHI IGGSDLIAHD RKRNAELEQW LRQEVEEQTQ QAKEESLAED
760
LFRYNPKSNK RRR
Length:763
Mass (Da):85,343
Last modified:July 27, 2011 - v1
Checksum:i6DAB45A86FF96698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01033345 Genomic DNA No translation available.
AAMC01033346 Genomic DNA No translation available.
AAMC01033347 Genomic DNA No translation available.
AAMC01033348 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000065944; ENSXETP00000058954; ENSXETG00000014611

Similar proteinsi

Entry informationi

Entry nameiF7C3F8_XENTR
AccessioniPrimary (citable) accession number: F7C3F8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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