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UniProtKB - F7BY14 (F7BY14_HORSE)

Entry version 42 (02 Dec 2020)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
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Protein

Non-specific serine/threonine protein kinase

Gene

WNK1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:52460, WNK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000023501, Expressed in brainstem and 23 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 478Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni93 – 202DisorderedSequence analysisAdd BLAST110
Regioni572 – 691DisorderedSequence analysisAdd BLAST120
Regioni1053 – 1087DisorderedSequence analysisAdd BLAST35
Regioni1127 – 1296DisorderedSequence analysisAdd BLAST170
Regioni1456 – 1475DisorderedSequence analysisAdd BLAST20
Regioni1633 – 1658DisorderedSequence analysisAdd BLAST26
Regioni1917 – 1939DisorderedSequence analysisAdd BLAST23
Regioni2046 – 2104DisorderedSequence analysisAdd BLAST59
Regioni2173 – 2248DisorderedSequence analysisAdd BLAST76
Regioni2291 – 2375DisorderedSequence analysisAdd BLAST85
Regioni2422 – 2447DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2252 – 2272Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolarSequence analysisAdd BLAST15
Compositional biasi23 – 37PolarSequence analysisAdd BLAST15
Compositional biasi48 – 64PolyampholyteSequence analysisAdd BLAST17
Compositional biasi96 – 116Pro-richSequence analysisAdd BLAST21
Compositional biasi138 – 152Pro-richSequence analysisAdd BLAST15
Compositional biasi572 – 588PolyampholyteSequence analysisAdd BLAST17
Compositional biasi589 – 629PolarSequence analysisAdd BLAST41
Compositional biasi636 – 691PolarSequence analysisAdd BLAST56
Compositional biasi1054 – 1076PolarSequence analysisAdd BLAST23
Compositional biasi1127 – 1221PolarSequence analysisAdd BLAST95
Compositional biasi1235 – 1269PolarSequence analysisAdd BLAST35
Compositional biasi1273 – 1293BasicSequence analysisAdd BLAST21
Compositional biasi1917 – 1937PolarSequence analysisAdd BLAST21
Compositional biasi2050 – 2064PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2065 – 2097PolarSequence analysisAdd BLAST33
Compositional biasi2209 – 2241PolarSequence analysisAdd BLAST33
Compositional biasi2312 – 2343PolarSequence analysisAdd BLAST32
Compositional biasi2350 – 2375PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155474

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000550_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F7BY14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGAAEKQGS TPSALFLSPP APAPKNGSSS DSSVGEKLGS VGTDAGTGRT 
        60         70         80         90        100
EEYRRRRHTM DKDSRGAAAT TTTTEHRFFR RSVICDSNAT ALELPGLPLP 
       110        120        130        140        150
LPPPSVAAPV PQSAPPEPHR EETSTAAAAA PGAQEPPAAA GPGEPPAAAP 
       160        170        180        190        200
VAAPAPSGTS RDRPGAQPSH EGSKEEPPPA RSGSGGASAK EPQEERSQQQ 
       210        220        230        240        250
DDIEELETKA VGMSNDGRFL KFDIEIGRGS FKTVYKGLDT ETTVEVAWCE 
       260        270        280        290        300
LQDRKLTKSE RQRFKEEAEM LKGLQHPNIV RFYDSWESTV KGKKCIVLVT 
       310        320        330        340        350
ELMTSGTLKT YLKRFKVMKI KVLRSWCRQI LKGLQFLHTR TPPIIHRDLK 
       360        370        380        390        400
CDNIFITGPT GSVKIGDLGL ATLKRASFAK SVIGTPEFMA PEMYEEKYDE 
       410        420        430        440        450
SVDVYAFGMC MLEMATSEYP YSECQNAAQI YRRVTSGVKP ASFDKVAIPE 
       460        470        480        490        500
VKEIIEGCIR QNKDERYSIK DLLNHAFFQE ETGVRVELAE EDDGEKIAIK 
       510        520        530        540        550
LWLRIEDIKK LKGKYKDNEA IEFSFDLERD VPEDVAQEMV ESGYVCEGDH 
       560        570        580        590        600
KTMAKAIKDR VSLIKRKREQ RQLVREEQEK RKQEESSLKQ QVEQQSSASQ 
       610        620        630        640        650
AGIKQLPSAS TSVPAASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL 
       660        670        680        690        700
SDGTIDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTL PGHTASVVQA 
       710        720        730        740        750
QSQPHGVYPP SSMVRPSNDY RMLHPQSMAH PCGGTPTYPE SQIFFPTIHE 
       760        770        780        790        800
RPVSFSPPPT CPPKVAISQR RKSTSFLEAQ THHFQPLLRT VGQNLLPPGG 
       810        820        830        840        850
SSTNWTPEAI VMLGTTANRI TGEPCEIQVH PMFEPTQVYS DYRPGLVLSE 
       860        870        880        890        900
EAHYFIPQEA VYLAGAHYQT QVAEQYEGIP YNSPVLSSHM KQIPEQKPVQ 
       910        920        930        940        950
GGPTSSSVFE FPSGQAFLVG HLQNLRLDSG LSPGSPLSSI SAPISTDATR 
       960        970        980        990       1000
LKFHPIFVPH SAPAVLTHNN ESRSNCVFEF HVHTPSSSSG EGGVLPQRVY 
      1010       1020       1030       1040       1050
RNLQVAVDLN QEEPPPQSVG LHGGLQPVTE EQHNYHAPEL TVSVVEPIGQ 
      1060       1070       1080       1090       1100
NWPIGSPEYS SDSSQITSSD PSDFQSPPPT GGAAAPFGSD VSLPYIRLPQ 
      1110       1120       1130       1140       1150
TVLQESPLFF CFPQGTTSQQ VLSASVSSGG SALHPQAQGQ SQGQPSSSSL 
      1160       1170       1180       1190       1200
TGIPSSQPIQ HSQQQQGIQQ TAPPQQTVQY SLPQTSTSSE TTTAQPVSQP 
      1210       1220       1230       1240       1250
QAPQVLPQVS AGKQSTQGVA QVAPPEPIPV AQPQPTQPTT LVSSIDSAHS 
      1260       1270       1280       1290       1300
DVASGMSDGN ENVPSSSGRH EGRTTKRHYR KSVRSRSRHE KTSRPKLRIL 
      1310       1320       1330       1340       1350
NVSNKGDRVV ECQLETHNRK MVTFKFDLDG DNPEEIATIM VNNDFILAIE 
      1360       1370       1380       1390       1400
RESFVDQVRE IIEKADEMLS EDVSVEPEGE QGLESLQGKD DYGFSGSQKL 
      1410       1420       1430       1440       1450
EGEFKQPIPS SSMPQQIGIP TSSLTQVVHS AGRRFIVSPV PESRLRESKV 
      1460       1470       1480       1490       1500
FTSETSDTVA ASTSHGTGMN LSHSASSLSL QQAFSELRHT QMTEGPSTAP 
      1510       1520       1530       1540       1550
PNFSHTGPTF PVVPPSMTSI AGVPTTAAAT PSVSVSATSC PLNDISTSVI 
      1560       1570       1580       1590       1600
QSEITVPTEK GIAGVATCTG VITSSGLPVP PASESPVLSS VVSSITIPAV 
      1610       1620       1630       1640       1650
VSISTTSQSV QAPTSGSIVS SIGTLPSVPV STTSASTVGS AAAPGAKPPP 
      1660       1670       1680       1690       1700
VLSQQAAGST TGIATLTSVS TTTPFPSIAS QPAFQLSSST SAPTLAETVV 
      1710       1720       1730       1740       1750
ISAHSLDKTS HSSATGLALS LSASSSSPGA GVSSSISQPS GVHPLVIQSA 
      1760       1770       1780       1790       1800
VASTPVLPQA AGPTSTPLLP QVPSIPPLVQ PVASVPAVQQ TLIHSQPQPA 
      1810       1820       1830       1840       1850
LLPNQPHTHC PEIDADTQPK APGIDDIKTL EEKLRSLFSE HSSSGAQHAS 
      1860       1870       1880       1890       1900
VSLETSLVVE TTVTPGIPTT AVAPSKLMTS TTSTCLPPTS LPLGTTGLSV 
      1910       1920       1930       1940       1950
IPVVTPGQVS TPVSYVSAPV SSTPGVKPGT TPSKPSLTKA PVLPVGTELP 
      1960       1970       1980       1990       2000
AGTLPSDQLP PFPGPSLTQQ PLEDLDAQLR RTLSPETVAV TSAVGPVSVV 
      2010       2020       2030       2040       2050
APTAVTEAAA QPQKDVSQVT EGPVLATTSG TGVFKMGRFQ VSVAMDDAQK 
      2060       2070       2080       2090       2100
EGQSKSEDAK SVHFESSTSE SSVLSSSSPE STLVKPEPNS VTIHGISSDV 
      2110       2120       2130       2140       2150
PDSAHKTPLL AAKSETGQST KVGRFQVTTT ANKVGRFSVS RTEDKIAEAK 
      2160       2170       2180       2190       2200
KEGPMASPPF MDLEQATLPA VIPKKEKPEL SEPSHLNGPS SDLEAAFLSR 
      2210       2220       2230       2240       2250
DVDDGSGSPH SPHQLSSKSL PVQNLSQSLS NSFNSSYMSS DNESDIEDED 
      2260       2270       2280       2290       2300
LKLELRRLRE KHLKEIQDLQ SRQKHEIESL YTKLGKVPPA VIIPPAAPLS 
      2310       2320       2330       2340       2350
GRRRRPTKSK GSKSSRSSSL GNKSPQLSGN LSGQSSASVL HPQQTLHPPG 
      2360       2370       2380       2390       2400
HMPESGQNQL LQPLKPSPSS DNLYSAFTSD GAISVPSLSA PGQGCAKFNC 
      2410       2420       2430       2440       2450
ASEQVTFKPG GRRTRFLRTS STNTVGGTVN SQAAQAQPPA MTSSRKGTFT 
      2460       2470       2480       2490       2500
DDLHKLVDNW ARDAMNLSGR RGSKGHMNYE GPGMARKFSA PGQLCISMTS 
      2510       2520       2530       2540       2550
NLGGSAPISA ASATSLGHFT KSMCPPQQYG FPAPPFGTQW SGTGGPAPQP 
      2560       2570       2580 
LGQFQPVGTA SLQNFNISNL QKSISNPPGS NLRTT
Length:2,585
Mass (Da):274,396
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i784236BEA6A633D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2ID61A0A3Q2ID61_HORSE
Non-specific serine/threonine prote...
WNK1
2,881Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C849F7C849_HORSE
Non-specific serine/threonine prote...
WNK1
2,393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C2Q9F7C2Q9_HORSE
Non-specific serine/threonine prote...
WNK1
2,421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BX86F7BX86_HORSE
Non-specific serine/threonine prote...
WNK1
2,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HGQ1A0A3Q2HGQ1_HORSE
Non-specific serine/threonine prote...
WNK1
2,398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HSN6A0A3Q2HSN6_HORSE
Non-specific serine/threonine prote...
WNK1
2,795Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HYK6A0A3Q2HYK6_HORSE
Non-specific serine/threonine prote...
WNK1
2,349Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IC89A0A3Q2IC89_HORSE
Non-specific serine/threonine prote...
WNK1
2,290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000025447; ENSECAP00000021170; ENSECAG00000023501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000025447; ENSECAP00000021170; ENSECAG00000023501

Organism-specific databases

VGNCiVGNC:52460, WNK1

Phylogenomic databases

GeneTreeiENSGT00940000155474
HOGENOMiCLU_000550_0_0_1

Gene expression databases

BgeeiENSECAG00000023501, Expressed in brainstem and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7BY14_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7BY14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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