UniProtKB - F7BXF0 (F7BXF0_HORSE)
Protein
Mitogen-activated protein kinase
Gene
MAPK4
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase activity Source: GO_Central
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein kinase binding Source: Ensembl
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MAPK4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19959, MAPK4 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023749, Expressed in prefrontal cortex and 19 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein kinase binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 312 | Protein kinaseInterPro annotationAdd BLAST | 293 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 368 – 410 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 495 – 532 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 389 – 410 | PolyampholyteSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000159850 |
HOGENOMi | CLU_000288_181_15_1 |
InParanoidi | F7BXF0 |
TreeFami | TF105098 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR008350, MAPK_ERK3/4 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01771, ERK3ERK4MAPK |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7BXF0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKGDCIAS VYGYDLGGRF VNFQPLGFGV NGLVLSAVDS RACRKVAVKK
60 70 80 90 100
IALSDARSMK HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV
110 120 130 140 150
AYIVQEYMET DLARLLEQGT LTEEHAKLFM YQLLRGLKYI HSANVLHRDL
160 170 180 190 200
KPANIFISTE DLVLKIGDFG LARIVDQHYS HKGHLSEGLV TKWYRSPRLL
210 220 230 240 250
LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL ILETIPVIRE
260 270 280 290 300
EDKDELLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR
310 320 330 340 350
LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDILLM AANQSQLSNW
360 370 380 390 400
DRYPVSLSSD LEWRPDRCQD ASEVQRDPRA GSAPLAEDVQ VDPRKDSQSS
410 420 430 440 450
SERFLEQSHS SMERAFEADY GHSCDYKVGS PSYLDKLLWR DNKPHHYSEP
460 470 480 490 500
KLILDLSHWK QAAGAPPTAA VAADPGARED EPASLFLEIA QWVKSTQGGP
510 520 530 540 550
EHSSPPREGP ERRLSASPPG RPGPIDGGAS PQFDLDVFIS RALKLCTKPE
560 570 580
DLPDNKLGDL NGACISEHPG DLVQTEAFSK ERS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2LJY2 | A0A3Q2LJY2_HORSE | Mitogen-activated protein kinase | MAPK4 | 529 | Annotation score: | ||
A0A5F5PKP0 | A0A5F5PKP0_HORSE | Mitogen-activated protein kinase | MAPK4 | 233 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025463; ENSECAP00000021182; ENSECAG00000023749 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7BXF0 |
Genome annotation databases
Ensembli | ENSECAT00000025463; ENSECAP00000021182; ENSECAG00000023749 |
Organism-specific databases
VGNCi | VGNC:19959, MAPK4 |
Phylogenomic databases
GeneTreei | ENSGT00940000159850 |
HOGENOMi | CLU_000288_181_15_1 |
InParanoidi | F7BXF0 |
TreeFami | TF105098 |
Gene expression databases
Bgeei | ENSECAG00000023749, Expressed in prefrontal cortex and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR008350, MAPK_ERK3/4 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01771, ERK3ERK4MAPK |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7BXF0_HORSE | |
Accessioni | F7BXF0Primary (citable) accession number: F7BXF0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | October 7, 2020 | |
This is version 44 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |