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UniProtKB - F7BX86 (F7BX86_HORSE)

Entry version 43 (02 Dec 2020)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
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Protein

Non-specific serine/threonine protein kinase

Gene

WNK1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:52460, WNK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000023501, Expressed in brainstem and 23 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 478Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni93 – 202DisorderedSequence analysisAdd BLAST110
Regioni572 – 690DisorderedSequence analysisAdd BLAST119
Regioni1128 – 1162DisorderedSequence analysisAdd BLAST35
Regioni1202 – 1371DisorderedSequence analysisAdd BLAST170
Regioni1531 – 1550DisorderedSequence analysisAdd BLAST20
Regioni1708 – 1733DisorderedSequence analysisAdd BLAST26
Regioni1992 – 2014DisorderedSequence analysisAdd BLAST23
Regioni2121 – 2179DisorderedSequence analysisAdd BLAST59
Regioni2248 – 2323DisorderedSequence analysisAdd BLAST76
Regioni2366 – 2450DisorderedSequence analysisAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2327 – 2347Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolarSequence analysisAdd BLAST15
Compositional biasi23 – 37PolarSequence analysisAdd BLAST15
Compositional biasi48 – 64PolyampholyteSequence analysisAdd BLAST17
Compositional biasi96 – 116Pro-richSequence analysisAdd BLAST21
Compositional biasi138 – 152Pro-richSequence analysisAdd BLAST15
Compositional biasi572 – 588PolyampholyteSequence analysisAdd BLAST17
Compositional biasi589 – 629PolarSequence analysisAdd BLAST41
Compositional biasi636 – 690PolarSequence analysisAdd BLAST55
Compositional biasi1129 – 1151PolarSequence analysisAdd BLAST23
Compositional biasi1202 – 1296PolarSequence analysisAdd BLAST95
Compositional biasi1310 – 1344PolarSequence analysisAdd BLAST35
Compositional biasi1348 – 1368BasicSequence analysisAdd BLAST21
Compositional biasi1992 – 2012PolarSequence analysisAdd BLAST21
Compositional biasi2125 – 2139PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2140 – 2172PolarSequence analysisAdd BLAST33
Compositional biasi2284 – 2316PolarSequence analysisAdd BLAST33
Compositional biasi2387 – 2418PolarSequence analysisAdd BLAST32
Compositional biasi2425 – 2450PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155474

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F7BX86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGAAEKQGS TPSALFLSPP APAPKNGSSS DSSVGEKLGS VGTDAGTGRT 
        60         70         80         90        100
EEYRRRRHTM DKDSRGAAAT TTTTEHRFFR RSVICDSNAT ALELPGLPLP 
       110        120        130        140        150
LPPPSVAAPV PQSAPPEPHR EETSTAAAAA PGAQEPPAAA GPGEPPAAAP 
       160        170        180        190        200
VAAPAPSGTS RDRPGAQPSH EGSKEEPPPA RSGSGGASAK EPQEERSQQQ 
       210        220        230        240        250
DDIEELETKA VGMSNDGRFL KFDIEIGRGS FKTVYKGLDT ETTVEVAWCE 
       260        270        280        290        300
LQDRKLTKSE RQRFKEEAEM LKGLQHPNIV RFYDSWESTV KGKKCIVLVT 
       310        320        330        340        350
ELMTSGTLKT YLKRFKVMKI KVLRSWCRQI LKGLQFLHTR TPPIIHRDLK 
       360        370        380        390        400
CDNIFITGPT GSVKIGDLGL ATLKRASFAK SVIGTPEFMA PEMYEEKYDE 
       410        420        430        440        450
SVDVYAFGMC MLEMATSEYP YSECQNAAQI YRRVTSGVKP ASFDKVAIPE 
       460        470        480        490        500
VKEIIEGCIR QNKDERYSIK DLLNHAFFQE ETGVRVELAE EDDGEKIAIK 
       510        520        530        540        550
LWLRIEDIKK LKGKYKDNEA IEFSFDLERD VPEDVAQEMV ESGYVCEGDH 
       560        570        580        590        600
KTMAKAIKDR VSLIKRKREQ RQLVREEQEK RKQEESSLKQ QVEQQSSASQ 
       610        620        630        640        650
AGIKQLPSAS TSVPAASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL 
       660        670        680        690        700
SDGTIDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTL PGHTASVVQA 
       710        720        730        740        750
QSQPHGVYPP SSMPRRGRSM SVCVPHLSAV PFLSRISPSA PSTPPPVLSA 
       760        770        780        790        800
PLCPSLLRTA PEETFAEKLS KALESVLPMH SASQRKHRRS SLPSLFVSTP 
       810        820        830        840        850
QSMAHPCGGT PTYPESQIFF PTIHERPVSF SPPPTCPPKV AISQRRKSTS 
       860        870        880        890        900
FLEAQTHHFQ PLLRTVGQNL LPPGGSSTNW TPEAIVMLGT TANRITGEPC 
       910        920        930        940        950
EIQVHPMFEP TQVYSDYRPG LVLSEEAHYF IPQEAVYLAG AHYQTQVAEQ 
       960        970        980        990       1000
YEGIPYNSPV LSSHMKQIPE QKPVQGGPTS SSVFEFPSGQ AFLVGHLQNL 
      1010       1020       1030       1040       1050
RLDSGLSPGS PLSSISAPIS TDATRLKFHP IFVPHSAPAV LTHNNESRSN 
      1060       1070       1080       1090       1100
CVFEFHVHTP SSSSGEGGVL PQRVYRNLQV AVDLNQEEPP PQSVGLHGGL 
      1110       1120       1130       1140       1150
QPVTEEQHNY HAPELTVSVV EPIGQNWPIG SPEYSSDSSQ ITSSDPSDFQ 
      1160       1170       1180       1190       1200
SPPPTGGAAA PFGSDVSLPY IRLPQTVLQE SPLFFCFPQG TTSQQVLSAS 
      1210       1220       1230       1240       1250
VSSGGSALHP QAQGQSQGQP SSSSLTGIPS SQPIQHSQQQ QGIQQTAPPQ 
      1260       1270       1280       1290       1300
QTVQYSLPQT STSSETTTAQ PVSQPQAPQV LPQVSAGKQS TQGVAQVAPP 
      1310       1320       1330       1340       1350
EPIPVAQPQP TQPTTLVSSI DSAHSDVASG MSDGNENVPS SSGRHEGRTT 
      1360       1370       1380       1390       1400
KRHYRKSVRS RSRHEKTSRP KLRILNVSNK GDRVVECQLE THNRKMVTFK 
      1410       1420       1430       1440       1450
FDLDGDNPEE IATIMVNNDF ILAIERESFV DQVREIIEKA DEMLSEDVSV 
      1460       1470       1480       1490       1500
EPEGEQGLES LQGKDDYGFS GSQKLEGEFK QPIPSSSMPQ QIGIPTSSLT 
      1510       1520       1530       1540       1550
QVVHSAGRRF IVSPVPESRL RESKVFTSET SDTVAASTSH GTGMNLSHSA 
      1560       1570       1580       1590       1600
SSLSLQQAFS ELRHTQMTEG PSTAPPNFSH TGPTFPVVPP SMTSIAGVPT 
      1610       1620       1630       1640       1650
TAAATPSVSV SATSCPLNDI STSVIQSEIT VPTEKGIAGV ATCTGVITSS 
      1660       1670       1680       1690       1700
GLPVPPASES PVLSSVVSSI TIPAVVSIST TSQSVQAPTS GSIVSSIGTL 
      1710       1720       1730       1740       1750
PSVPVSTTSA STVGSAAAPG AKPPPVLSQQ AAGSTTGIAT LTSVSTTTPF 
      1760       1770       1780       1790       1800
PSIASQPAFQ LSSSTSAPTL AETVVISAHS LDKTSHSSAT GLALSLSASS 
      1810       1820       1830       1840       1850
SSPGAGVSSS ISQPSGVHPL VIQSAVASTP VLPQAAGPTS TPLLPQVPSI 
      1860       1870       1880       1890       1900
PPLVQPVASV PAVQQTLIHS QPQPALLPNQ PHTHCPEIDA DTQPKAPGID 
      1910       1920       1930       1940       1950
DIKTLEEKLR SLFSEHSSSG AQHASVSLET SLVVETTVTP GIPTTAVAPS 
      1960       1970       1980       1990       2000
KLMTSTTSTC LPPTSLPLGT TGLSVIPVVT PGQVSTPVSY VSAPVSSTPG 
      2010       2020       2030       2040       2050
VKPGTTPSKP SLTKAPVLPV GTELPAGTLP SDQLPPFPGP SLTQQPLEDL 
      2060       2070       2080       2090       2100
DAQLRRTLSP ETVAVTSAVG PVSVVAPTAV TEAAAQPQKD VSQVTEGPVL 
      2110       2120       2130       2140       2150
ATTSGTGVFK MGRFQVSVAM DDAQKEGQSK SEDAKSVHFE SSTSESSVLS 
      2160       2170       2180       2190       2200
SSSPESTLVK PEPNSVTIHG ISSDVPDSAH KTPLLAAKSE TGQSTKVGRF 
      2210       2220       2230       2240       2250
QVTTTANKVG RFSVSRTEDK IAEAKKEGPM ASPPFMDLEQ ATLPAVIPKK 
      2260       2270       2280       2290       2300
EKPELSEPSH LNGPSSDLEA AFLSRDVDDG SGSPHSPHQL SSKSLPVQNL 
      2310       2320       2330       2340       2350
SQSLSNSFNS SYMSSDNESD IEDEDLKLEL RRLREKHLKE IQDLQSRQKH 
      2360       2370       2380       2390       2400
EIESLYTKLG KVPPAVIIPP AAPLSGRRRR PTKSKGSKSS RSSSLGNKSP 
      2410       2420       2430       2440       2450
QLSGNLSGQS SASVLHPQQT LHPPGHMPES GQNQLLQPLK PSPSSDNLYS 
      2460       2470       2480       2490       2500
AFTSDGAISV PSLSAPGQGC AKFNCASEQV TFKPGGRRTR FLSTPCLALW 
      2510       2520       2530       2540       2550
KMVKKVCPCN QLCRTSSTNT VGGTVNSQAA QAQPPAMTSS RKGTFTDDLH 
      2560       2570       2580       2590       2600
KLVDNWARDA MNLSGRRGSK GHMNYEGPGM ARKFSAPGQL CISMTSNLGG 
      2610       2620       2630       2640       2650
SAPISAASAT SLGHFTKSMC PPQQYGFPAP PFGTQWSGTG GPAPQPLGQF 
      2660       2670       2680 
QPVGTASLQN FNISNLQKSI SNPPGSNLRT T
Length:2,681
Mass (Da):284,630
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B33C0377637F460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2ID61A0A3Q2ID61_HORSE
Non-specific serine/threonine prote...
WNK1
2,881Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C849F7C849_HORSE
Non-specific serine/threonine prote...
WNK1
2,393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BY14F7BY14_HORSE
Non-specific serine/threonine prote...
WNK1
2,585Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C2Q9F7C2Q9_HORSE
Non-specific serine/threonine prote...
WNK1
2,421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HGQ1A0A3Q2HGQ1_HORSE
Non-specific serine/threonine prote...
WNK1
2,398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HSN6A0A3Q2HSN6_HORSE
Non-specific serine/threonine prote...
WNK1
2,795Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HYK6A0A3Q2HYK6_HORSE
Non-specific serine/threonine prote...
WNK1
2,349Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IC89A0A3Q2IC89_HORSE
Non-specific serine/threonine prote...
WNK1
2,290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000025469; ENSECAP00000021187; ENSECAG00000023501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000025469; ENSECAP00000021187; ENSECAG00000023501

Organism-specific databases

VGNCiVGNC:52460, WNK1

Phylogenomic databases

GeneTreeiENSGT00940000155474

Gene expression databases

BgeeiENSECAG00000023501, Expressed in brainstem and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7BX86_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7BX86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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