Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 43 (02 Dec 2020)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
Add a publicationFeedback
Protein

Non-specific serine/threonine protein kinase

Gene

WNK1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:52460, WNK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000023501, Expressed in brainstem and 23 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 478Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni93 – 202DisorderedSequence analysisAdd BLAST110
Regioni572 – 690DisorderedSequence analysisAdd BLAST119
Regioni1128 – 1162DisorderedSequence analysisAdd BLAST35
Regioni1202 – 1371DisorderedSequence analysisAdd BLAST170
Regioni1531 – 1550DisorderedSequence analysisAdd BLAST20
Regioni1708 – 1733DisorderedSequence analysisAdd BLAST26
Regioni1992 – 2014DisorderedSequence analysisAdd BLAST23
Regioni2121 – 2179DisorderedSequence analysisAdd BLAST59
Regioni2248 – 2323DisorderedSequence analysisAdd BLAST76
Regioni2366 – 2450DisorderedSequence analysisAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2327 – 2347Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15PolarSequence analysisAdd BLAST15
Compositional biasi23 – 37PolarSequence analysisAdd BLAST15
Compositional biasi48 – 64PolyampholyteSequence analysisAdd BLAST17
Compositional biasi96 – 116Pro-richSequence analysisAdd BLAST21
Compositional biasi138 – 152Pro-richSequence analysisAdd BLAST15
Compositional biasi572 – 588PolyampholyteSequence analysisAdd BLAST17
Compositional biasi589 – 629PolarSequence analysisAdd BLAST41
Compositional biasi636 – 690PolarSequence analysisAdd BLAST55
Compositional biasi1129 – 1151PolarSequence analysisAdd BLAST23
Compositional biasi1202 – 1296PolarSequence analysisAdd BLAST95
Compositional biasi1310 – 1344PolarSequence analysisAdd BLAST35
Compositional biasi1348 – 1368BasicSequence analysisAdd BLAST21
Compositional biasi1992 – 2012PolarSequence analysisAdd BLAST21
Compositional biasi2125 – 2139PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2140 – 2172PolarSequence analysisAdd BLAST33
Compositional biasi2284 – 2316PolarSequence analysisAdd BLAST33
Compositional biasi2387 – 2418PolarSequence analysisAdd BLAST32
Compositional biasi2425 – 2450PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155474

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F7BX86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGAAEKQGS TPSALFLSPP APAPKNGSSS DSSVGEKLGS VGTDAGTGRT
60 70 80 90 100
EEYRRRRHTM DKDSRGAAAT TTTTEHRFFR RSVICDSNAT ALELPGLPLP
110 120 130 140 150
LPPPSVAAPV PQSAPPEPHR EETSTAAAAA PGAQEPPAAA GPGEPPAAAP
160 170 180 190 200
VAAPAPSGTS RDRPGAQPSH EGSKEEPPPA RSGSGGASAK EPQEERSQQQ
210 220 230 240 250
DDIEELETKA VGMSNDGRFL KFDIEIGRGS FKTVYKGLDT ETTVEVAWCE
260 270 280 290 300
LQDRKLTKSE RQRFKEEAEM LKGLQHPNIV RFYDSWESTV KGKKCIVLVT
310 320 330 340 350
ELMTSGTLKT YLKRFKVMKI KVLRSWCRQI LKGLQFLHTR TPPIIHRDLK
360 370 380 390 400
CDNIFITGPT GSVKIGDLGL ATLKRASFAK SVIGTPEFMA PEMYEEKYDE
410 420 430 440 450
SVDVYAFGMC MLEMATSEYP YSECQNAAQI YRRVTSGVKP ASFDKVAIPE
460 470 480 490 500
VKEIIEGCIR QNKDERYSIK DLLNHAFFQE ETGVRVELAE EDDGEKIAIK
510 520 530 540 550
LWLRIEDIKK LKGKYKDNEA IEFSFDLERD VPEDVAQEMV ESGYVCEGDH
560 570 580 590 600
KTMAKAIKDR VSLIKRKREQ RQLVREEQEK RKQEESSLKQ QVEQQSSASQ
610 620 630 640 650
AGIKQLPSAS TSVPAASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL
660 670 680 690 700
SDGTIDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTL PGHTASVVQA
710 720 730 740 750
QSQPHGVYPP SSMPRRGRSM SVCVPHLSAV PFLSRISPSA PSTPPPVLSA
760 770 780 790 800
PLCPSLLRTA PEETFAEKLS KALESVLPMH SASQRKHRRS SLPSLFVSTP
810 820 830 840 850
QSMAHPCGGT PTYPESQIFF PTIHERPVSF SPPPTCPPKV AISQRRKSTS
860 870 880 890 900
FLEAQTHHFQ PLLRTVGQNL LPPGGSSTNW TPEAIVMLGT TANRITGEPC
910 920 930 940 950
EIQVHPMFEP TQVYSDYRPG LVLSEEAHYF IPQEAVYLAG AHYQTQVAEQ
960 970 980 990 1000
YEGIPYNSPV LSSHMKQIPE QKPVQGGPTS SSVFEFPSGQ AFLVGHLQNL
1010 1020 1030 1040 1050
RLDSGLSPGS PLSSISAPIS TDATRLKFHP IFVPHSAPAV LTHNNESRSN
1060 1070 1080 1090 1100
CVFEFHVHTP SSSSGEGGVL PQRVYRNLQV AVDLNQEEPP PQSVGLHGGL
1110 1120 1130 1140 1150
QPVTEEQHNY HAPELTVSVV EPIGQNWPIG SPEYSSDSSQ ITSSDPSDFQ
1160 1170 1180 1190 1200
SPPPTGGAAA PFGSDVSLPY IRLPQTVLQE SPLFFCFPQG TTSQQVLSAS
1210 1220 1230 1240 1250
VSSGGSALHP QAQGQSQGQP SSSSLTGIPS SQPIQHSQQQ QGIQQTAPPQ
1260 1270 1280 1290 1300
QTVQYSLPQT STSSETTTAQ PVSQPQAPQV LPQVSAGKQS TQGVAQVAPP
1310 1320 1330 1340 1350
EPIPVAQPQP TQPTTLVSSI DSAHSDVASG MSDGNENVPS SSGRHEGRTT
1360 1370 1380 1390 1400
KRHYRKSVRS RSRHEKTSRP KLRILNVSNK GDRVVECQLE THNRKMVTFK
1410 1420 1430 1440 1450
FDLDGDNPEE IATIMVNNDF ILAIERESFV DQVREIIEKA DEMLSEDVSV
1460 1470 1480 1490 1500
EPEGEQGLES LQGKDDYGFS GSQKLEGEFK QPIPSSSMPQ QIGIPTSSLT
1510 1520 1530 1540 1550
QVVHSAGRRF IVSPVPESRL RESKVFTSET SDTVAASTSH GTGMNLSHSA
1560 1570 1580 1590 1600
SSLSLQQAFS ELRHTQMTEG PSTAPPNFSH TGPTFPVVPP SMTSIAGVPT
1610 1620 1630 1640 1650
TAAATPSVSV SATSCPLNDI STSVIQSEIT VPTEKGIAGV ATCTGVITSS
1660 1670 1680 1690 1700
GLPVPPASES PVLSSVVSSI TIPAVVSIST TSQSVQAPTS GSIVSSIGTL
1710 1720 1730 1740 1750
PSVPVSTTSA STVGSAAAPG AKPPPVLSQQ AAGSTTGIAT LTSVSTTTPF
1760 1770 1780 1790 1800
PSIASQPAFQ LSSSTSAPTL AETVVISAHS LDKTSHSSAT GLALSLSASS
1810 1820 1830 1840 1850
SSPGAGVSSS ISQPSGVHPL VIQSAVASTP VLPQAAGPTS TPLLPQVPSI
1860 1870 1880 1890 1900
PPLVQPVASV PAVQQTLIHS QPQPALLPNQ PHTHCPEIDA DTQPKAPGID
1910 1920 1930 1940 1950
DIKTLEEKLR SLFSEHSSSG AQHASVSLET SLVVETTVTP GIPTTAVAPS
1960 1970 1980 1990 2000
KLMTSTTSTC LPPTSLPLGT TGLSVIPVVT PGQVSTPVSY VSAPVSSTPG
2010 2020 2030 2040 2050
VKPGTTPSKP SLTKAPVLPV GTELPAGTLP SDQLPPFPGP SLTQQPLEDL
2060 2070 2080 2090 2100
DAQLRRTLSP ETVAVTSAVG PVSVVAPTAV TEAAAQPQKD VSQVTEGPVL
2110 2120 2130 2140 2150
ATTSGTGVFK MGRFQVSVAM DDAQKEGQSK SEDAKSVHFE SSTSESSVLS
2160 2170 2180 2190 2200
SSSPESTLVK PEPNSVTIHG ISSDVPDSAH KTPLLAAKSE TGQSTKVGRF
2210 2220 2230 2240 2250
QVTTTANKVG RFSVSRTEDK IAEAKKEGPM ASPPFMDLEQ ATLPAVIPKK
2260 2270 2280 2290 2300
EKPELSEPSH LNGPSSDLEA AFLSRDVDDG SGSPHSPHQL SSKSLPVQNL
2310 2320 2330 2340 2350
SQSLSNSFNS SYMSSDNESD IEDEDLKLEL RRLREKHLKE IQDLQSRQKH
2360 2370 2380 2390 2400
EIESLYTKLG KVPPAVIIPP AAPLSGRRRR PTKSKGSKSS RSSSLGNKSP
2410 2420 2430 2440 2450
QLSGNLSGQS SASVLHPQQT LHPPGHMPES GQNQLLQPLK PSPSSDNLYS
2460 2470 2480 2490 2500
AFTSDGAISV PSLSAPGQGC AKFNCASEQV TFKPGGRRTR FLSTPCLALW
2510 2520 2530 2540 2550
KMVKKVCPCN QLCRTSSTNT VGGTVNSQAA QAQPPAMTSS RKGTFTDDLH
2560 2570 2580 2590 2600
KLVDNWARDA MNLSGRRGSK GHMNYEGPGM ARKFSAPGQL CISMTSNLGG
2610 2620 2630 2640 2650
SAPISAASAT SLGHFTKSMC PPQQYGFPAP PFGTQWSGTG GPAPQPLGQF
2660 2670 2680
QPVGTASLQN FNISNLQKSI SNPPGSNLRT T
Length:2,681
Mass (Da):284,630
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B33C0377637F460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2ID61A0A3Q2ID61_HORSE
Non-specific serine/threonine prote...
WNK1
2,881Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C849F7C849_HORSE
Non-specific serine/threonine prote...
WNK1
2,393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BY14F7BY14_HORSE
Non-specific serine/threonine prote...
WNK1
2,585Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C2Q9F7C2Q9_HORSE
Non-specific serine/threonine prote...
WNK1
2,421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HGQ1A0A3Q2HGQ1_HORSE
Non-specific serine/threonine prote...
WNK1
2,398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HSN6A0A3Q2HSN6_HORSE
Non-specific serine/threonine prote...
WNK1
2,795Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HYK6A0A3Q2HYK6_HORSE
Non-specific serine/threonine prote...
WNK1
2,349Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IC89A0A3Q2IC89_HORSE
Non-specific serine/threonine prote...
WNK1
2,290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000025469; ENSECAP00000021187; ENSECAG00000023501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000025469; ENSECAP00000021187; ENSECAG00000023501

Organism-specific databases

VGNCiVGNC:52460, WNK1

Phylogenomic databases

GeneTreeiENSGT00940000155474

Gene expression databases

BgeeiENSECAG00000023501, Expressed in brainstem and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7BX86_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7BX86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again