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Protein

Tetraspanin-15

Gene

Tspan15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:23035126, PubMed:26668317). Promotes ADAM10-mediated cleavage of (CDH2) (PubMed:26668317). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity).By similarity2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • protein localization to plasma membrane Source: MGI
  • protein maturation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-15
Short name:
Tspan-15
Alternative name(s):
Transmembrane 4 superfamily member 15
Gene namesi
Name:Tspan15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917673 Tspan15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 62ExtracellularSequence analysisAdd BLAST18
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 94CytoplasmicSequence analysisAdd BLAST11
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 235ExtracellularSequence analysisAdd BLAST120
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158121 – 294Tetraspanin-15Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiF7BWT7
PaxDbiF7BWT7
PeptideAtlasiF7BWT7
PRIDEiF7BWT7

PTM databases

iPTMnetiF7BWT7
PhosphoSitePlusiF7BWT7
SwissPalmiF7BWT7

Expressioni

Gene expression databases

BgeeiENSMUSG00000037031 Expressed in 191 organ(s), highest expression level in stomach
GenevisibleiF7BWT7 MM

Interactioni

Subunit structurei

Interacts with ADAM10; the interaction influences ADAM10 substrate specificity.2 Publications

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF7BWT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230655
HOVERGENiHBG106798
InParanoidiF7BWT7
KOiK17297
OMAiYCARLSY
OrthoDBiEOG091G0CHZ
TreeFamiTF313002

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: F7BWT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRGDSEQVR YCARFSYLWL KFSLIIYSTV FWLIGGLVLS VGIYAEAERQ
60 70 80 90 100
KYKTLESAFL APAIILILLG VVMFIVSFIG VLASLRDNLC LLQSFMYILG
110 120 130 140 150
ICLVMELIGG IVALIFRNQT IDFLNDNIRR GIENYYDDLD FKNIMDFVQK
160 170 180 190 200
KFKCCGGEDY RDWSKNQYHD CSAPGPLACG VPYTCCIRNT TDVVNTMCGY
210 220 230 240 250
KTIDKERLNA QNIIHVRGCT NAVLIWFMDN YTIMAGLLLG ILLPQFLGVL
260 270 280 290
LTLLYITRVE DIILEHSVTD GLLGPGAKSR TDTAGTGCCL CYPD
Length:294
Mass (Da):33,071
Last modified:February 22, 2012 - v2
Checksum:iBE1BFE47F255B6C8
GO
Isoform 2 (identifier: F7BWT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-294: TDVVNTMCGY...GTGCCLCYPD → MLSTPCVATKQSTRSA

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,361
Checksum:iED0DD76C329257AD
GO

Sequence cautioni

The sequence BAE42863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199G → D in BAE42863 (PubMed:16141072).Curated1
Sequence conflicti280R → S in BAE42863 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042389191 – 294TDVVN…LCYPD → MLSTPCVATKQSTRSA in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172169 mRNA Translation: BAE42863.1 Different initiation.
AC127417 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL32110.1
BC003872 mRNA Translation: AAH03872.1
CCDSiCCDS56705.1 [F7BWT7-1]
RefSeqiNP_932113.2, NM_197996.2 [F7BWT7-1]
UniGeneiMm.416781

Genome annotation databases

EnsembliENSMUST00000047883; ENSMUSP00000047029; ENSMUSG00000037031 [F7BWT7-1]
GeneIDi70423
KEGGimmu:70423
UCSCiuc007fgv.1 mouse [F7BWT7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172169 mRNA Translation: BAE42863.1 Different initiation.
AC127417 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL32110.1
BC003872 mRNA Translation: AAH03872.1
CCDSiCCDS56705.1 [F7BWT7-1]
RefSeqiNP_932113.2, NM_197996.2 [F7BWT7-1]
UniGeneiMm.416781

3D structure databases

ProteinModelPortaliF7BWT7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiF7BWT7
PhosphoSitePlusiF7BWT7
SwissPalmiF7BWT7

Proteomic databases

MaxQBiF7BWT7
PaxDbiF7BWT7
PeptideAtlasiF7BWT7
PRIDEiF7BWT7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047883; ENSMUSP00000047029; ENSMUSG00000037031 [F7BWT7-1]
GeneIDi70423
KEGGimmu:70423
UCSCiuc007fgv.1 mouse [F7BWT7-1]

Organism-specific databases

CTDi23555
MGIiMGI:1917673 Tspan15

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230655
HOVERGENiHBG106798
InParanoidiF7BWT7
KOiK17297
OMAiYCARLSY
OrthoDBiEOG091G0CHZ
TreeFamiTF313002

Miscellaneous databases

PROiPR:F7BWT7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037031 Expressed in 191 organ(s), highest expression level in stomach
GenevisibleiF7BWT7 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN15_MOUSE
AccessioniPrimary (citable) accession number: F7BWT7
Secondary accession number(s): C0H5X1, Q3TA07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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