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Protein
Submitted name:

Erythropoietin receptor

Gene

EPOR

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei125Required for ligand bindingUniRule annotation1
Sitei449Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei479Required for STAT1/STAT3 activationUniRule annotation1
Sitei508Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Erythropoietin receptorImported
Gene namesi
Name:EPORImported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei258 – 279HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500334900827 – 532Sequence analysisAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 72UniRule annotation
Disulfide bondi99 ↔ 115UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMODG00000006557

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei374Interaction with APS and STAT5, and activationUniRule annotation1
Sitei477Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000008137

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 252Fibronectin type-IIIInterPro annotationAdd BLAST98

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00920000149107
InParanoidiF7BUV5
KOiK05079
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

F7BUV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTGPPYWP GIGSICVLLS AGAAWATPAT QWELKHEPGL EGPLFESKVA
60 70 80 90 100
LLLAEEKEKP ICFTQRLEDL VCFWEEMASL GSKNYSFFYQ LDEEIWKLCM
110 120 130 140 150
LQVVWTGRGT IRYTCTFPLS DASSFIPVEL KVIATPPDME LRRTLYINEV
160 170 180 190 200
VFLDPPSGLT AQQMETPSQV ALRWLPPPMA QVTKDIHYEV KYSVAEGTWE
210 220 230 240 250
QRMDIQEGRT DCIIANLREH TRYVFTVRAK MAEPSYSGYW SSWSQPVTML
260 270 280 290 300
ITVDLDPLLL GLSVLLTCIL LLLVILALLR QRRFLKEMFW PGIPSPEPGF
310 320 330 340 350
KDLFTIHRGN FELWLGQSNA CLWWGPLSAY PEEPPARLEV LSERCWVAPA
360 370 380 390 400
AAREEEPLLV PERGRLAQGA KDDYLVLDAQ LLPHRPAAEP LRPSSFGLRG
410 420 430 440 450
SGSSTSRALG AEGDSAMETD AKSGSFSTAS ISALEPEHEE RGLASNFEYT
460 470 480 490 500
ILDPSSRLLC PRVSPPFPPP RPPDLKYLYL VVSDSGISAD YSSGDSQGAL
510 520 530
GSSPDGPYTN LYENSLLQPS SEPLPQSYLA CS
Length:532
Mass (Da):59,259
Last modified:July 27, 2011 - v1
Checksum:i290AB3F4409C838E
GO

Sequence databases

RefSeqiXP_001364395.1, XM_001364358.3

Genome annotation databases

EnsembliENSMODT00000008301; ENSMODP00000008137; ENSMODG00000006557
GeneIDi100010880
KEGGimdo:100010880

Similar proteinsi

Entry informationi

Entry nameiF7BUV5_MONDO
AccessioniPrimary (citable) accession number: F7BUV5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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