UniProtKB - F7BTN2 (F7BTN2_HORSE)
Protein
Myogenic factor
Gene
MYF5
Organism
Equus caballus (Horse)
Status
Functioni
Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.UniRule annotation
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- camera-type eye development Source: Ensembl
- cartilage condensation Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- extracellular matrix organization Source: Ensembl
- muscle tissue morphogenesis Source: Ensembl
- ossification Source: Ensembl
- positive regulation of myoblast differentiation Source: GO_Central
- positive regulation of myoblast fusion Source: GO_Central
- positive regulation of skeletal muscle fiber development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell-matrix adhesion Source: Ensembl
- skeletal muscle cell differentiation Source: GO_Central
- somitogenesis Source: Ensembl
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | DifferentiationARBA annotation, MyogenesisARBA annotation, Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Myogenic factorUniRule annotation |
Gene namesi | Name:MYF5Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20475, MYF5 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000020047, Expressed in embryo and 5 other tissues |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
UniRule annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 134 | BHLHInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 218 – 249 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 124 – 144 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 218 – 246 | PolarSequence analysisAdd BLAST | 29 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_066887_1_0_1 |
OMAi | SCQFSPS |
OrthoDBi | 1471470at2759 |
TreeFami | TF316344 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR022032, Myf5 IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit PF12232, Myf5, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
F7BTN2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMMDGCQFS PSEYFYDGSC IPSPEGDFGD EFEPRVAAFR AHKAELQGSD
60 70 80 90 100
EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS SFDSVYCPDV TNVYATEKSS
210 220 230 240 250
LSSLDCLSSI VDRITNSEQP GLPLQDPASL SPVASTDSQP ATPGASSSRL
IYHVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB608011 mRNA Translation: BAP59004.1 |
RefSeqi | NP_001289048.1, NM_001302119.1 |
Genome annotation databases
Ensembli | ENSECAT00000021416; ENSECAP00000017636; ENSECAG00000020047 |
GeneIDi | 100060703 |
KEGGi | ecb:100060703 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB608011 mRNA Translation: BAP59004.1 |
RefSeqi | NP_001289048.1, NM_001302119.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000021416; ENSECAP00000017636; ENSECAG00000020047 |
GeneIDi | 100060703 |
KEGGi | ecb:100060703 |
Organism-specific databases
CTDi | 4617 |
VGNCi | VGNC:20475, MYF5 |
Phylogenomic databases
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_066887_1_0_1 |
OMAi | SCQFSPS |
OrthoDBi | 1471470at2759 |
TreeFami | TF316344 |
Gene expression databases
Bgeei | ENSECAG00000020047, Expressed in embryo and 5 other tissues |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR022032, Myf5 IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit PF12232, Myf5, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7BTN2_HORSE | |
Accessioni | F7BTN2Primary (citable) accession number: F7BTN2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |