UniProtKB - F7BTM1 (F7BTM1_HORSE)
Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
USP2
Organism
Equus caballus (Horse)
Status
Functioni
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.UniRule annotation
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation EC:3.4.19.12
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
GO - Biological processi
- protein deubiquitination Source: UniProtKB-UniRule
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotation |
Biological process | Ubl conjugation pathwayUniRule annotation |
Protein family/group databases
MEROPSi | C19.013 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation) |
Gene namesi | Name:USP2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Expressioni
Gene expression databases
Bgeei | ENSECAG00000019869, Expressed in testis and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 268 – 600 | USPInterPro annotationAdd BLAST | 333 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 112 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 206 – 262 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 112 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 208 – 222 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 245 – 262 | PolarSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the peptidase C19 family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000161289 |
HOGENOMi | CLU_008279_1_2_1 |
InParanoidi | F7BTM1 |
OMAi | AYCKSPV |
TreeFami | TF106277 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F7BTM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQLSSTLKR YTESARYTDA PYAKSGYGTY TPSSYGANLA ASFLEKEKLG
60 70 80 90 100
FKPGPPTSLL TRPRTYGPSS ILDYDRSRPL LRPDIIGGGK RPESQTWGTE
110 120 130 140 150
RPSGSGLSGG SGFPYGVTNN SLSYLPVNAH NQGVTLTQKK SNSQSDLARD
160 170 180 190 200
FSSLRTSDSY RIDPGNLGRS PMLARTRKEL CALQGLYQAA SRSEYLSDYL
210 220 230 240 250
ENYGRKGSAP QVPSQTPPSR VPEVLSPTYR PSGRYTLWEK GKGQAPGSSR
260 270 280 290 300
SSSPGRDTMN SKSAQGLAGL RNLGNTCFMN SILQCLSNTR ELRDYCLQRL
310 320 330 340 350
YMRDLSHSSN AHTALMEEFA KLIQTIWTSS PNDVVSPSEF KTQIQRYAPR
360 370 380 390 400
FVGYNQQDAQ EFLRFLLDGL HNEVNRVTVR PKSNPENLDH LPDDEKGRQM
410 420 430 440 450
WRKYLEREDS RIGDLFVGQL KSSLTCTDCG YCSTVFDPFW DLSLPIAKRG
460 470 480 490 500
YPEVTLMDCM RLFTKEDVLD GDEKPTCCRC RARKRCIKKF SIQRFPKILV
510 520 530 540 550
LHLKRFSESR IRTSKLTTFV NFPLRDLDLR EFASENTNHA VYNLYAVSNH
560 570 580 590 600
SGTTMGGHYT AYCRSPVTGE WHTFNDSSVT PMSSSQVRTS DAYLLFYELA
SPPSRM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2I313 | A0A3Q2I313_HORSE | Ubiquitin carboxyl-terminal hydrola... | USP2 | 665 | Annotation score: | ||
A0A3Q2HNH4 | A0A3Q2HNH4_HORSE | Ubiquitin carboxyl-terminal hydrola... | USP2 | 396 | Annotation score: | ||
A0A3Q2HJV5 | A0A3Q2HJV5_HORSE | Ubiquitin specific peptidase 2 | USP2 | 362 | Annotation score: |
Sequence databases
RefSeqi | XP_005611699.1, XM_005611642.2 |
Genome annotation databases
Ensembli | ENSECAT00000021418; ENSECAP00000017638; ENSECAG00000019869 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005611699.1, XM_005611642.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C19.013 |
Proteomic databases
PaxDbi | F7BTM1 |
Genome annotation databases
Ensembli | ENSECAT00000021418; ENSECAP00000017638; ENSECAG00000019869 |
Phylogenomic databases
GeneTreei | ENSGT00940000161289 |
HOGENOMi | CLU_008279_1_2_1 |
InParanoidi | F7BTM1 |
OMAi | AYCKSPV |
TreeFami | TF106277 |
Gene expression databases
Bgeei | ENSECAG00000019869, Expressed in testis and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7BTM1_HORSE | |
Accessioni | F7BTM1Primary (citable) accession number: F7BTM1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |