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Protein
Submitted name:

Laminin subunit beta 2

Gene

LAMB2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Laminin subunit beta 2Imported
Gene namesi
Name:LAMB2Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:19566 LAMB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500334876636 – 1801Sequence analysisAdd BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi508 ↔ 522PROSITE-ProRule annotation
Disulfide bondi525 ↔ 537PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi786 ↔ 798PROSITE-ProRule annotation
Disulfide bondi788 ↔ 805PROSITE-ProRule annotation
Disulfide bondi807 ↔ 816PROSITE-ProRule annotation
Disulfide bondi834 ↔ 846PROSITE-ProRule annotation
Disulfide bondi836 ↔ 853PROSITE-ProRule annotation
Disulfide bondi855 ↔ 864PROSITE-ProRule annotation
Disulfide bondi899 ↔ 908PROSITE-ProRule annotation
Disulfide bondi959 ↔ 968PROSITE-ProRule annotation
Disulfide bondi1013 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1070 ↔ 1079PROSITE-ProRule annotation
Disulfide bondi1098 ↔ 1110PROSITE-ProRule annotation
Disulfide bondi1100 ↔ 1117PROSITE-ProRule annotation
Disulfide bondi1119 ↔ 1128PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1148 ↔ 1165PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiF7BK38
PRIDEiF7BK38

Expressioni

Gene expression databases

BgeeiENSECAG00000021805

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000019891

Structurei

3D structure databases

ProteinModelPortaliF7BK38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 285Laminin N-terminalInterPro annotationAdd BLAST240
Domaini286 – 349Laminin EGF-likeInterPro annotationAdd BLAST64
Domaini350 – 412Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini413 – 472Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini473 – 524Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini525 – 565Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini564 – 780Laminin IV type BInterPro annotationAdd BLAST217
Domaini786 – 833Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini834 – 879Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini880 – 929Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini930 – 988Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini989 – 1040Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1041 – 1097Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1098 – 1145Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1146 – 1192Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1204 – 1224Sequence analysisAdd BLAST21
Coiled coili1265 – 1299Sequence analysisAdd BLAST35
Coiled coili1480 – 1528Sequence analysisAdd BLAST49
Coiled coili1576 – 1620Sequence analysisAdd BLAST45
Coiled coili1635 – 1662Sequence analysisAdd BLAST28
Coiled coili1727 – 1782Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00780000121851
InParanoidiF7BK38
KOiK06243
OMAiGACICKH
OrthoDBiEOG091G009B
TreeFamiTF312903

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 9 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 4 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

F7BK38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERASGERGR DWRGQPAPWE LRLGLLLSVL ATALAQALAP DVPGCSRGSC
60 70 80 90 100
YPATGDLLVG RADRLTASST CGLHGPQPYC IVSHLQDEKK CFLCDSRRPF
110 120 130 140 150
SARDNPNSHR IQNVVTSFAP QRRAAWWQSE NGVPVVTIQL DLEAEFHFTH
160 170 180 190 200
LIMTFKTFRP AAMLVERSAD FGRTWHVYRY FSYDCGADFP GVPLAPPRHW
210 220 230 240 250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV
260 270 280 290 300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VVRGNCFCYG HASQCAPAPG
310 320 330 340 350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YHDLPWHPAE DGHSHACRKC
360 370 380 390 400
ECHGHAHSCH FDMAIYLASG NVSGGVCDGC QHNTAGHHCE LCRPFFYRDP
410 420 430 440 450
TKDLRDPAVC RSCDCDPMGS QDGGRCDPHD DPPLGLVSGQ CRCKEHVVGS
460 470 480 490 500
RCQQCRDGFF GLSASDPVGC RRCQCDARGT VPGGTPCDPN SGTCFCKRLV
510 520 530 540 550
TGHGCNRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCNEA TGQCRCRQHM
560 570 580 590 600
VGRRCEQVQP GYFRPFLDHL TWEAEDVQGQ VLDVVERLVI PGGAPSWTGL
610 620 630 640 650
GFVRLREGQA LEFLVASVPR AMDYDLLLRL EPQVPEQWAE MELTVQRPGP
660 670 680 690 700
VSAHSLCGHV LPKDDYIPGT LQSDTRYMVL PRPVCLEPGN SYKLHLKLVR
710 720 730 740 750
TGGSAQPDAP YSGPSLLIDS LVLLPRVLVL EMFSAGDAAA LERRATFERY
760 770 780 790 800
RCHEEGLLPS KTLPSEACAP LLISLSTLLY NGALPCQCDP QGSLSSECNP
810 820 830 840 850
HGGQCLCKPA VVGRRCDLCA PGYYGFGPTG CQACQCSPEG ALSSLCEGTS
860 870 880 890 900
GQCPCRPGAF GLRCDRCQRG QWGFPSCQPC VCNGHADECD THTGTCLGCR
910 920 930 940 950
DHTGGEHCER CIAGFYGDPR LPYGGQCRPC PCPEGPGSRQ HFATSCHQDG
960 970 980 990 1000
YSQQIVCHCR AGYTGLRCEA CAPGHFGDPS RPGGRCQPCE CSGNIDPMDP
1010 1020 1030 1040 1050
DACDPHTGQC LRCLHHTEGP HCAHCKPGFH GQAARQSCHR CTCNLLGTDP
1060 1070 1080 1090 1100
QQCPSTDRCN CDPSSGQCPC LPNVQGPSCD RCAPNFWNLA SGHGCQPCAC
1110 1120 1130 1140 1150
HPSRARGPTC NEFTGQCHCR AGFGGRTCSE CQELHWGDPG LQCRACDCDP
1160 1170 1180 1190 1200
RGIDTPQCHR STGHCSCRPG MSGVRCDQCA RGFSGVFPAC HPCHACFGDW
1210 1220 1230 1240 1250
DRVVQDLAAR TRRLEQRAQE LQQTGVLGAF ERSFWHMQEK LGTVQGIVGA
1260 1270 1280 1290 1300
RNTSAASTAQ FLEATEELRR EIGEATEHLT QLEAELTDVQ DENFNANHAL
1310 1320 1330 1340 1350
SSLERDGLAL NLTLRQLDQH LDLLKHSNFL GAYDSIRHAH SLSAEAERRA
1360 1370 1380 1390 1400
NTSALTVPSP VSNSAGIRHR TEVLMGAQRE DFNRKYMANQ QALGKLSART
1410 1420 1430 1440 1450
HTLSLTNINE LVCGPPGDAP CATSPCGGAG CRDEDGQPRC GGLSCNGAAA
1460 1470 1480 1490 1500
MADLALGRAR HTQAELQRAL AEGGGILSQV AETRRQAGEA QQQAQAALDK
1510 1520 1530 1540 1550
ANASRGQVEQ ANQELRELIQ SVKDFLSQEG ADPDSIEMVA TRVLELSIPA
1560 1570 1580 1590 1600
SPEQIQHLAG AIAERVRSLA DVDTILARTV GDVRRAEQLL QDARRARSRA
1610 1620 1630 1640 1650
EGEKQKAETV QAALEEAQRA QGAAQGAIQG AVVDTQDTEQ TLHQVQERMA
1660 1670 1680 1690 1700
GAEQALSSAG ERAQQLDGLL EALKLKRAGN SLAASSAEET AGSAQGRARE
1710 1720 1730 1740 1750
AEQLLQGPLG DQYQTVRALA ERKAQGVLAA QARAEQLRDE ARGLLQAAQD
1760 1770 1780 1790 1800
KLQRLQELEG TYEENERALE GKAAQLDGLE ARMRSVLQAI NLQVQIYNTC

Q
Length:1,801
Mass (Da):195,802
Last modified:July 27, 2011 - v1
Checksum:iF7D07C54210E52D1
GO

Sequence databases

RefSeqiXP_001498255.1, XM_001498205.5

Genome annotation databases

EnsembliENSECAT00000023969; ENSECAP00000019891; ENSECAG00000021805
GeneIDi100053539
KEGGiecb:100053539

Similar proteinsi

Entry informationi

Entry nameiF7BK38_HORSE
AccessioniPrimary (citable) accession number: F7BK38
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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