We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - F7BJK1 (F7BJK1_MOUSE)
Protein
Submitted name:
Protocadherin 1
Gene
Pcdh1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
Keywordsi
Ligand | CalciumPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protocadherin 1Imported |
Gene namesi | Name:Pcdh1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104692, Pcdh1 |
VEuPathDBi | HostDB:ENSMUSG00000051375 |
Subcellular locationi
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell junction Source: MGI
- cell-cell junction Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 692 – 713 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | F7BJK1 |
MaxQBi | F7BJK1 |
PeptideAtlasi | F7BJK1 |
PRIDEi | F7BJK1 |
ProteomicsDBi | 311988 |
PTM databases
GlyConnecti | 2647, 2 N-Linked glycans (1 site) |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051375, Expressed in Ammon's horn and 203 other tissues |
ExpressionAtlasi | F7BJK1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 119 | CadherinInterPro annotationAdd BLAST | 112 | |
Domaini | 120 – 226 | CadherinInterPro annotationAdd BLAST | 107 | |
Domaini | 235 – 345 | CadherinInterPro annotationAdd BLAST | 111 | |
Domaini | 346 – 451 | CadherinInterPro annotationAdd BLAST | 106 | |
Domaini | 452 – 554 | CadherinInterPro annotationAdd BLAST | 103 | |
Domaini | 572 – 683 | CadherinInterPro annotationAdd BLAST | 112 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 732 – 951 | DisorderedSequence analysisAdd BLAST | 220 | |
Regioni | 996 – 1077 | DisorderedSequence analysisAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 758 – 773 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 811 – 830 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 841 – 867 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 876 – 916 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 923 – 948 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1047 – 1068 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155521 |
HOGENOMi | CLU_006480_5_3_1 |
InParanoidi | F7BJK1 |
PhylomeDBi | F7BJK1 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013585, Protocadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 6 hits PF08374, Protocadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 6 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F7BJK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
NDNTPNFASP VITLAIPENT NIGSLFPIPL ATDRDAGPNG VASYELQAGP
60 70 80 90 100
EAQELFGLQV AEDQEEKQPQ LIVMGNLDRE RWDSYDLTIK VQDGGNPPRA
110 120 130 140 150
SSALLRVTVL DTNDNAPKFE RPTYEAELSE NSPIGHSVIQ VKANDSDQGA
160 170 180 190 200
NAEIDYTFHQ APEVVRRLLR LDRNTGLITV QGPVDREDLS TLRFSVLAKD
210 220 230 240 250
RGATPKSARA QVVVTVKDMN DNAPTIEIRG IGLVTHQDGM ANISEDVAEE
260 270 280 290 300
TAVALVQVSD RDEGENAAVT CVVAGDVPFQ LRQASETGSD SKKKYFLQTT
310 320 330 340 350
TPLDYEKVKD YTIEIVAVDS GNPPLSSTNS LKVQVVDVND NAPVFTQSIT
360 370 380 390 400
EVAFPENNKP GEVVAEVTAS DADSGSNAEL VYSLEPEPAA QGLFTISPEN
410 420 430 440 450
GEIRVKTSLD REQRDSYELK VVAADRGSPS LQGTATVLVN VLDCNDNDPK
460 470 480 490 500
FMLSGYNFSV MENMPALSPV GMVTVIDGDK GENARVQLSV EQDNGDFVIQ
510 520 530 540 550
NGTGTILSSL SFDREQQSTY TFQLKAVDGG VPPRSAYVGV TINVLDENDN
560 570 580 590 600
APFITAPSNT SHRLLTPQTR LGETVSQVTA EDIDSGINAE LTYSIAGGNP
610 620 630 640 650
YGLFQIGSHS GAITLEKEIE RRHHGLHRLV VKVSDRGKPP RYGTALVHLY
660 670 680 690 700
VNETLANRTL LETLLVHSLD TPLDIDIAGD PEYERSKQRG NILFGVVAGV
710 720 730 740 750
VAVALLIALA VLVRYCRQRE AKSGYQAGKK ETKDLYAPKP SGKAAKGSKS
760 770 780 790 800
KGKKSKSPKP VKPVEDEDDT GLQKSLKFNL MSDAPGDSPR IHLPLNYPPG
810 820 830 840 850
SPDLGRHYRS NSPLPSIQLQ PQSPSASKKH QVVQDLPPAN TFVGTGDTTS
860 870 880 890 900
TGSEQYSDYS YRTNPPKYPS KQLPHRRVTF SATSQAQELQ DPSQHSYYDS
910 920 930 940 950
GLEESETPSS KSSSGPRLGP LALPEDHYER TTPDGSIGEM EHPENDLRPL
960 970 980 990 1000
PDVAMTGTCT RECSEFGHSD TCWMPGQSSP SRRTKSSALK LSTFVPYQDR
1010 1020 1030 1040 1050
GGQEPAGAGS PSPPEDRNTK TAPVRLLPSY SAFSHSSHDS CKDSATLEEI
1060 1070
PLTQTSDFPP TATPASAQTA AKREIYL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8CFX3 | Q8CFX3_MOUSE | Protocadherin 1 | Pcdh1 | 1,038 | Annotation score: | ||
E0CXD4 | E0CXD4_MOUSE | Protocadherin 1 | Pcdh1 | 360 | Annotation score: | ||
A0A0A6YX79 | A0A0A6YX79_MOUSE | Protocadherin 1 | Pcdh1 | 45 | Annotation score: | ||
A0A0A6YY88 | A0A0A6YY88_MOUSE | Protocadherin 1 | Pcdh1 | 60 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Genome annotation databases
Ensembli | ENSMUST00000161701; ENSMUSP00000125576; ENSMUSG00000051375 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | F7BJK1 |
ModBasei | Search... |
PTM databases
GlyConnecti | 2647, 2 N-Linked glycans (1 site) |
Proteomic databases
jPOSTi | F7BJK1 |
MaxQBi | F7BJK1 |
PeptideAtlasi | F7BJK1 |
PRIDEi | F7BJK1 |
ProteomicsDBi | 311988 |
Protocols and materials databases
Antibodypediai | 27376, 318 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENSMUST00000161701; ENSMUSP00000125576; ENSMUSG00000051375 |
Organism-specific databases
MGIi | MGI:104692, Pcdh1 |
VEuPathDBi | HostDB:ENSMUSG00000051375 |
Phylogenomic databases
GeneTreei | ENSGT00940000155521 |
HOGENOMi | CLU_006480_5_3_1 |
InParanoidi | F7BJK1 |
PhylomeDBi | F7BJK1 |
Miscellaneous databases
ChiTaRSi | Pcdh1, mouse |
RNActi | F7BJK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051375, Expressed in Ammon's horn and 203 other tissues |
ExpressionAtlasi | F7BJK1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013585, Protocadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 6 hits PF08374, Protocadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | F7BJK1_MOUSE | |
Accessioni | F7BJK1Primary (citable) accession number: F7BJK1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | January 19, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |