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Protein

MORC family CW-type zinc finger protein 3

Gene

Morc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (By similarity). Sumoylated MORC3-NBs can also associate with PML-NBs (By similarity). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri404 – 454CW-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 3By similarity
Alternative name(s):
Nuclear matrix protein 2By similarity
Zinc finger CW-type coiled-coil domain protein 3By similarity
Gene namesi
Name:Morc3Imported
Synonyms:Nxp2Imported, Zcwcc3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2136841 Morc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Lethality occurs at birth or within a day thereafter, for unknown reasons. Embryos at 14.5 dpc are morphologically indistinguishable from wild type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004351411 – 942MORC family CW-type zinc finger protein 3Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei517PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei563PhosphoserineCombined sources1
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki743Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki743Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei768PhosphoserineBy similarity1
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiF7BJB9
PaxDbiF7BJB9
PRIDEiF7BJB9

PTM databases

iPTMnetiF7BJB9
PhosphoSitePlusiF7BJB9

Expressioni

Gene expression databases

BgeeiENSMUSG00000039456 Expressed in 280 organ(s), highest expression level in lymph node
ExpressionAtlasiF7BJB9 baseline and differential
GenevisibleiQ6A0C2 MM

Interactioni

Subunit structurei

Homodimer. The sumoylated form interacts with PML (via SUMO-interacting motif). Interacts with PT53.1 Publication

Protein-protein interaction databases

IntActiF7BJB9, 3 interactors
STRINGi10090.ENSMUSP00000040152

Structurei

Secondary structure

1942
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliF7BJB9
SMRiF7BJB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 353Nuclear matrix bindingBy similarityAdd BLAST28
Regioni503 – 594RNA bindingBy similarityAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili696 – 874Sequence analysisAdd BLAST179

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri404 – 454CW-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG055625
InParanoidiF7BJB9
OrthoDBiEOG091G018P
TreeFamiTF329118

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F7BJB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQPPTGIR LSALCPKFLH TNSTSHTWPF SAVAELIDNA YDPDVNAKQI
60 70 80 90 100
WIDKTVISDH ICLTFTDNGN GMTADKLHKM LSFGFSDKVT MNGHVPVGLY
110 120 130 140 150
GNGFKSGSMR LGKDAMVFTK NGETMSVGFL SQTYLEVIKA EHVVVPIVTF
160 170 180 190 200
NKHRQMINLT ESKASLAAIL EHSLFSTEQK LLAELNAIMG KKGTRIIIWN
210 220 230 240 250
LRSYKNATEF DFEKDKYDIR IPEDLDETAG RKGYKKQERM DQIAPESDYS
260 270 280 290 300
LRAYCSILYL KPRMQIIIRG QKVKTQLVSK SLAYIERDVY RPKFLTRTVR
310 320 330 340 350
ITFGFNCRNK DHYGIMMYHK NRLIKAYEKV GCQLKANNMG VGVVGIIECN
360 370 380 390 400
FLKPTHNKQD FDYTNEYRLT ILALGEKLND YWNEMKVKKN AEYPVNLPVE
410 420 430 440 450
DIQKRPDQTW VQCDACLKWR KLPDGIDQLP EKWYCSNNPD PQFRNCEVPE
460 470 480 490 500
EPEDEDLVHP TYEKTYKKTS KERFRIRQPE ILPRILPQIN PELLYQTSVS
510 520 530 540 550
SQSFSPVKES VPRPHLSEVT SPFAARIINL NLASPASEPE NSSMKRKLGV
560 570 580 590 600
HSSILNAKTR RLSNPPVENS SYKNDDDEDV IILEENSTPK PAVDLEVKSD
610 620 630 640 650
IEVKSEQSHT EQSGIHVDLV SSPKPCVQAS STSTSTSRSD PGITVSTQTD
660 670 680 690 700
APGLTVKKEE SMEEDMGVRN GTATLSCVGT EAKVQETSAE SVDATSHQLQ
710 720 730 740 750
ELRSELLVVT QERDDYKRQC QMFTDQIQVL QQRLLEMNDK CVKKEKCHQS
760 770 780 790 800
TETDAVFLLD SVNGQAESLD HLGSQYQQAL QEIERLKRQC SALQQVKSEC
810 820 830 840 850
SQASCTESKS EVDEMAVQLD DVFRQLDKCT IERDQYKNEV QLLEIEKSHI
860 870 880 890 900
HSQCEELQTE VEQLKSTGQQ AAADGSTASN AEEPVSYVDG ESLKLRSLRV
910 920 930 940
NVGQLLAMIV PDLDLQQVNY DVDVVDEILG QVVEQMSEIS ST
Length:942
Mass (Da):106,522
Last modified:October 3, 2012 - v1
Checksum:i29EFFF22B7B24C94
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU83A0A0J9YU83_MOUSE
MORC family CW-type zinc finger pro...
Morc3
397Annotation score:
A0A0J9YUV3A0A0J9YUV3_MOUSE
MORC family CW-type zinc finger pro...
Morc3
92Annotation score:
A0A338P7B1A0A338P7B1_MOUSE
MORC family CW-type zinc finger pro...
Morc3
58Annotation score:

Sequence cautioni

The sequence BAD32174 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134Y → H in AAH98072 (PubMed:15489334).Curated1
Sequence conflicti679G → S in AAI45706 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172896 mRNA Translation: BAD32174.1 Different initiation.
AC168220 Genomic DNA No translation available.
BC098072 mRNA Translation: AAH98072.1
BC145705 mRNA Translation: AAI45706.1
BC026506 mRNA Translation: AAH26506.1
CCDSiCCDS79490.1
RefSeqiNP_001038994.2, NM_001045529.3
UniGeneiMm.287329

Genome annotation databases

EnsembliENSMUST00000044068; ENSMUSP00000040152; ENSMUSG00000039456
ENSMUST00000202261; ENSMUSP00000144369; ENSMUSG00000039456
GeneIDi338467
KEGGimmu:338467
UCSCiuc008aaa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172896 mRNA Translation: BAD32174.1 Different initiation.
AC168220 Genomic DNA No translation available.
BC098072 mRNA Translation: AAH98072.1
BC145705 mRNA Translation: AAI45706.1
BC026506 mRNA Translation: AAH26506.1
CCDSiCCDS79490.1
RefSeqiNP_001038994.2, NM_001045529.3
UniGeneiMm.287329

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IX1X-ray2.60A/B7-456[»]
5IX2X-ray2.90A/B7-456[»]
ProteinModelPortaliF7BJB9
SMRiF7BJB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiF7BJB9, 3 interactors
STRINGi10090.ENSMUSP00000040152

PTM databases

iPTMnetiF7BJB9
PhosphoSitePlusiF7BJB9

Proteomic databases

MaxQBiF7BJB9
PaxDbiF7BJB9
PRIDEiF7BJB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044068; ENSMUSP00000040152; ENSMUSG00000039456
ENSMUST00000202261; ENSMUSP00000144369; ENSMUSG00000039456
GeneIDi338467
KEGGimmu:338467
UCSCiuc008aaa.2 mouse

Organism-specific databases

CTDi23515
MGIiMGI:2136841 Morc3

Phylogenomic databases

eggNOGiKOG1845 Eukaryota
ENOG411033B LUCA
GeneTreeiENSGT00530000062983
HOGENOMiHOG000246950
HOVERGENiHBG055625
InParanoidiF7BJB9
OrthoDBiEOG091G018P
TreeFamiTF329118

Miscellaneous databases

ChiTaRSiMorc3 mouse
PROiPR:F7BJB9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039456 Expressed in 280 organ(s), highest expression level in lymph node
ExpressionAtlasiF7BJB9 baseline and differential
GenevisibleiQ6A0C2 MM

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR011124 Znf_CW
PfamiView protein in Pfam
PF07496 zf-CW, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050 ZF_CW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMORC3_MOUSE
AccessioniPrimary (citable) accession number: F7BJB9
Secondary accession number(s): A6H605
, Q4QQR6, Q6A0C2, Q8R0R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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