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Entry version 54 (05 Jun 2019)
Sequence version 2 (18 Apr 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7719 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008144 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 280PHInterPro annotationAdd BLAST108
Domaini654 – 834DHR-1InterPro annotationAdd BLAST181
Domaini1616 – 2044DHR-2InterPro annotationAdd BLAST429

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1257 – 1286DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1927 – 1954Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167752

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7BIX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAQHIGH

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7BIX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LTSNCLFITM PETRKFAQGL KRKGTATKRR ESATQAMRGS VYSRMKTAAS
60 70 80 90 100
EPVDYESYIV KRQSEIQHDT MRSLLSFPAD DVISTVKPRE RRTTIDTVPP
110 120 130 140 150
EATKEASGLF VKECIKTYTS NWSLIEHKYE AYASDYLHLP RGDGSEPLLQ
160 170 180 190 200
EQVFELDEEP DIDDDIASSH KEGVTKLGWL YKAPAYGVSG LSIRSFKRRY
210 220 230 240 250
FHLKQLPDNS YILNFYKDEK ISKDPKGAIY LDSCIGAHVT SKARKHAFEV
260 270 280 290 300
RMQDQSSHLL AADTESEAND WIATINLALQ SSIEAHVSQT LKNEHDKNGD
310 320 330 340 350
ECGLENPKSS MHPELVKYAR ETDQKNSLAR KEGRQNVIKL YPDFQPKHGK
360 370 380 390 400
APSTHVEPPA ILKSSVHRVL VDCKSISFTL RGVVIDGADE PVTNVEPFFV
410 420 430 440 450
TLALYDAQAG KKISADLHVD LNHPLVRRMV PNRQASHIKR SSTVSVETRT
460 470 480 490 500
GEPNLQVVDK EWVAHPKKGI FSVTNPHNEI FIVAKIEKVL QGSIKSCTQP
510 520 530 540 550
YMKSDGDNHK VAAKVLKHAK SACQRLGQYR MPFAWTAKPL FDNDKGHISN
560 570 580 590 600
TTFEYVYRQE SNKLAQEDLL KFLSDFKKPE KLSKLEYIEC ELQLGIDSVP
610 620 630 640 650
TDLPNILTSS YIPVKPYAPM TSSNQSMTSQ EPVLEVDEFL PTSASEQHIN
660 670 680 690 700
MEHTNHCYVY PKFLNYDNQK TFAKARNIAV VAEFRDSDAE GTKPLQSFYK
710 720 730 740 750
PPGMAGVGPF TTHVSAAVLH HNEKPEFYEE WKLSLPTQLH HGHHILFSFY
760 770 780 790 800
HVVVDTNAKK KESNQLEVGY AWLPLLTKDG RVGCGEHLIP VAGVLQPGYL
810 820 830 840 850
SLHEQLALGR VASPVMKWVV ISHIPRVVLA THVVPSPPFR RRHHLYPCSQ
860 870 880 890 900
PQRRLHSSVS RLINKSHRYI TQRHQTQSRV YITLSPTVRN EISKVFHAKH
910 920 930 940 950
LHGIQVTLSR RAIYTTRQSH QTTTHVSTLS YETSYFTTSR ITCSNFPSII
960 970 980 990 1000
NESCSTKIVN LIKQTTCSIL SFKIFASAWA RIITSYKHIC SHLISKLNSK
1010 1020 1030 1040 1050
SKTLPVRIRS SSEHHYLRFV ADYILQYIKQ HIMTNYSDVH NANLSLANFV
1060 1070 1080 1090 1100
KTCFTYLDRG FVFKLVNFYM ENFNPGDAKV LFELKFEFLQ IVCSHEHFIP
1110 1120 1130 1140 1150
LNLPFACSSK SARNDYSYCL SEDYCRIHFL TGLLMKNLCS ALYESPEIRS
1160 1170 1180 1190 1200
FAIETFRNIL AKHVFDDRWV XRQHQSRIAT LYLPYLRILL DNSSRDDLTE
1210 1220 1230 1240 1250
SSPMRGAGES SPALNNVFSL PPIGDRTGSL RARLPDNSVM SAISNVFNSH
1260 1270 1280 1290 1300
PIANPGSSLL TRGSRGSLAV SDNQNNTNTP PQPTSDKVSL HNFSSLIFGS
1310 1320 1330 1340 1350
LPRYPKFTAP EIRNLLLCFM HLLNNLPSDA LHGFWKDSTT DEQIDFFEVL
1360 1370 1380 1390 1400
EMCIHHFKYT GKKLIFAYHQ LNLTPHRFGS LSKLNKASHM IDEKELVRLT
1410 1420 1430 1440 1450
LLEANLSTEV GLIVLDMLAE FQRQFKKQLT SKEGDNRLMN KLFGAMLLFL
1460 1470 1480 1490 1500
QVSQSETVLK NAFASFRLLL CKFPSVLFRG SADLCASLIY YSLKCCNSQL
1510 1520 1530 1540 1550
ASLRSEACAL LYLLMRKNYD EGRPKKNFVR SHLQMIKSVS QLISEEVGIG
1560 1570 1580 1590 1600
SSRFQNSLSV INTYAISDKG MQSSTFPVEV KELTKKIRTV LMATAAMKEH
1610 1620 1630 1640 1650
KDDPEMLVDL QCSLAKSYAE NPELRKTWLE SMARVHKKNG NYSEVAMCYV
1660 1670 1680 1690 1700
HIAALVAEYL KRKGMLAKGC ALFRMISPNV EKEELAMKED SGMQDVPYNE
1710 1720 1730 1740 1750
DMLIDMLHTC VETLQQAERY ELLATIFAMI TPYYEKRRDY EVIINVYDTM
1760 1770 1780 1790 1800
KRGYEKVLEV NRNGKRLLGK FFRVALYGQS HFEEEDGKQY IYKEPKLTQL
1810 1820 1830 1840 1850
SEISQRLQAT YGSKYGSENV RLIQESGKVN TKELDSKLAY IQVTYVQPYF
1860 1870 1880 1890 1900
DEHEREQRTT YFEQQHNVRN FVFETPFTPG GRARGDIEEQ WKRKTILTTS
1910 1920 1930 1940 1950
HSFPYVKKRI PVMSMRSFEL KPIEVALDEM TSKCNELEQL ITAERVDLKK
1960 1970 1980 1990 2000
LQLRLQGSVN VQVNAGPLAY AKAFLEDSKV QNHAANTIEL LRGVFRRFVD
2010 2020 2030 2040
LCGRALYINE QLITSNQQVY HESLQECYLR TAAELSQILH EQVC
Length:2,044
Mass (Da):233,117
Last modified:April 18, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98119CA57D3ECA88
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EAAA01000035 Genomic DNA No translation available.
EAAA01000036 Genomic DNA No translation available.
EAAA01000037 Genomic DNA No translation available.
EAAA01000038 Genomic DNA No translation available.
EAAA01000039 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCINT00000005984; ENSCINP00000005984; ENSCING00000002933

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EAAA01000035 Genomic DNA No translation available.
EAAA01000036 Genomic DNA No translation available.
EAAA01000037 Genomic DNA No translation available.
EAAA01000038 Genomic DNA No translation available.
EAAA01000039 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCINT00000005984; ENSCINP00000005984; ENSCING00000002933

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000167752
InParanoidiF7BIX8
OMAiCAQHIGH
TreeFamiTF313629

Family and domain databases

Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7BIX8_CIOIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7BIX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 18, 2012
Last modified: June 5, 2019
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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