UniProtKB - F7B7X0 (F7B7X0_HORSE)
Protein
Cytokeratin-1
Gene
KRT1
Organism
Equus caballus (Horse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Cytokeratin-1ARBA annotationAlternative name(s): Keratin, type II cytoskeletal 1ARBA annotation Keratin-1ARBA annotation Type-II keratin Kb1ARBA annotation |
Gene namesi | Name:KRT1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19520, KRT1 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Cytoskeleton
- keratin filament Source: InterPro
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneARBA annotation, Intermediate filamentUniRule annotationARBA annotation, KeratinARBA annotation, MembranePTM / Processingi
Keywords - PTMi
CitrullinationARBA annotationProteomic databases
PaxDbi | F7B7X0 |
PRIDEi | F7B7X0 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022233, Expressed in zone of skin and 9 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 504 | IF rodInterPro annotationAdd BLAST | 314 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 555 – 626 | DisorderedSequence analysisAdd BLAST | 72 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 195 – 215 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 246 – 294 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 302 – 336 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 402 – 482 | Sequence analysisAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 587 – 626 | PolarSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000162175 |
HOGENOMi | CLU_012560_6_0_1 |
InParanoidi | F7B7X0 |
TreeFami | TF317854 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR032449, Keratin_2_1_tail IPR032444, Keratin_2_head IPR003054, Keratin_II |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF16208, Keratin_2_head, 2 hits PF16210, Keratin_2_tail, 1 hit |
PRINTSi | PR01276, TYPE2KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F7B7X0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRNFSSRSG RRIGGGFSSG SAGVVSFQRR TTSSSVCRGG GGGGGFSGGR
60 70 80 90 100
YGAGCAGGGF GSRSLVNLGG NKSISISVAR GGGRSGFGGG YGGGGFGVGG
110 120 130 140 150
YGGGGFGGGG FGSGGFGGGG FGSGGFGGGF GSGGFGGGFG SGGGFGGGGF
160 170 180 190 200
RGGFGPVCPP GGIQEVTINQ SLLQPLNVEI DPEIQRVKSQ EREQIKTLNN
210 220 230 240 250
QFASFIDKVR FLEQQNQVLQ TKWELLQQVD TPTRTQSLEP IFEAYISSLR
260 270 280 290 300
RQVDQLKSDQ SRMDSELKNM QDVVEDYRNK YEEEINKRTN AENEFVTIKK
310 320 330 340 350
DVDAAYITKV DLQAKVDNLR QEIEFLRILY QEELSQLQTH ISDTNVILSM
360 370 380 390 400
DNNRHLDLDS IIAEVRAQYE DIAQKSKAEA EALYQSKYEE LQITAGSHGD
410 420 430 440 450
SLKSTKMEIS ELNRVIQRLR SEIDSVKKQI AALQQSITEA EQRGENALKD
460 470 480 490 500
AQNKLNELED ALQRAKEDLA RLLRDYQELM STKLALDVEI ATYRTLLEGE
510 520 530 540 550
ESRMSGECAP NVSVSVSTSH TSISGGGVRG GGGFSSGGGG SYSSGGGSYS
560 570 580 590 600
SGGGGGGFGS GGSSRGHRGG SGGGGGSSGG WGSGGGGSGG SFSSSGGRGV
610 620
SSGGSKSSGG SSSVKFVSSS YSRGSR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PYS7 | A0A5F5PYS7_HORSE | Cytokeratin-1 | KRT1 | 626 | Annotation score: |
Sequence databases
RefSeqi | NP_001333128.1, NM_001346199.1 |
Genome annotation databases
Ensembli | ENSECAT00000024023; ENSECAP00000019935; ENSECAG00000022233 |
GeneIDi | 100063302 |
KEGGi | ecb:100063302 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001333128.1, NM_001346199.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F7B7X0 |
PRIDEi | F7B7X0 |
Genome annotation databases
Ensembli | ENSECAT00000024023; ENSECAP00000019935; ENSECAG00000022233 |
GeneIDi | 100063302 |
KEGGi | ecb:100063302 |
Organism-specific databases
CTDi | 3848 |
VGNCi | VGNC:19520, KRT1 |
Phylogenomic databases
GeneTreei | ENSGT00940000162175 |
HOGENOMi | CLU_012560_6_0_1 |
InParanoidi | F7B7X0 |
TreeFami | TF317854 |
Gene expression databases
Bgeei | ENSECAG00000022233, Expressed in zone of skin and 9 other tissues |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR042180, IF_rod_dom_coil1B IPR032449, Keratin_2_1_tail IPR032444, Keratin_2_head IPR003054, Keratin_II |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF16208, Keratin_2_head, 2 hits PF16210, Keratin_2_tail, 1 hit |
PRINTSi | PR01276, TYPE2KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7B7X0_HORSE | |
Accessioni | F7B7X0Primary (citable) accession number: F7B7X0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |