UniProtKB - F7B682 (F7B682_XENTR)
Protein
Submitted name:
Forkhead box protein F1
Gene
foxf1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 54 – 148 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- I-SMAD binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- BMP signaling pathway Source: GO_Central
- cell differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
- sprouting angiogenesis Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein F1Imported |
Gene namesi | Name:foxf1Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-478922, foxf1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Nucleus
- heteromeric SMAD protein complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSXETG00000003565, Expressed in embryo and 21 other tissues |
Interactioni
GO - Molecular functioni
- I-SMAD binding Source: GO_Central
- transcription factor binding Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 148 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 51 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 236 – 306 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 267 – 306 | PolarSequence analysisAdd BLAST | 40 |
Phylogenomic databases
GeneTreei | ENSGT00940000161035 |
HOGENOMi | CLU_039845_1_0_1 |
TreeFami | TF351598 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F7B682-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAEIQQPPS QPPAQSSPMS AATDKHGGQP SVMESANCAT KTKKTNAGIR
60 70 80 90 100
RPEKPPYSYI ALIVMAIQSS PTKRLTLSEI YQFLQSRFPF FRGSYQGWKN
110 120 130 140 150
SVRHNLSLNE CFIKLPKGLG RPGKGHYWTI DPASEFMFEE GSFRRRPRGF
160 170 180 190 200
RRKCQALKPM YSMMNGLGFN HIPETYSFQG ASGTIACPPN SLSLDSGIGM
210 220 230 240 250
MNGHLPSNVD GMGLSGHPVS HIAANGGHSY MGSCTGSSGG DYSHHDSGSP
260 270 280 290 300
LLGGGGVMEP HSVYSSPASA WAPSASTPYT KQQPLSPCNS AANPLSSSLS
310 320 330 340 350
SHSLDQSYLH QNSHNTASEL QGIPRYHSQS PSMNDRKEFV FSFNAMASSS
360 370
MHSGSGSYYH QQVGYQDIKP CVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ28BS5 | FOXF1_XENTR | Forkhead box protein F1 | foxf1 TNeu093i16.1 | 373 | Annotation score: |
Sequence databases
RefSeqi | XP_017946342.1, XM_018090853.1 |
Genome annotation databases
Ensembli | ENSXETT00000007706; ENSXETP00000007706; ENSXETG00000003565 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_017946342.1, XM_018090853.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSXETT00000007706; ENSXETP00000007706; ENSXETG00000003565 |
Organism-specific databases
Xenbasei | XB-GENE-478922, foxf1 |
Phylogenomic databases
GeneTreei | ENSGT00940000161035 |
HOGENOMi | CLU_039845_1_0_1 |
TreeFami | TF351598 |
Gene expression databases
Bgeei | ENSXETG00000003565, Expressed in embryo and 21 other tissues |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7B682_XENTR | |
Accessioni | F7B682Primary (citable) accession number: F7B682 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 2, 2020 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |