UniProtKB - F7B4V1 (F7B4V1_ORNAN)
Protein
Submitted name:
MYB proto-oncogene, transcription factor
Gene
MYB
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- chromatin remodeling Source: Ensembl
- mitotic cell cycle Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of histone H3-K4 methylation Source: Ensembl
- positive regulation of histone H3-K9 methylation Source: Ensembl
- positive regulation of T-helper cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MYB proto-oncogene, transcription factorImported |
Gene namesi | Name:MYBImported |
Organismi | Ornithorhynchus anatinus (Duckbill platypus)Imported |
Taxonomic identifieri | 9258 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Monotremata › Ornithorhynchidae › Ornithorhynchus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSOANG00000002777, Expressed in fibroblast and 7 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 142 | HTH myb-typeInterPro annotationAdd BLAST | 52 | |
Domaini | 143 – 198 | HTH myb-typeInterPro annotationAdd BLAST | 56 | |
Domaini | 199 – 249 | HTH myb-typeInterPro annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 474 – 495 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 351 – 371 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 28 | PolarSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156248 |
HOGENOMi | CLU_015440_2_2_1 |
InParanoidi | F7B4V1 |
OMAi | CGKTEEH |
TreeFami | TF326257 |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F7B4V1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLFTDFPL EDQPVSSSSS SSSSSSCSSC SSCSSCSSCS SSSCRRCCVR
60 70 80 90 100
GSARRRMARR PRPSIYSSDE DDEEIEMYDH DYDGLLPKAG KRHLGKTRWT
110 120 130 140 150
REEDEKLKKL VEQNGTDDWK VIANFLPNRT DVQCQHRWQK VLNPELIKGP
160 170 180 190 200
WTKEEDQRVI ELVQKYGPKR WSVIAKHLKG RIGKQCRERW HNHLNPEVKK
210 220 230 240 250
TSWTEEEDRI IYQAHKRLGN RWAEIAKLLP GRTDNAIKNH WNSTMRRKVE
260 270 280 290 300
QEGYLQESSK ANQPTVATSF QKNNHLMGFT HTPPSSQLPP TAQPPVANDY
310 320 330 340 350
SYYHISEAQN VPGQIPYPVA LHVNIVNVPQ PAAAAIQRHY NDEDPEKEKR
360 370 380 390 400
IKELELLLMS TENELKGQQA LPTQNHTSSY PAWHSTAMAD HARPHGDNAP
410 420 430 440 450
ISCLGDHHHS TPSPPVDHGC LPEESASPAR CMIVHQGNIL DNVKNLLEFA
460 470 480 490 500
ETLQLIDSDS SSWCDLSSFE FFEEADTPPS KPPSGKAVQL QPSRPEGYPS
510 520 530 540 550
TCLSKRILSQ GSLDSSKFLS TAKYSAAPLV ILHKKRGGHA SPLATGGNSS
560 570 580 590 600
FLLSDVNSST PKRSPVKSLP FSPSQFLNTS NSHENVDMDS PSLASTPLCG
610 620 630 640 650
HKLTVTTPFH RDQTLKPQKE NNIFRTPAIK RSIMESSPRT PTPFKNALAA
660 670 680 690 700
QEIKYGPLKM LPQTPSHLVE DLQDVIKQES DESGIVPGFH ENGPPLLKKI
710 720 730 740 750
KQEVESPTGK AGNFFCSNHW EGENLNTQLF NQGSPIEDVP NLLTSSVLMM
760 770 780 790 800
PVLEEEDSVL KAFAAPRNRS LATPLQHLSN TWEAVSCGKI EDQMIVSDQA
810
RKYINAFSTR TLVM
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8MZN5 | A0A6I8MZN5_ORNAN | MYB proto-oncogene, transcription f... | MYB | 778 | Annotation score: | ||
A0A6I8NV95 | A0A6I8NV95_ORNAN | MYB proto-oncogene, transcription f... | MYB | 697 | Annotation score: | ||
A0A6I8N6R7 | A0A6I8N6R7_ORNAN | MYB proto-oncogene, transcription f... | MYB | 555 | Annotation score: | ||
A0A6I8NID3 | A0A6I8NID3_ORNAN | MYB proto-oncogene, transcription f... | MYB | 604 | Annotation score: | ||
A0A6I8P5R4 | A0A6I8P5R4_ORNAN | MYB proto-oncogene, transcription f... | MYB | 300 | Annotation score: | ||
A0A6I8PGM2 | A0A6I8PGM2_ORNAN | MYB proto-oncogene, transcription f... | MYB | 779 | Annotation score: |
Genome annotation databases
Ensembli | ENSOANT00000004422; ENSOANP00000004421; ENSOANG00000002777 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9258.ENSOANP00000004421 |
Genome annotation databases
Ensembli | ENSOANT00000004422; ENSOANP00000004421; ENSOANG00000002777 |
Phylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT00940000156248 |
HOGENOMi | CLU_015440_2_2_1 |
InParanoidi | F7B4V1 |
OMAi | CGKTEEH |
TreeFami | TF326257 |
Gene expression databases
Bgeei | ENSOANG00000002777, Expressed in fibroblast and 7 other tissues |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7B4V1_ORNAN | |
Accessioni | F7B4V1Primary (citable) accession number: F7B4V1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 2, 2020 | |
Last modified: | February 10, 2021 | |
This is version 62 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |