UniProtKB - F7B4F3 (F7B4F3_HORSE)
Protein
Submitted name:
Presenilin associated rhomboid like
Gene
PARL
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- mitochondrial fusion Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of release of cytochrome c from mitochondria Source: Ensembl
- regulation of autophagy of mitochondrion Source: Ensembl
- regulation of mitochondrion organization Source: GO_Central
Protein family/group databases
MEROPSi | S54.009 |
Names & Taxonomyi
Protein namesi | Submitted name: Presenilin associated rhomboid likeImported |
Gene namesi | Name:PARLImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:57092, PARL |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Mitochondrion
- mitochondrial inner membrane Source: GO_Central
- mitochondrion Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 299 – 317 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 378 – 396 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 432 – 451 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 463 – 481 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000022422, Expressed in gluteus medius and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 343 – 484 | RhomboidInterPro annotationAdd BLAST | 142 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000013063 |
HOGENOMi | CLU_034022_0_1_1 |
InParanoidi | F7B4F3 |
OrthoDBi | 1554324at2759 |
TreeFami | TF313603 |
Family and domain databases
Gene3Di | 1.20.1540.10, 1 hit |
InterProi | View protein in InterPro IPR022764, Peptidase_S54_rhomboid_dom IPR035952, Rhomboid-like_sf |
Pfami | View protein in Pfam PF01694, Rhomboid, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F7B4F3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVPPFTSLG ATVNSDDNIY LKRFGRIKCN HLGKVPGPRH YSINASFVSS
60 70 80 90 100
FSTGPHAVEA GPLCHSAHTF RLSLVGRMAA PQLEPGDSDL SASARPRGGA
110 120 130 140 150
LGRSSALYGS SFAPEAVLRK GLVRSGHGGA EVGKMAWRGW VHRGWGCGQA
160 170 180 190 200
WAPPVGSRGC EELPAVLSPP RLLGRRFNFF IQQKCGFRKA PRKVEPRRSD
210 220 230 240 250
TGTSGEAYKR SALIPPVEET VFYPSPYPIR TLVKPLFFTV GFTGCAFGSA
260 270 280 290 300
AIWQYESLKS RVQSYFDGIK ADWLDSIRPQ KEGDFRKEIN KWWNNLSDGQ
310 320 330 340 350
RTVTGIIAAN VFVFCLWRVP SLQRTMVRYF TSNPASKVLC SPMLLSTFSH
360 370 380 390 400
FSLFHMAANM YVLWSFSSSI VNILGQEQFM AVYLSAGVIS TFVSYVCKVA
410 420 430 440 450
TGRYGPSLGA SGAIMTVLAA VCTKIPDGRL AIIFLPMFTF TAGNALKAII
460 470 480 490 500
AMDTAGMILG WKFFDHAAHL GGALFGIWYI TYGHELIWKN REPLVKIWHE
510
MRTNGPKKGG GSK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PGE3 | A0A5F5PGE3_HORSE | Presenilin associated rhomboid like | PARL | 329 | Annotation score: | ||
A0A5F5PTR7 | A0A5F5PTR7_HORSE | Presenilin associated rhomboid like | PARL | 295 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024029; ENSECAP00000019941; ENSECAG00000022422 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | S54.009 |
Proteomic databases
PaxDbi | F7B4F3 |
Genome annotation databases
Ensembli | ENSECAT00000024029; ENSECAP00000019941; ENSECAG00000022422 |
Organism-specific databases
VGNCi | VGNC:57092, PARL |
Phylogenomic databases
GeneTreei | ENSGT00390000013063 |
HOGENOMi | CLU_034022_0_1_1 |
InParanoidi | F7B4F3 |
OrthoDBi | 1554324at2759 |
TreeFami | TF313603 |
Gene expression databases
Bgeei | ENSECAG00000022422, Expressed in gluteus medius and 22 other tissues |
Family and domain databases
Gene3Di | 1.20.1540.10, 1 hit |
InterProi | View protein in InterPro IPR022764, Peptidase_S54_rhomboid_dom IPR035952, Rhomboid-like_sf |
Pfami | View protein in Pfam PF01694, Rhomboid, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F7B4F3_HORSE | |
Accessioni | F7B4F3Primary (citable) accession number: F7B4F3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |