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Protein

Cell division control protein

Gene

CDC6

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control proteinUniRule annotation
Gene namesi
Name:CDC6Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:16305 CDC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF7B3A5

Expressioni

Gene expression databases

BgeeiENSECAG00000009913 Expressed in 2 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000007993

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 351AAAInterPro annotationAdd BLAST154
Domaini469 – 549Cdc6_CInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2227 Eukaryota
COG1474 LUCA
GeneTreeiENSGT00530000063498
InParanoidiF7B3A5
OMAiTGWPTDQ
OrthoDBiEOG091G0AXO
TreeFamiTF101051

Family and domain databases

CDDicd08768 Cdc6_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR016314 Cdc6/18
IPR015163 Cdc6_C
IPR027417 P-loop_NTPase
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF09079 Cdc6_C, 1 hit
PIRSFiPIRSF001767 Cdc6, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01074 Cdc6_C, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

F7B3A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CVAIMPQTRS QSQATISFPK KKLSRTLDKA KNSSDTKVAL TNVQATPRPP
60 70 80 90 100
CVKILPLSPR KRLGDDNLCN TPHLPPCSPP KQGKKENGPP RSHVPKGRRL
110 120 130 140 150
VFDNQLTIKS PSKREQARGR QNKIHSSVQK GQDITTNSEQ RCPLEKESAC
160 170 180 190 200
VRLFKQEGTC YQQAKLVLNT AVPDRLPARE KEMNVIRNFL REHICGKKAG
210 220 230 240 250
SLYLSGAPGT GKTACLSRIL QDLKKELKGF KTIMLNCMSL RSAQAVFPAI
260 270 280 290 300
AQEICQEGVS RPAGKDMMRK LENHMTAEKG PMIVLVLDEM DQLDSKGQDV
310 320 330 340 350
LYTLFEWPWL SNSRLVLIGI ANTLDLTDRI LPRLQAREKC KPRLLNFPPY
360 370 380 390 400
TKNQIATILQ DRLNQVSRDW VVDDAAIQFC ARKVSAVSGD VRKALDVCRR
410 420 430 440 450
AIEIVESDVK SQTILKPLSE CKSPSESLVP KQVGLIHISQ VISEVDGNRM
460 470 480 490 500
TLSREGAQDS FPLQQKILVC SLLLLTRQLK IKEVTLGKLY EAYSNVCRKQ
510 520 530 540 550
QVAAVDQSEC LSLSGLLEAR GILGLKKNKE TRFTKVSLKI EEKEIERALK
560
DKALIGNILA IGLP
Length:564
Mass (Da):62,889
Last modified:July 27, 2011 - v1
Checksum:iCF34801FB58EDD32
GO

Genome annotation databases

EnsembliENSECAT00000010369; ENSECAP00000007993; ENSECAG00000009913

Similar proteinsi

Entry informationi

Entry nameiF7B3A5_HORSE
AccessioniPrimary (citable) accession number: F7B3A5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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