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Protein
Submitted name:

Uncharacterized protein

Gene

MDM2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:MDM2Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

ExpressionAtlasiF7AJW7 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 276RanBP2-typeInterPro annotationAdd BLAST30
Domaini386 – 427RING-typeInterPro annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 185Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGXG Eukaryota
ENOG41125MP LUCA
GeneTreeiENSGT00530000063539

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15 PTHR13844:SF15, 2 hits
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500700 MDM2, 2 hits
PIRSF006748 p53_MDM_2/4, 2 hits
SUPFAMiSSF47592 SSF47592, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

F7AJW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY
110 120 130 140 150
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS
160 170 180 190 200
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC
210 220 230 240 250
VIREICCERS SSSESTGTPS NPVYRVTVYQ AGESDTDSFE EDPEISLADY
260 270 280 290 300
WKCTSCNEMN PPLPSHCNRC WALRENWLPE DKGKDKGEIS EKAKLENSTQ
310 320 330 340 350
AEEGFDVPDC KKTIVNDSKE SCVEENDDKI TQASQSQESE DYSQPSTSSS
360 370 380 390 400
IIYSSQEDVK EFEREETQDK EESVESSLPL NAIEPCVICQ GRPKNGCIVH
410 420 430
GKTGHLMACF TCAKKLKKRN KPCPVCRQPI QMIVLTYFP
Length:439
Mass (Da):49,435
Last modified:November 30, 2016 - v1
Checksum:iBC1D1C119CB354E5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9FUJ1H9FUJ1_MACMU
E3 ubiquitin-protein ligase Mdm2
MDM2
497Annotation score:
F7AKR9F7AKR9_MACMU
E3 ubiquitin-protein ligase Mdm2
MDM2
466Annotation score:
F7AJY5F7AJY5_MACMU
E3 ubiquitin-protein ligase Mdm2
MDM2
458Annotation score:
F7AJZ5F7AJZ5_MACMU
Uncharacterized protein
MDM2
413Annotation score:
F7AKW0F7AKW0_MACMU
Uncharacterized protein
MDM2
442Annotation score:
F7AKN6F7AKN6_MACMU
Uncharacterized protein
MDM2
369Annotation score:
F7AKU4F7AKU4_MACMU
Uncharacterized protein
MDM2
321Annotation score:
F7AKP5F7AKP5_MACMU
Uncharacterized protein
MDM2
243Annotation score:
F7AKT6F7AKT6_MACMU
Uncharacterized protein
MDM2
296Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03007143 Genomic DNA No translation available.
JSUE03007144 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMMUT00000019927; ENSMMUP00000018653; ENSMMUG00000014193

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03007143 Genomic DNA No translation available.
JSUE03007144 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000019927; ENSMMUP00000018653; ENSMMUG00000014193

Phylogenomic databases

eggNOGiENOG410IGXG Eukaryota
ENOG41125MP LUCA
GeneTreeiENSGT00530000063539

Gene expression databases

ExpressionAtlasiF7AJW7 baseline

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028340 Mdm2
IPR015459 MDM2_E3_ligase
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15 PTHR13844:SF15, 2 hits
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500700 MDM2, 2 hits
PIRSF006748 p53_MDM_2/4, 2 hits
SUPFAMiSSF47592 SSF47592, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF7AJW7_MACMU
AccessioniPrimary (citable) accession number: F7AJW7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: October 10, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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