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Entry version 74 (12 Aug 2020)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1

Gene

Macf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4999 – 5010PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi5035 – 5046PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108559, Macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneARBA annotation, Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, Membrane, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
F7ACR9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F7ACR9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F7ACR9

PeptideAtlas

More...
PeptideAtlasi
F7ACR9

PRoteomics IDEntifications database

More...
PRIDEi
F7ACR9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
F7ACR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028649, Expressed in lung and 330 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F7ACR9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F7ACR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 87Calponin-homology (CH)InterPro annotationAdd BLAST87
Domaini100 – 204Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini774 – 831SH3InterPro annotationAdd BLAST58
Domaini4986 – 5021EF-handInterPro annotationAdd BLAST36
Domaini5022 – 5057EF-handInterPro annotationAdd BLAST36
Domaini5062 – 5134GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4893 – 4924DisorderedSequence analysisAdd BLAST32
Regioni5150 – 5333DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili151 – 171Sequence analysisAdd BLAST21
Coiled coili383 – 403Sequence analysisAdd BLAST21
Coiled coili408 – 435Sequence analysisAdd BLAST28
Coiled coili727 – 747Sequence analysisAdd BLAST21
Coiled coili952 – 972Sequence analysisAdd BLAST21
Coiled coili1309 – 1339Sequence analysisAdd BLAST31
Coiled coili1428 – 1455Sequence analysisAdd BLAST28
Coiled coili1535 – 1562Sequence analysisAdd BLAST28
Coiled coili1688 – 1726Sequence analysisAdd BLAST39
Coiled coili1953 – 1980Sequence analysisAdd BLAST28
Coiled coili1987 – 2007Sequence analysisAdd BLAST21
Coiled coili2027 – 2054Sequence analysisAdd BLAST28
Coiled coili2065 – 2085Sequence analysisAdd BLAST21
Coiled coili2093 – 2120Sequence analysisAdd BLAST28
Coiled coili2133 – 2160Sequence analysisAdd BLAST28
Coiled coili2198 – 2218Sequence analysisAdd BLAST21
Coiled coili2463 – 2483Sequence analysisAdd BLAST21
Coiled coili2577 – 2597Sequence analysisAdd BLAST21
Coiled coili2670 – 2690Sequence analysisAdd BLAST21
Coiled coili2714 – 2734Sequence analysisAdd BLAST21
Coiled coili2821 – 2876Sequence analysisAdd BLAST56
Coiled coili3013 – 3033Sequence analysisAdd BLAST21
Coiled coili3039 – 3059Sequence analysisAdd BLAST21
Coiled coili3803 – 3823Sequence analysisAdd BLAST21
Coiled coili4036 – 4063Sequence analysisAdd BLAST28
Coiled coili4815 – 4835Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5169 – 5243PolarSequence analysisAdd BLAST75
Compositional biasi5280 – 5333PolarSequence analysisAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 4 hits
PTHR23169:SF24, PTHR23169:SF24, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 35 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

F7ACR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VRKHINDLYE DLRDGHNLIS LLEVLSGIKL PREKGRMRFH RLQNVQIALD
60 70 80 90 100
FLKQRQVKLV NIRNDDITDG NPKLTLGLIW TIILHFQISD IYISGESGDM
110 120 130 140 150
SAKEKLLLWT QKVTAGYTGV KCTNFSSCWS DGKMFNALIH RYRPDLVDME
160 170 180 190 200
RVQVQSNREN LEQAFEVAER LGVTRLLDAE DVDVPSPDEK SVITYVSSIY
210 220 230 240 250
DAFPKVPEGG EGISATEVDS RWQEYQSRVD SLIPWIRQHT ILMSDKSFPQ
260 270 280 290 300
NPVELKALYN QYIHFKETEI LAKEREKGRI KELYKLLEVW IEFGRIKLPQ
310 320 330 340 350
GYHPNHVEEE WGKLIVEMLE REKSLRPAVE RLELLLQIAN KIQNGALNCE
360 370 380 390 400
EKLTLAKNTL QADAAHLESG QPVQCESDVI MYIQECEGLI RQLQVDLQIL
410 420 430 440 450
RDEKYYQLEE LAFRVMRLQD ELVTLRLECT NLYRKGHFSS LELVPPSTLT
460 470 480 490 500
TTHLKAEPLN KTTHSSSTSW FRKPMTRTEL VSISSSEDEG NLRFVYELLS
510 520 530 540 550
WVEEMQMKLE RAEWGNDLPS VELQLETQQH IHTSVEELGS SVKEARLYEG
560 570 580 590 600
KMSQNFHTSY VETLGKLETQ YCKLKETSSF RMRHLQSLHK FVSRATAELI
610 620 630 640 650
WLNGKEEEEL ACDWSDSNPN ISAKKTYFSE LTMELEGKQD VFRSLQDTAE
660 670 680 690 700
VLSLENHPAK QTVEAYSAAV QSQLQWMKQL CLCVEQHVKE NAAYFQFFSD
710 720 730 740 750
ARDLESFLRN LQDSIKRKYT CDRSTSLSRL EDLLQDSMDE KEQLIQSKSS
760 770 780 790 800
VASLVGRSKT IVQLKPRNPD HVLKSTLSVK AICDYRQIEI TICKNDECVL
810 820 830 840 850
EDNSQRTKWK VISPTGNEAM VPSVCFLIPP PNKEAIEMAS RVEQSYQKVM
860 870 880 890 900
ALWHQLHINT KSLISWNYLR KDLDTVQTWS LEKLRSLAPG ECHQVMKNLQ
910 920 930 940 950
AHYEDFLQDS HDSALFSVAD RLRIEEEVEA CKAHFQHLMK SLENEDKEET
960 970 980 990 1000
LAKVYISELK NIRLLLEECE QRLLKQIQSP ASSKTDRDAR QDITLRIAEQ
1010 1020 1030 1040 1050
EHTQEDLQHL RSDLDAISMK CNVFLQQSPS GSSATTLRSE LNLMVEKMDH
1060 1070 1080 1090 1100
VYGLSTVYLN KLKTIDVIVR SMQDAELLVK GYEIKLSQEE AVPADLSALE
1110 1120 1130 1140 1150
SHRTTLQHWL SDVKDKNSVF SVLDEEITKA KKVAEQLRHP ASEPNLDLER
1160 1170 1180 1190 1200
YQEKGSQLQE RWHRVIAQLE TRQSEVESIQ EVLRDYRACH GTLIKWIEET
1210 1220 1230 1240 1250
TAQQEMMKPG QAEDSRVLSE QLSQQTELFA EIERNQTKLD QCQKFSQQYS
1260 1270 1280 1290 1300
TIVKDYELQL MTYKAFVESQ QKSPGKRRRM ISSSDAITQE FMDLRTRYTA
1310 1320 1330 1340 1350
LVTLTTQHVK YISDALRRLE EEEKVVEEEK QEHVEKVKDL LGWVSTLARN
1360 1370 1380 1390 1400
TQGTTTSSHT SASADIEKAI LEQQVLAEEL TTKKEQVSEA IKTSQIFLAK
1410 1420 1430 1440 1450
HGHKLSEGEK EQISEQLRVL NKTYHDLCDG SANQLQQLQS ELAQQTEQKT
1460 1470 1480 1490 1500
LQKQQDTCHK KLEDLCNWVG QAERALERHQ GGASRQELPA LQQNQSDLKD
1510 1520 1530 1540 1550
LQGDIQSHST SFATAVKDIE GFLEENQTKL SPQELTALRE KLHQAKEQYE
1560 1570 1580 1590 1600
VLQERTRVAQ KELEEAVTSA LQQETEKSKA ATELAENKRK IDALLDWVAS
1610 1620 1630 1640 1650
VGSSERKPQA SLPGMEQFSG ACLEKQTLAA TDGHVDVNQV PETLDRQYEL
1660 1670 1680 1690 1700
MKARHQELLS QQQNFIVATQ SVQSFLDQHS HNLTPEERQK LQEKLGELKE
1710 1720 1730 1740 1750
QYAASLARSE AELKQTQALR DELQKFLQDH KEFENWLQQS ENELDSMHKG
1760 1770 1780 1790 1800
GSSPEALNSL LKRQGSFSED VISHKGDLRF VTISGQKVLE TENNFEEGQE
1810 1820 1830 1840 1850
PSATRNLVNE KLKDATERYT TLHSKCIRLG SHLSMLLGQY QQFQSSADSL
1860 1870 1880 1890 1900
QAWVLTCEAS VGKLLSDTVA SDPGVLQQQL ATTKQLQEEL AEHQVPVEKL
1910 1920 1930 1940 1950
QKAAHDLLDI EGEPALDCRP IQETTDSISS RFQNLSCSLD ERSALLQKAI
1960 1970 1980 1990 2000
AQSQSVQESM ESLLQSIREV EQNLERDQVA SLSSGVIQEA LANNMKLKQD
2010 2020 2030 2040 2050
IARQKSSLEA THDMVTRFME TADSNSASVL QGKLAELSQR FQQLQLQQQE
2060 2070 2080 2090 2100
KESNLKKLLP QAEMFEQLSN KLQQFMENKS RLLASGNQPD QDIAHFSQQI
2110 2120 2130 2140 2150
QELTLAMEDQ KENLDTLEHL VTTLGSCGFA LDLSQHQDKI QNLKKDFTEL
2160 2170 2180 2190 2200
QKTVQEREKD ASTCQEQLDE FRKLIRTFQK WLKETEGNVP PAKTFVSAKE
2210 2220 2230 2240 2250
LEKQIEHLKD LISDWESKGA LLGEINAKGT ALESLIMDIT APDSQAKTGS
2260 2270 2280 2290 2300
ILPPVGSSVG SVNGYHTCKD LTEIQCDMFD VNSKYEKLWE VLRERQESLQ
2310 2320 2330 2340 2350
TVFSRMEEVQ KEASSVLQWL ESKEEVLKAM DATLSPTKTE TVKAQAESNK
2360 2370 2380 2390 2400
AFLAELEQNS PKIQKVKEAL AGLLKTYPNS QEAENWKKMQ EDLNSRWEKA
2410 2420 2430 2440 2450
TEVTVARQKQ LEESASHLAC FQAAESQLRP WLMEKELMMG VLGPLSIDPN
2460 2470 2480 2490 2500
MLNAQKQQVQ FMLKEFEARR QQHEQLNEAA QGILTGPGDM SPSASQVHKD
2510 2520 2530 2540 2550
LQSISQKWVE LTDKLNSRSS QIDQAIVKST QYQDLLQDLS EKVKAIGQRL
2560 2570 2580 2590 2600
SGQSAISTQP EAVKQQLEET SEIRSDLGQL DNEIKEAQTL CQELSLLIGE
2610 2620 2630 2640 2650
QYLKDELKKR LETVALPLQG LEDLAADRMN RLQAALASTQ QFQQMFDELR
2660 2670 2680 2690 2700
TWLDEKQSQQ AKNCPISAKL ERLQCQLQEN EEFQKNLNQH SGSYEVIVAE
2710 2720 2730 2740 2750
GEALLLSVPP GEEKKTLQNQ LVELRSHWED LSKKTANRQS RLKDCMQKAQ
2760 2770 2780 2790 2800
KYQGHVEDLV PWIDECKSKM SELQVTLDPV QLESSLLRSK AMLNEAEKRR
2810 2820 2830 2840 2850
SLLEILNSAA DILINSSEID EDEIRDEKAG LNQNMDAITE ELQAKTSSLE
2860 2870 2880 2890 2900
EMTQRLKEFQ ESFKNIEKKV EGAKHQLEIF DALGSQACSN KNLEKLKAQQ
2910 2920 2930 2940 2950
EVLQALEPQV DYLRNFTQGL VEDAPDGSDA SPLVHQAEVA QQEFLEVKQR
2960 2970 2980 2990 3000
VSSSCLTMEN KLEGIGQFHC RVREMFSQLA DLDDELDGMG AIGRDTDSLQ
3010 3020 3030 3040 3050
SQIEDVRLFL NKIQALRFDI EDSEAECRKM LEEEGTLDLL GLKRELEALN
3060 3070 3080 3090 3100
KQCGKLTERG KVRQEQLELT LGRVEDFYRK LKALNDAATA AEEGEALQWI
3110 3120 3130 3140 3150
VGTEVDVINQ QLADFKLFQK DQVDPLQVKL QQVNGLGQGL IQSAGKNCDV
3160 3170 3180 3190 3200
QGLEHDMDEI NTRWNTLNKK VAQRIAQLQE ALLHCGKFQD ALEPLLSWLT
3210 3220 3230 3240 3250
DTEELIANQK PPSAEYKVVK AQIQEQKLLQ RLLDDRKATV DMLQAEGGRI
3260 3270 3280 3290 3300
AQSAELADRE KITGQLESLE RRWTDLLSKA AARQKQLEDI LVLAKQFHET
3310 3320 3330 3340 3350
AEPISDFLSV TEKKLANSEP VGTQTAKIHQ QIIRHKALEE EIENHATDVH
3360 3370 3380 3390 3400
QAVKIGQSLS SLTCPAEQGI MSEKLDSLQA RYSEIQDRCC RKASLLEQAL
3410 3420 3430 3440 3450
FNARLFGEDE VEVLNWLAEV EDKLSTVFVK DYRQDVLQKQ HADHLALNEE
3460 3470 3480 3490 3500
IINRKKNVDQ AIKNGQALLK QTTGEEVLLI QEKLDGIKTR YADITLTSSK
3510 3520 3530 3540 3550
ALRTLEQARQ LATKFHSTYE ELTGWLREAE EELAASGGQS PTGEQIPQFQ
3560 3570 3580 3590 3600
QRQKELKKEV MEHRLVLDTV NEVSHALLEL VPWRAREGLD KLVSDANEQY
3610 3620 3630 3640 3650
KLISDTVGQR VDEIDAAIQR SQQYEQAADA ELAWVAETKR KLMALGPIRL
3660 3670 3680 3690 3700
EQDQTTAQLQ VQKAFSIDII RHKDSMDELF SHRGEIFSTC GEEQKAVLQE
3710 3720 3730 3740 3750
KTECLIQQYE AVSLLNSERY ARLERAQVLV NQFWETYEEL SPWAEETLAL
3760 3770 3780 3790 3800
IAQLPPPAVD HEQLRQQQEE MRQLRESIAE HKPHIDKILK IGPQLKELNP
3810 3820 3830 3840 3850
EEGKMVEEKY QKAENMYAQI KDEVRQRALA LDEAVSQSAQ FHDKIEPMLE
3860 3870 3880 3890 3900
TLENLSSRLR MPPLIPAEVD KIRECISDNK SATVELEKLQ PSFEALKRRG
3910 3920 3930 3940 3950
EELIGRSQGA DKDLAAKEIQ DKLDQMVFFW EDIKARSEER EIKFLDVLEL
3960 3970 3980 3990 4000
AEKFWYDMAA LLTTIKDTQD IVHDLESPGI DPSIIKQQVE AAETIKEETD
4010 4020 4030 4040 4050
GLHEELEFIR ILGADLIFAC GETEKPEVKK SIDEMNNAWE NLNKTWKERL
4060 4070 4080 4090 4100
EKLEDAMQAA VQYQDTLQAM FDWLDNTVIK LCTMPPVGTD LNTVKDQLNE
4110 4120 4130 4140 4150
MKEFKVEVYQ QQIEMEKLNH QGELMLKKAT DETDRDIIRE PLTELKHLWE
4160 4170 4180 4190 4200
NLGEKIAHRQ HKLEGALLAL GQFQHALEEL MSWLTHTEEL LDAQRPISGD
4210 4220 4230 4240 4250
PKVIEVELAK HHVLKNDVLA HQATVATVNK AGSELLESSA GDDASSLRSR
4260 4270 4280 4290 4300
LETMNQCWES VLQKTEEREQ QLQSTLQQAQ GFHSEIEDFL LELNRMENQL
4310 4320 4330 4340 4350
SASKPTGGLP ETAREQLDTH MELHSQLRAK EEIYNQLLDK GRLMLLSRGD
4360 4370 4380 4390 4400
SGSGSKTEQS VALLEQKWHA VSSKVEERKS KLEEALSLAT EFQNSLQEFI
4410 4420 4430 4440 4450
NWLTLAEQSL NIASPPSLIL NTVLSQIEEH KVFANEVNDH RDQIIELDQT
4460 4470 4480 4490 4500
GNQLKFLSQK QDVVLIKNLL VSVQSRWEKV VQRSIERGRS LDDARKRAKQ
4510 4520 4530 4540 4550
FHEAWKKLID WLEDAESHLD SELEISNDPD KIKLQLSKHK EFQKTLGGKQ
4560 4570 4580 4590 4600
PVYDTTIRTG RALKEKTLLA GDTQKLDNLL GEVRDKWDTV CGKSVERQHK
4610 4620 4630 4640 4650
LEEALLFSGQ FMDALQALVD WLYKVEPQLA EDQPVHGDLD LVMNLMDAHK
4660 4670 4680 4690 4700
VFQKELGKRT GTVQVLKRSG RELIEGSRDD TTWVKGQLQE LSTRWDTVCK
4710 4720 4730 4740 4750
LSVSKQSRLE QALKQAEEFR DTVHMLLEWL SEAEQTLRFR GALPDDTEAL
4760 4770 4780 4790 4800
QSLIDTHKEF MKKVEEKRVD VNTAVAMGEA ILAVCHPDCI TTIKHWITII
4810 4820 4830 4840 4850
RARFEEVLTW AKQHQQRLET ALSELVANAE LLEELLAWIQ WAETTLIQRD
4860 4870 4880 4890 4900
QEPIPQNIDR VKALITEHQS FMEEMTRKQP DVDRVTKTYK RKSVEPTHAP
4910 4920 4930 4940 4950
FMEKSRSGSR KSLNQPTPPP MPILSQSEAK NPRINQLSAR WQQVWLLALE
4960 4970 4980 4990 5000
RQRKLNDALD RLEELKEFAN FDFDVWRKKY MRWMNHKKSR VMDFFRRIDK
5010 5020 5030 5040 5050
DQDGKITRQE FIDGILASKF PTTKLEMTAV ADIFDRDGDG YIDYYEFVAA
5060 5070 5080 5090 5100
LHPNKDAYRP TTDADKIEDE VTRQVAQCKC AKRFQVEQIG ENKYRFGDSQ
5110 5120 5130 5140 5150
QLRLVRILRS TVMVRVGGGW MALDEFLVKN DPCRARGRTN IELREKFILP
5160 5170 5180 5190 5200
EGASQGMTPF RSRGRRSKPS SRAASPTRSS SSASQSNHSC TSMPSSPATP
5210 5220 5230 5240 5250
ASGTKVISSS GSKLKRPTPA FHSSRTSLAG DTSNSSSPAS TGAKANRADP
5260 5270 5280 5290 5300
KKSASRPGSR AGSRAGSRAS SRRGSDASDF DLLETQSACS DTSESSAAGG
5310 5320 5330
QGSSRRGLTK PSKIPTMSKK TTTASPRTPG PKR
Length:5,333
Mass (Da):608,239
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46E086773D81C464
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXZ0MACF1_MOUSE
Microtubule-actin cross-linking fac...
Macf1 Acf7, Aclp7, Macf
7,354Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVY8E9PVY8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQA6A0A0A0MQA6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,328Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU4B1ARU4_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA63E9QA63_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNP1E9QNP1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BF93A0A571BF93_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,323Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BGC6A0A571BGC6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q750F6Q750_MOUSE
Microtubule-actin cross-linking fac...
Macf1
4,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YKN8F6YKN8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000151346; ENSMUSP00000114568; ENSMUSG00000028649

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

3D structure databases

SMRiF7ACR9
ModBaseiSearch...

PTM databases

iPTMnetiF7ACR9

Proteomic databases

EPDiF7ACR9
jPOSTiF7ACR9
MaxQBiF7ACR9
PeptideAtlasiF7ACR9
PRIDEiF7ACR9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31853, 59 antibodies

Genome annotation databases

EnsembliENSMUST00000151346; ENSMUSP00000114568; ENSMUSG00000028649

Organism-specific databases

MGIiMGI:108559, Macf1

Phylogenomic databases

GeneTreeiENSGT00940000155824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Macf1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028649, Expressed in lung and 330 other tissues
ExpressionAtlasiF7ACR9, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR029926, Dystonin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 4 hits
PTHR23169:SF24, PTHR23169:SF24, 4 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 35 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7ACR9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7ACR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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