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UniProtKB - F6ZZX8 (F6ZZX8_HORSE)
Protein
Submitted name:
Integrin subunit alpha 4
Gene
ITGA4
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- C-X3-C chemokine binding Source: Ensembl
- integrin binding Source: GO_Central
GO - Biological processi
- cell adhesion mediated by integrin Source: GO_Central
- cell-cell adhesion Source: GO_Central
- cell-cell adhesion in response to extracellular stimulus Source: Ensembl
- cell-cell adhesion mediated by integrin Source: Ensembl
- cell-matrix adhesion Source: GO_Central
- cell-matrix adhesion involved in ameboidal cell migration Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- endodermal cell differentiation Source: Ensembl
- heterotypic cell-cell adhesion Source: Ensembl
- integrin-mediated signaling pathway Source: GO_Central
- leukocyte migration Source: GO_Central
- leukocyte tethering or rolling Source: Ensembl
- negative regulation of protein homodimerization activity Source: Ensembl
- positive regulation of endothelial cell apoptotic process Source: Ensembl
- positive regulation of vascular endothelial cell proliferation Source: Ensembl
- receptor clustering Source: Ensembl
- substrate adhesion-dependent cell spreading Source: Ensembl
Keywordsi
Molecular function | IntegrinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Cell adhesionUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Integrin subunit alpha 4Imported |
Gene namesi | Name:ITGA4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19165, ITGA4 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integrin alpha4-beta7 complex Source: Ensembl
- integrin complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 976 – 1000 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | UniRule annotationAdd BLAST | 33 | |
ChainiPRO_5018382244 | 34 – 1033 | UniRule annotationAdd BLAST | 1000 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PaxDbi | F6ZZX8 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000010500, Expressed in blood and 21 other tissues |
Interactioni
GO - Molecular functioni
- C-X3-C chemokine binding Source: Ensembl
- integrin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9796.ENSECAP00000009001 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 35 – 100 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 66 | |
Repeati | 292 – 351 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 60 | |
Repeati | 355 – 412 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 58 | |
Repeati | 416 – 478 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 463 – 861 | Integrin_alpha2InterPro annotationAdd BLAST | 399 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158443 |
HOGENOMi | CLU_004111_5_0_1 |
InParanoidi | F6ZZX8 |
TreeFami | TF105391 |
Family and domain databases
Gene3Di | 2.130.10.130, 1 hit |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits SSF69318, SSF69318, 1 hit |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 4 hits PS00242, INTEGRIN_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6ZZX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGEARRGSG PRGAAVREAV MLLLCLGVPT GRPYNLDTES ALLYEGPPNT
60 70 80 90 100
LFGYSVVLHS HGANRWLVVG APTANWLANA SVVNPGAIYR CRIGKNPDRT
110 120 130 140 150
CEQLQLGSPS GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN
160 170 180 190 200
IFYIKNENKL PTGVCYGMPS DLRAELSKRI APCYQDFVKK FGENFASCQA
210 220 230 240 250
GISSFYTEDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD KENQVKFGSY
260 270 280 290 300
LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDAKE LNILHEMKGK
310 320 330 340 350
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ SVIREEGRVF VYINSGSGAV
360 370 380 390 400
MNEMETELTG SDKYAARFGE SIVNLGDIDN DGFEDIAIGA PQEDDLRGAI
410 420 430 440 450
YIYNGRAEGI SSAFSQRIEG LQISKSLSMF GQSISGQIDA DNNGYVDVAV
460 470 480 490 500
GAFRSDSAVV LRTRPVVIVE ASLNHPESVN RTNFDCIENG LPSVCMDLKL
510 520 530 540 550
CFSYKGKEVP GYIVLFYNMS LDVNRKAESP SRFYFSSNGT SDVITGSMKV
560 570 580 590 600
SSRAANCRTH QAFMRKDVRD ILTPIQIKAA YHLGHHVISK RSTEEFPPLQ
610 620 630 640 650
PILQQKREKD VIEKTINFAR FCAHENCSAD LQLSAKIGFL KPHENKTYLA
660 670 680 690 700
VGNMKTLMLN VSLFNAGDDA YETTLHIKLP TGLYFIKILD LEEKQINCEV
710 720 730 740 750
TDSSGIVKLD CNVGYIYVDH LSRIDVSFLL DASSLSRAEE DLNITVHAAC
760 770 780 790 800
ENEGEMDDLK SNKVTLAIPL KYEVMLAVHG FVSPTSFVYG SAEENEPGTC
810 820 830 840 850
MAEKMNLTFH VINTGYSMAP NVSVEIMVPN SFIPQTNKLF NILDVQTTMG
860 870 880 890 900
ECRFENYESN CVSEQQKGAL ETLKDIFRFL SKTDKRLLYC MKADPNCLNF
910 920 930 940 950
LCNFGKMESG KEASVHVQLE GRPSILEMDE TSALKFEIRA TAFPEPNPRV
960 970 980 990 1000
IELNKDENVA HVLLEGLHHQ RPKRHFTIAI ISSSLLLGLI LLLFISYVMW
1010 1020 1030
KVGFFKRQYK SILQEENRRD SWSYVNSKSN DDD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PHJ2 | A0A5F5PHJ2_HORSE | Integrin subunit alpha 4 | ITGA4 | 997 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000011502; ENSECAP00000009001; ENSECAG00000010500 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | F6ZZX8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9796.ENSECAP00000009001 |
Proteomic databases
PaxDbi | F6ZZX8 |
Genome annotation databases
Ensembli | ENSECAT00000011502; ENSECAP00000009001; ENSECAG00000010500 |
Organism-specific databases
VGNCi | VGNC:19165, ITGA4 |
Phylogenomic databases
GeneTreei | ENSGT00940000158443 |
HOGENOMi | CLU_004111_5_0_1 |
InParanoidi | F6ZZX8 |
TreeFami | TF105391 |
Gene expression databases
Bgeei | ENSECAG00000010500, Expressed in blood and 21 other tissues |
Family and domain databases
Gene3Di | 2.130.10.130, 1 hit |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits SSF69318, SSF69318, 1 hit |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 4 hits PS00242, INTEGRIN_ALPHA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F6ZZX8_HORSE | |
Accessioni | F6ZZX8Primary (citable) accession number: F6ZZX8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | May 25, 2022 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |