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Protein

Mast/stem cell growth factor receptor

Gene
N/A
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi558MagnesiumUniRule annotation1
Binding sitei613ATPUniRule annotation1
Binding sitei782ATPUniRule annotation1
Metal bindingi783MagnesiumUniRule annotation1
Metal bindingi796MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi586 – 593ATPUniRule annotation8
Nucleotide bindingi661 – 667ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-XTR-1257604 PIP3 activates AKT signaling
R-XTR-1433557 Signaling by SCF-KIT
R-XTR-1433559 Regulation of KIT signaling
R-XTR-5673001 RAF/MAP kinase cascade
R-XTR-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mast/stem cell growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei515 – 538HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_501183623520 – 954Mast/stem cell growth factor receptorUniRule annotationAdd BLAST935

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF6ZYW4

Expressioni

Gene expression databases

BgeeiENSXETG00000021049 Expressed in 11 organ(s), highest expression level in gastrula
ExpressionAtlasiF6ZYW4 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000045513

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 299Ig-likeInterPro annotationAdd BLAST92
Domaini406 – 499Ig-likeInterPro annotationAdd BLAST94
Domaini579 – 954Protein kinaseInterPro annotationAdd BLAST376

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
InParanoidiF6ZYW4
OMAiPTFKQIV
OrthoDBiEOG091G01TL
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR027263 SCGF_receptor
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF500951 SCGF_recepter, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 5 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F6ZYW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWTYVWMLL FLLPYTGDAV PKINEGQDRF TIKVGERFQL ICRDAQLVKW
60 70 80 90 100
TFQKSGLVKK PRDVQSRPYN KSETDQILFI GKADLKHVGR YTCTNTETYE
110 120 130 140 150
NTSISLFVKD PARPFLDVPF IDVIEGSDAV GMCFPSDPDI VDIAIEKCDG
160 170 180 190 200
SPLAEDFTFT TDIEAGITIK MVQVSFDGCY VCTGNQSGTV KKSSTFSIHV
210 220 230 240 250
KPEPKKEPTI FLTKSRQLVK TGEPFEVTCT VMDVFSTVKA QWLDARDMES
260 270 280 290 300
TERANFLPTR IFSLNLTLKS DGVLFSESRT FTCQAENAIG QVNATFTLDV
310 320 330 340 350
IDVGYVNLTV LENTTISVNA GDNLVLRVYI DAYPPPDQGF WTYLNETLLN
360 370 380 390 400
TSDHYVEIRD EGNNRYVSEL HLIRLKGTEK GAYTFYTSNS DDSAFVNFNI
410 420 430 440 450
QVKTRPEILI ADRTSEGTLQ CVATGFPVPA IQWYFCPGSE QRCTDYPPIL
460 470 480 490 500
PVNEKFIQEN SSLGRVVVES TIDVNHIKKN GTVQCVASNE VESASSVFSF
510 520 530 540 550
AIKEKVRAHT LFTPLLIGFI VAAGLMCIAV AILMYKYLQK PKYEIQWKVV
560 570 580 590 600
EEINGNNYVY IDPTQLPYDN KWEFPRDRLC FGKILGAGAF GKVVEATAYG
610 620 630 640 650
LIKEDSRMTV AVKMLKPSAH STEREALMSE LKVLSYLGHH KNIVNLLGAC
660 670 680 690 700
TIGGPTLVIT EYCCYGDLLN YLRRKRDSFI CPKFEDNSEA ALYKNLLNSR
710 720 730 740 750
DMGCEGMSEY MDMKPAVSYV VPTKTDKRRS GSFGDKDVSV SIPEEDDLAL
760 770 780 790 800
DTDDLINFSY QVAQGMNFLA SKNCIHRDLA ARNILLTYGR ITKICDFGLA
810 820 830 840 850
RDIRNDSNYV VKGNARLPVK WMAPESIFHC VYTFESDVWS YGILLWEIFS
860 870 880 890 900
LGNSPYPRIP VDSKFYKMIK DGYRMMSPEC APLEMNVFRG SFFFVSLEII
910 920 930 940 950
CEEVLLSQLI FNISCSHQTS VPYPVSHVPL DHAVRINSVG SSTSSQPLLM

NSDR
Length:954
Mass (Da):107,369
Last modified:July 27, 2011 - v1
Checksum:iA843F6543F87F1BA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AWH8F7AWH8_XENTR
KIT proto-oncogene receptor tyrosin...
920Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01036219 Genomic DNA No translation available.
AAMC01036220 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000045513; ENSXETP00000045513; ENSXETG00000021049

Similar proteinsi

Entry informationi

Entry nameiF6ZYW4_XENTR
AccessioniPrimary (citable) accession number: F6ZYW4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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