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Entry version 48 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein

HECT-type E3 ubiquitin transferase

Gene

HUWE1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4310Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairARBA annotation, Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HUWE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:18916, HUWE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1299 – 1338UBAInterPro annotationAdd BLAST40
Domaini1586 – 1663WWEInterPro annotationAdd BLAST78
Domaini4007 – 4343HECTInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni748 – 801DisorderedSequence analysisAdd BLAST54
Regioni961 – 1021DisorderedSequence analysisAdd BLAST61
Regioni1274 – 1303DisorderedSequence analysisAdd BLAST30
Regioni1379 – 1398DisorderedSequence analysisAdd BLAST20
Regioni2001 – 2048DisorderedSequence analysisAdd BLAST48
Regioni2245 – 2325DisorderedSequence analysisAdd BLAST81
Regioni2339 – 2462DisorderedSequence analysisAdd BLAST124
Regioni2677 – 2953DisorderedSequence analysisAdd BLAST277
Regioni3019 – 3042DisorderedSequence analysisAdd BLAST24
Regioni3224 – 3250DisorderedSequence analysisAdd BLAST27
Regioni3337 – 3364DisorderedSequence analysisAdd BLAST28
Regioni3388 – 3408DisorderedSequence analysisAdd BLAST21
Regioni3454 – 3493DisorderedSequence analysisAdd BLAST40
Regioni3522 – 3550DisorderedSequence analysisAdd BLAST29
Regioni3721 – 3742DisorderedSequence analysisAdd BLAST22
Regioni3763 – 3817DisorderedSequence analysisAdd BLAST55
Regioni3863 – 3903DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3073 – 3093Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi779 – 798PolarSequence analysisAdd BLAST20
Compositional biasi970 – 987PolarSequence analysisAdd BLAST18
Compositional biasi1274 – 1293PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2001 – 2018PolarSequence analysisAdd BLAST18
Compositional biasi2019 – 2043PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2245 – 2278PolarSequence analysisAdd BLAST34
Compositional biasi2367 – 2385PolarSequence analysisAdd BLAST19
Compositional biasi2389 – 2454AcidicSequence analysisAdd BLAST66
Compositional biasi2677 – 2701PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2702 – 2751PolarSequence analysisAdd BLAST50
Compositional biasi2752 – 2766Pro-richSequence analysisAdd BLAST15
Compositional biasi2798 – 2874PolarSequence analysisAdd BLAST77
Compositional biasi2901 – 2917PolarSequence analysisAdd BLAST17
Compositional biasi3024 – 3042PolarSequence analysisAdd BLAST19
Compositional biasi3227 – 3243PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3522 – 3539PolarSequence analysisAdd BLAST18
Compositional biasi3782 – 3798PolarSequence analysisAdd BLAST17
Compositional biasi3863 – 3880PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156319

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F6ZJZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE
60 70 80 90 100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT
110 120 130 140 150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR
160 170 180 190 200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF
210 220 230 240 250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP
260 270 280 290 300
KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI
310 320 330 340 350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT
360 370 380 390 400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG
410 420 430 440 450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH
460 470 480 490 500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPSTTQEGEE METDMDVADV
510 520 530 540 550
TMESSSGLSI SMEHRLDVEL RAGPSSSTSI SSGPGPRPGV QCIPQRAALL
560 570 580 590 600
KSMLNFLKKA IQDPAFSDGI RHVMDGSLPT SLKHIISNAE YYGPSLFLLA
610 620 630 640 650
TEVVTVFVFQ EPSLLSSLQD NGLTDVMLHA LLIKDVPATR EVLGSLPNVF
660 670 680 690 700
SALCLNARGL QSFVQCQPFE RLFKVLLSPD YLPAMRRRRS SDPLGDTASN
710 720 730 740 750
LGSAVDELMR HQPTLKTDAT TAIIKLLEEI CNLGRDPKYI CQKPSIQKAD
760 770 780 790 800
GTATAPPPRS NHAAEEASSE DEEEEEVQAM QSFNSAQQNE TEPNQQVVGT
810 820 830 840 850
EERIPIPLMD YILNVTLSHE PKVLQEGLLQ LDSILSSLEP LHRPIESPGG
860 870 880 890 900
SVLLRELACA GNVADATLSA QATPLLHALT AAHAYIMMFV HTCRVGQSEI
910 920 930 940 950
RSISVNQWGS QLGLSVLSKL SQLYCSLVWE STVLLSLCTP NSLPSGCEFG
960 970 980 990 1000
QADMQKLVPK DEKAGTTQGG KRSDGEQDGT AGSMDASTQG LLEGIGLDGD
1010 1020 1030 1040 1050
TLAPMETDEP TTSDSKGKSK ITPAMAARIK QIKPLLSASS RLGRALAELF
1060 1070 1080 1090 1100
GLLVKLCVGS PVRQRRSHHA ASTTTAPTPA ARSTASALTK LLTKGLSWQP
1110 1120 1130 1140 1150
PPYTPTPRFR LTFFICSVGF TSPMLFDERK YPYHLMLQKF LCSGGHNALF
1160 1170 1180 1190 1200
ETFNWALSMG GKVPVAEGLE HSELPDGTGE FLDAWLMLVE KMVNPTTVLE
1210 1220 1230 1240 1250
SPHSLPAKLP GGVQNFPQFS ALRFLVVTQK AAFTCIKNLW NRKPLKVYGG
1260 1270 1280 1290 1300
RMAESMLAIL CHILRGEPVI RERLSKEKEG SRGEEDTGQE EGGSRREPQV
1310 1320 1330 1340 1350
NQQQLQQLMD MGFTREHAME ALLNTSTMEQ ATEYLLTHPP PIMGGVVRDL
1360 1370 1380 1390 1400
SMSEEDQMMR AIAMSLGQDI PMDQRAESPE EVACRKEEEE RKAREKQEEE
1410 1420 1430 1440 1450
EAKCLEKFQD ADPLEQDELH TFTDTMLPGC FHLLDELPDT VYRVCDLIMT
1460 1470 1480 1490 1500
AIKRNGADYR DMILKQVVNQ VWEAADVLIK AALPLTTSDT KTVSEWISQM
1510 1520 1530 1540 1550
ATLPQASNLA TRILLLTLLF EELKLPCAWV VESSGILNVL IKLLEVVQPC
1560 1570 1580 1590 1600
LQAAKEQKEV QTPKWITPVL LLIDFYEKTA ISSKRRAQMT KYLQSNNNNW
1610 1620 1630 1640 1650
RWFDDRSGRW CSYSASNNST IDSAWKSGET SVRFTAGRRR YTVQFTTMVQ
1660 1670 1680 1690 1700
VNEETGNRRP VMLTLLRVPR LNKNSKNSNG QELEKTLEES KEMDIKRKEN
1710 1720 1730 1740 1750
KANDTPLALE STNIEKETSL EETKIGEILI QGLTEDMVTV LIRACVSMLG
1760 1770 1780 1790 1800
VPVDPDTLHA TLRLCLRLTR DHKYAMMFAE LKSTRMILNL TQSSGFNGFT
1810 1820 1830 1840 1850
PLVTLLLRHI IEDPCTLRHT MEKVVRSAAT SGAGSTTSGV VSGSLGSREI
1860 1870 1880 1890 1900
NYILRVLGPA ACRNPDIFTE VANCCIRIAL PAPRGSGTAS DDEFENLRIK
1910 1920 1930 1940 1950
GPNAVQLVKT TPLKPSPLPV IPDTIKEVIY DMLNALAAYH APEEADKSDP
1960 1970 1980 1990 2000
KPGGMTQEVG QLLQDMGDDV YQQYRSLTRQ SSDFDTQSGF SLNSQVFAAD
2010 2020 2030 2040 2050
GTSTETSTSG ATQGEASTPE ESRDGKKDKE GDRASEEGKQ KGKGSKPLMP
2060 2070 2080 2090 2100
TSTILRLLAE LVRSYVGIAT LIANYSYTVG QSELIKEDCS VLAFVLDHLL
2110 2120 2130 2140 2150
PHTQNAEDKD TPALARLFLA SLAAAGSGTD AQVALVNEVK AALGRALAMA
2160 2170 2180 2190 2200
ESTEKHARLQ AVMCIISTIM ESCPSTSSFY SSATAKTQHN GMNNIIRLFL
2210 2220 2230 2240 2250
KKGLVNDLAR VPHSLDLSSP NMANTVNAAL KPLETLSRIV NQPSSLFGSK
2260 2270 2280 2290 2300
SASSKSKSEQ DAQGASQDSN SNQQDPGEPG EAEVQEEDHD VTQTEVADGD
2310 2320 2330 2340 2350
IMDGEAETDS VVIAGQPEVL SSQEMQVENE LEDLIDELLE RDGGSGNSTI
2360 2370 2380 2390 2400
IVSRSGEDES QEDVLMDEAP SNLSQASTLQ ANREDSMNIL DPEDEEEHTQ
2410 2420 2430 2440 2450
EEDSSGSNED EDDSQDEEEE EEEDEEDDQE DDEGEEGDED DDDDGSEMEL
2460 2470 2480 2490 2500
DEDYPDMNAS PLVRFERFDR EDDLIIEFDN MFSSATDIPP SPGNIPTTHP
2510 2520 2530 2540 2550
LMVRHADHSS LTLGSGSSTT RLTQGIGRSQ RTLRQLTANT GHTIHVHYPG
2560 2570 2580 2590 2600
NRQPNPPLIL QRLLGPSAAA DILQLSSSLP LQSRGRARLL VGNDDVHIIA
2610 2620 2630 2640 2650
RSDDELLDDF FHDQSTATSQ AGTLSSIPTA LTRWTEECKV LDAESMHDCV
2660 2670 2680 2690 2700
SVVKVPIVNH LEFLRDEELE ERREKRRKQL AEEETKITDK GKEDKENRDQ
2710 2720 2730 2740 2750
SAQCTASKTN DSTEQNLSDG TPMPDSYPTT PSSTDAATSE PKETLVTLQP
2760 2770 2780 2790 2800
SQQPPTLPPP PALGEIPQEL QSPAGERGSS TQLLMPVEPE ELGPTRPSGE
2810 2820 2830 2840 2850
AETTQMELSP APTITSLSPE RAEDSDALTA VSSQLEGSPM DTSSLASCTL
2860 2870 2880 2890 2900
EEAVGDTSAA GSSEQPTAGS STPGDAPPVV TELQGGGDES GEPAQPPEDS
2910 2920 2930 2940 2950
SPPASSESSS TRDSAVAISG ADSRGILEEP LPSTSSEEED PLAGISLPEG
2960 2970 2980 2990 3000
VDPSFLAALP DDIRREVLQN QLGIRPPTRT APSTNSSAPA VVGNPGVTEV
3010 3020 3030 3040 3050
SPEFLAALPP AIQEEVLAQQ RAEQQRRELA QNASSDTPMD PVTFIQTLPS
3060 3070 3080 3090 3100
DLRRSVLEDM EDSVLAVMPP DIAAEAQALR REQEARQRQL MHERLFGHSS
3110 3120 3130 3140 3150
TSALSAILRS PAFTSRLSGN RGVQYTRLAV QRGGTFQMGG SSSHNRPSGS
3160 3170 3180 3190 3200
NVDTLLRLRG RLLLDHEALS CLLVLLFVDE PKLNTSRLHR VLRNLCYHAQ
3210 3220 3230 3240 3250
TRHWVIRSLL SILQRSSESE LCIETPKLSS SEEKGKKSSK SCGSSSHENR
3260 3270 3280 3290 3300
PLDLLHKMES KSSNQLSWLS VSMDAALGCR TNIFQIQRSG GRKHTEKHAS
3310 3320 3330 3340 3350
SGSTVHIHPQ AAPVVCRHVL DTLIQLAKVF PSHFTQQRTK ETNCESDRER
3360 3370 3380 3390 3400
GSKQTCSPCS SQPNSSGICT DFWDLLVKLD NMNVSRKGKN SVKSVPVSAS
3410 3420 3430 3440 3450
GEGETSPYSL EASPLGQLMN MLSHPVIRRS SLLTEKLLRL LSLISIALPE
3460 3470 3480 3490 3500
NKVSEAQTNS GSSASSTTVT TSTTSTTTTT AASSTPTPAT ATTPVTSAPA
3510 3520 3530 3540 3550
LVAATAISTI AVAASTTVTT PTTATTTVST CTTTKASKSP AKVGDGGSSS
3560 3570 3580 3590 3600
ADFKMVSSGL TENQLQLSVE VLTSHSCSEE GLEDAANVLL QLSRGDSGTR
3610 3620 3630 3640 3650
DTVLKLLLNG ARHLGYTLCK QIGTLLAELR EYNLEQQRRA QCETLSPDGL
3660 3670 3680 3690 3700
PEEQPQTTKL KGKMQSRFDM AENVVIVASQ KRPLGGRELQ LPSMSMLTSK
3710 3720 3730 3740 3750
TSTQKFFLRV LQVIIQLRDD TRRANKKAKQ TGRLGSSGLG SASSIQAAVR
3760 3770 3780 3790 3800
QLEAEADAII QMSESSQSEA SVRREESPMD VDQPSPSAQD TQSIGSDGAL
3810 3820 3830 3840 3850
QGEKEKEERP PELPLLSEQL SLDELWDMLG ECLKELEESH DQHAVLVLQP
3860 3870 3880 3890 3900
AVEAFFLVHA TERESKPPVR DTRESQLAHI KDEPPPLSPA PLTPATPSSL
3910 3920 3930 3940 3950
DPFFSREPSS MHISSSLPPD TQKFLRFAET HRTVLNQILR QSTTHLADGP
3960 3970 3980 3990 4000
FAVLVDYIRV LDFDVKRKYF RQELERLDEG LRKEDMAVHV RRDHVFEDSY
4010 4020 4030 4040 4050
RELHRKSPEE MKNRLYIVFE GEEGQDAGGL LREWYMIISR EMFNPMYALF
4060 4070 4080 4090 4100
RTSPGDRVTY TINPSSHCNP NHLSYFKFVG RIVAKAVYDN RLLECYFTRS
4110 4120 4130 4140 4150
FYKHILGKSV RYTDMESEDY HFYQGLVYLL ENDVSTLGYD LTFSTEVQEF
4160 4170 4180 4190 4200
GVCEVRDLKP NGANILVTEE NKKEYVHLVC QMRMTGAIRK QLAAFLEGFY
4210 4220 4230 4240 4250
EIIPKRLISI FTEQELELLI SGLPTIDIDD LKSNTEYHKY QSNSIQIQWF
4260 4270 4280 4290 4300
WRALRSFDQA DRAKFLQFVT GTSKVPLQGF AALEGMNGIQ KFQIHRDDRS
4310 4320 4330 4340
TDRLPSAHTC FNQLDLPAYE SFEKLRHMLL LAIQECSEGF GLA
Length:4,343
Mass (Da):478,472
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C234E18B48C394D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HWQ7A0A3Q2HWQ7_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,417Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UR14F6UR14_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H4T8A0A3Q2H4T8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HF72A0A3Q2HF72_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L3C6A0A3Q2L3C6_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PKP8A0A5F5PKP8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PN32A0A5F5PN32_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSECAT00000024109; ENSECAP00000020012; ENSECAG00000021385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000024109; ENSECAP00000020012; ENSECAG00000021385

Organism-specific databases

VGNCiVGNC:18916, HUWE1

Phylogenomic databases

GeneTreeiENSGT00940000156319

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZJZ7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZJZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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