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UniProtKB - F6ZJZ7 (F6ZJZ7_HORSE)

Entry version 48 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
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Protein

HECT-type E3 ubiquitin transferase

Gene

HUWE1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4310Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairARBA annotation, Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HUWE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:18916, HUWE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1299 – 1338UBAInterPro annotationAdd BLAST40
Domaini1586 – 1663WWEInterPro annotationAdd BLAST78
Domaini4007 – 4343HECTInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni748 – 801DisorderedSequence analysisAdd BLAST54
Regioni961 – 1021DisorderedSequence analysisAdd BLAST61
Regioni1274 – 1303DisorderedSequence analysisAdd BLAST30
Regioni1379 – 1398DisorderedSequence analysisAdd BLAST20
Regioni2001 – 2048DisorderedSequence analysisAdd BLAST48
Regioni2245 – 2325DisorderedSequence analysisAdd BLAST81
Regioni2339 – 2462DisorderedSequence analysisAdd BLAST124
Regioni2677 – 2953DisorderedSequence analysisAdd BLAST277
Regioni3019 – 3042DisorderedSequence analysisAdd BLAST24
Regioni3224 – 3250DisorderedSequence analysisAdd BLAST27
Regioni3337 – 3364DisorderedSequence analysisAdd BLAST28
Regioni3388 – 3408DisorderedSequence analysisAdd BLAST21
Regioni3454 – 3493DisorderedSequence analysisAdd BLAST40
Regioni3522 – 3550DisorderedSequence analysisAdd BLAST29
Regioni3721 – 3742DisorderedSequence analysisAdd BLAST22
Regioni3763 – 3817DisorderedSequence analysisAdd BLAST55
Regioni3863 – 3903DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3073 – 3093Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi779 – 798PolarSequence analysisAdd BLAST20
Compositional biasi970 – 987PolarSequence analysisAdd BLAST18
Compositional biasi1274 – 1293PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2001 – 2018PolarSequence analysisAdd BLAST18
Compositional biasi2019 – 2043PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2245 – 2278PolarSequence analysisAdd BLAST34
Compositional biasi2367 – 2385PolarSequence analysisAdd BLAST19
Compositional biasi2389 – 2454AcidicSequence analysisAdd BLAST66
Compositional biasi2677 – 2701PolyampholyteSequence analysisAdd BLAST25
Compositional biasi2702 – 2751PolarSequence analysisAdd BLAST50
Compositional biasi2752 – 2766Pro-richSequence analysisAdd BLAST15
Compositional biasi2798 – 2874PolarSequence analysisAdd BLAST77
Compositional biasi2901 – 2917PolarSequence analysisAdd BLAST17
Compositional biasi3024 – 3042PolarSequence analysisAdd BLAST19
Compositional biasi3227 – 3243PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3522 – 3539PolarSequence analysisAdd BLAST18
Compositional biasi3782 – 3798PolarSequence analysisAdd BLAST17
Compositional biasi3863 – 3880PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156319

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F6ZJZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE 
        60         70         80         90        100
LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT 
       110        120        130        140        150
ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR 
       160        170        180        190        200
LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF 
       210        220        230        240        250
EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP 
       260        270        280        290        300
KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 
       310        320        330        340        350
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT 
       360        370        380        390        400
GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG 
       410        420        430        440        450
EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH 
       460        470        480        490        500
SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPSTTQEGEE METDMDVADV 
       510        520        530        540        550
TMESSSGLSI SMEHRLDVEL RAGPSSSTSI SSGPGPRPGV QCIPQRAALL 
       560        570        580        590        600
KSMLNFLKKA IQDPAFSDGI RHVMDGSLPT SLKHIISNAE YYGPSLFLLA 
       610        620        630        640        650
TEVVTVFVFQ EPSLLSSLQD NGLTDVMLHA LLIKDVPATR EVLGSLPNVF 
       660        670        680        690        700
SALCLNARGL QSFVQCQPFE RLFKVLLSPD YLPAMRRRRS SDPLGDTASN 
       710        720        730        740        750
LGSAVDELMR HQPTLKTDAT TAIIKLLEEI CNLGRDPKYI CQKPSIQKAD 
       760        770        780        790        800
GTATAPPPRS NHAAEEASSE DEEEEEVQAM QSFNSAQQNE TEPNQQVVGT 
       810        820        830        840        850
EERIPIPLMD YILNVTLSHE PKVLQEGLLQ LDSILSSLEP LHRPIESPGG 
       860        870        880        890        900
SVLLRELACA GNVADATLSA QATPLLHALT AAHAYIMMFV HTCRVGQSEI 
       910        920        930        940        950
RSISVNQWGS QLGLSVLSKL SQLYCSLVWE STVLLSLCTP NSLPSGCEFG 
       960        970        980        990       1000
QADMQKLVPK DEKAGTTQGG KRSDGEQDGT AGSMDASTQG LLEGIGLDGD 
      1010       1020       1030       1040       1050
TLAPMETDEP TTSDSKGKSK ITPAMAARIK QIKPLLSASS RLGRALAELF 
      1060       1070       1080       1090       1100
GLLVKLCVGS PVRQRRSHHA ASTTTAPTPA ARSTASALTK LLTKGLSWQP 
      1110       1120       1130       1140       1150
PPYTPTPRFR LTFFICSVGF TSPMLFDERK YPYHLMLQKF LCSGGHNALF 
      1160       1170       1180       1190       1200
ETFNWALSMG GKVPVAEGLE HSELPDGTGE FLDAWLMLVE KMVNPTTVLE 
      1210       1220       1230       1240       1250
SPHSLPAKLP GGVQNFPQFS ALRFLVVTQK AAFTCIKNLW NRKPLKVYGG 
      1260       1270       1280       1290       1300
RMAESMLAIL CHILRGEPVI RERLSKEKEG SRGEEDTGQE EGGSRREPQV 
      1310       1320       1330       1340       1350
NQQQLQQLMD MGFTREHAME ALLNTSTMEQ ATEYLLTHPP PIMGGVVRDL 
      1360       1370       1380       1390       1400
SMSEEDQMMR AIAMSLGQDI PMDQRAESPE EVACRKEEEE RKAREKQEEE 
      1410       1420       1430       1440       1450
EAKCLEKFQD ADPLEQDELH TFTDTMLPGC FHLLDELPDT VYRVCDLIMT 
      1460       1470       1480       1490       1500
AIKRNGADYR DMILKQVVNQ VWEAADVLIK AALPLTTSDT KTVSEWISQM 
      1510       1520       1530       1540       1550
ATLPQASNLA TRILLLTLLF EELKLPCAWV VESSGILNVL IKLLEVVQPC 
      1560       1570       1580       1590       1600
LQAAKEQKEV QTPKWITPVL LLIDFYEKTA ISSKRRAQMT KYLQSNNNNW 
      1610       1620       1630       1640       1650
RWFDDRSGRW CSYSASNNST IDSAWKSGET SVRFTAGRRR YTVQFTTMVQ 
      1660       1670       1680       1690       1700
VNEETGNRRP VMLTLLRVPR LNKNSKNSNG QELEKTLEES KEMDIKRKEN 
      1710       1720       1730       1740       1750
KANDTPLALE STNIEKETSL EETKIGEILI QGLTEDMVTV LIRACVSMLG 
      1760       1770       1780       1790       1800
VPVDPDTLHA TLRLCLRLTR DHKYAMMFAE LKSTRMILNL TQSSGFNGFT 
      1810       1820       1830       1840       1850
PLVTLLLRHI IEDPCTLRHT MEKVVRSAAT SGAGSTTSGV VSGSLGSREI 
      1860       1870       1880       1890       1900
NYILRVLGPA ACRNPDIFTE VANCCIRIAL PAPRGSGTAS DDEFENLRIK 
      1910       1920       1930       1940       1950
GPNAVQLVKT TPLKPSPLPV IPDTIKEVIY DMLNALAAYH APEEADKSDP 
      1960       1970       1980       1990       2000
KPGGMTQEVG QLLQDMGDDV YQQYRSLTRQ SSDFDTQSGF SLNSQVFAAD 
      2010       2020       2030       2040       2050
GTSTETSTSG ATQGEASTPE ESRDGKKDKE GDRASEEGKQ KGKGSKPLMP 
      2060       2070       2080       2090       2100
TSTILRLLAE LVRSYVGIAT LIANYSYTVG QSELIKEDCS VLAFVLDHLL 
      2110       2120       2130       2140       2150
PHTQNAEDKD TPALARLFLA SLAAAGSGTD AQVALVNEVK AALGRALAMA 
      2160       2170       2180       2190       2200
ESTEKHARLQ AVMCIISTIM ESCPSTSSFY SSATAKTQHN GMNNIIRLFL 
      2210       2220       2230       2240       2250
KKGLVNDLAR VPHSLDLSSP NMANTVNAAL KPLETLSRIV NQPSSLFGSK 
      2260       2270       2280       2290       2300
SASSKSKSEQ DAQGASQDSN SNQQDPGEPG EAEVQEEDHD VTQTEVADGD 
      2310       2320       2330       2340       2350
IMDGEAETDS VVIAGQPEVL SSQEMQVENE LEDLIDELLE RDGGSGNSTI 
      2360       2370       2380       2390       2400
IVSRSGEDES QEDVLMDEAP SNLSQASTLQ ANREDSMNIL DPEDEEEHTQ 
      2410       2420       2430       2440       2450
EEDSSGSNED EDDSQDEEEE EEEDEEDDQE DDEGEEGDED DDDDGSEMEL 
      2460       2470       2480       2490       2500
DEDYPDMNAS PLVRFERFDR EDDLIIEFDN MFSSATDIPP SPGNIPTTHP 
      2510       2520       2530       2540       2550
LMVRHADHSS LTLGSGSSTT RLTQGIGRSQ RTLRQLTANT GHTIHVHYPG 
      2560       2570       2580       2590       2600
NRQPNPPLIL QRLLGPSAAA DILQLSSSLP LQSRGRARLL VGNDDVHIIA 
      2610       2620       2630       2640       2650
RSDDELLDDF FHDQSTATSQ AGTLSSIPTA LTRWTEECKV LDAESMHDCV 
      2660       2670       2680       2690       2700
SVVKVPIVNH LEFLRDEELE ERREKRRKQL AEEETKITDK GKEDKENRDQ 
      2710       2720       2730       2740       2750
SAQCTASKTN DSTEQNLSDG TPMPDSYPTT PSSTDAATSE PKETLVTLQP 
      2760       2770       2780       2790       2800
SQQPPTLPPP PALGEIPQEL QSPAGERGSS TQLLMPVEPE ELGPTRPSGE 
      2810       2820       2830       2840       2850
AETTQMELSP APTITSLSPE RAEDSDALTA VSSQLEGSPM DTSSLASCTL 
      2860       2870       2880       2890       2900
EEAVGDTSAA GSSEQPTAGS STPGDAPPVV TELQGGGDES GEPAQPPEDS 
      2910       2920       2930       2940       2950
SPPASSESSS TRDSAVAISG ADSRGILEEP LPSTSSEEED PLAGISLPEG 
      2960       2970       2980       2990       3000
VDPSFLAALP DDIRREVLQN QLGIRPPTRT APSTNSSAPA VVGNPGVTEV 
      3010       3020       3030       3040       3050
SPEFLAALPP AIQEEVLAQQ RAEQQRRELA QNASSDTPMD PVTFIQTLPS 
      3060       3070       3080       3090       3100
DLRRSVLEDM EDSVLAVMPP DIAAEAQALR REQEARQRQL MHERLFGHSS 
      3110       3120       3130       3140       3150
TSALSAILRS PAFTSRLSGN RGVQYTRLAV QRGGTFQMGG SSSHNRPSGS 
      3160       3170       3180       3190       3200
NVDTLLRLRG RLLLDHEALS CLLVLLFVDE PKLNTSRLHR VLRNLCYHAQ 
      3210       3220       3230       3240       3250
TRHWVIRSLL SILQRSSESE LCIETPKLSS SEEKGKKSSK SCGSSSHENR 
      3260       3270       3280       3290       3300
PLDLLHKMES KSSNQLSWLS VSMDAALGCR TNIFQIQRSG GRKHTEKHAS 
      3310       3320       3330       3340       3350
SGSTVHIHPQ AAPVVCRHVL DTLIQLAKVF PSHFTQQRTK ETNCESDRER 
      3360       3370       3380       3390       3400
GSKQTCSPCS SQPNSSGICT DFWDLLVKLD NMNVSRKGKN SVKSVPVSAS 
      3410       3420       3430       3440       3450
GEGETSPYSL EASPLGQLMN MLSHPVIRRS SLLTEKLLRL LSLISIALPE 
      3460       3470       3480       3490       3500
NKVSEAQTNS GSSASSTTVT TSTTSTTTTT AASSTPTPAT ATTPVTSAPA 
      3510       3520       3530       3540       3550
LVAATAISTI AVAASTTVTT PTTATTTVST CTTTKASKSP AKVGDGGSSS 
      3560       3570       3580       3590       3600
ADFKMVSSGL TENQLQLSVE VLTSHSCSEE GLEDAANVLL QLSRGDSGTR 
      3610       3620       3630       3640       3650
DTVLKLLLNG ARHLGYTLCK QIGTLLAELR EYNLEQQRRA QCETLSPDGL 
      3660       3670       3680       3690       3700
PEEQPQTTKL KGKMQSRFDM AENVVIVASQ KRPLGGRELQ LPSMSMLTSK 
      3710       3720       3730       3740       3750
TSTQKFFLRV LQVIIQLRDD TRRANKKAKQ TGRLGSSGLG SASSIQAAVR 
      3760       3770       3780       3790       3800
QLEAEADAII QMSESSQSEA SVRREESPMD VDQPSPSAQD TQSIGSDGAL 
      3810       3820       3830       3840       3850
QGEKEKEERP PELPLLSEQL SLDELWDMLG ECLKELEESH DQHAVLVLQP 
      3860       3870       3880       3890       3900
AVEAFFLVHA TERESKPPVR DTRESQLAHI KDEPPPLSPA PLTPATPSSL 
      3910       3920       3930       3940       3950
DPFFSREPSS MHISSSLPPD TQKFLRFAET HRTVLNQILR QSTTHLADGP 
      3960       3970       3980       3990       4000
FAVLVDYIRV LDFDVKRKYF RQELERLDEG LRKEDMAVHV RRDHVFEDSY 
      4010       4020       4030       4040       4050
RELHRKSPEE MKNRLYIVFE GEEGQDAGGL LREWYMIISR EMFNPMYALF 
      4060       4070       4080       4090       4100
RTSPGDRVTY TINPSSHCNP NHLSYFKFVG RIVAKAVYDN RLLECYFTRS 
      4110       4120       4130       4140       4150
FYKHILGKSV RYTDMESEDY HFYQGLVYLL ENDVSTLGYD LTFSTEVQEF 
      4160       4170       4180       4190       4200
GVCEVRDLKP NGANILVTEE NKKEYVHLVC QMRMTGAIRK QLAAFLEGFY 
      4210       4220       4230       4240       4250
EIIPKRLISI FTEQELELLI SGLPTIDIDD LKSNTEYHKY QSNSIQIQWF 
      4260       4270       4280       4290       4300
WRALRSFDQA DRAKFLQFVT GTSKVPLQGF AALEGMNGIQ KFQIHRDDRS 
      4310       4320       4330       4340 
TDRLPSAHTC FNQLDLPAYE SFEKLRHMLL LAIQECSEGF GLA
Length:4,343
Mass (Da):478,472
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C234E18B48C394D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HWQ7A0A3Q2HWQ7_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,417Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UR14F6UR14_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H4T8A0A3Q2H4T8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HF72A0A3Q2HF72_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L3C6A0A3Q2L3C6_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PKP8A0A5F5PKP8_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PN32A0A5F5PN32_HORSE
HECT-type E3 ubiquitin transferase
HUWE1
4,261Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000024109; ENSECAP00000020012; ENSECAG00000021385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000024109; ENSECAP00000020012; ENSECAG00000021385

Organism-specific databases

VGNCiVGNC:18916, HUWE1

Phylogenomic databases

GeneTreeiENSGT00940000156319

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSECAG00000021385, Expressed in trophectoderm and 22 other tissues

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd14288, UBA_HUWE1, 1 hit
Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
IPR015940, UBA
IPR009060, UBA-like_sf
IPR041918, UBA_HUWE1
IPR004170, WWE-dom
IPR037197, WWE_dom_sf
PfamiView protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF00627, UBA, 1 hit
PF14377, UBM, 3 hits
PF02825, WWE, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF117839, SSF117839, 1 hit
SSF46934, SSF46934, 1 hit
SSF48371, SSF48371, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS50030, UBA, 1 hit
PS50918, WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZJZ7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZJZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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