UniProtKB - F6ZJP9 (F6ZJP9_HORSE)
Protein
Submitted name:
Lecithin-cholesterol acyltransferase
Gene
LCAT
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: Ensembl
- apolipoprotein A-I binding Source: Ensembl
- phosphatidylcholine-sterol O-acyltransferase activity Source: GO_Central
- platelet-activating factor acetyltransferase activity Source: Ensembl
- triglyceride lipase activity Source: GO_Central
GO - Biological processi
- cholesterol esterification Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- cholesterol metabolic process Source: Ensembl
- high-density lipoprotein particle remodeling Source: Ensembl
- lipid metabolic process Source: GO_Central
- lipoprotein biosynthetic process Source: Ensembl
- phosphatidylcholine biosynthetic process Source: Ensembl
- regulation of high-density lipoprotein particle assembly Source: Ensembl
- reverse cholesterol transport Source: Ensembl
- very-low-density lipoprotein particle remodeling Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Lecithin-cholesterol acyltransferaseImported |
Gene namesi | Name:LCATImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19606, LCAT |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
- high-density lipoprotein particle Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 199 – 216 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5003346889 | 25 – 440 | Sequence analysisAdd BLAST | 416 |
Proteomic databases
PaxDbi | F6ZJP9 |
PRIDEi | F6ZJP9 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022392, Expressed in liver and 23 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000160052 |
HOGENOMi | CLU_037070_1_0_1 |
InParanoidi | F6ZJP9 |
OMAi | WEDTKNL |
OrthoDBi | 828056at2759 |
TreeFami | TF313258 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR003386, LACT/PDAT_acylTrfase |
Pfami | View protein in Pfam PF02450, LCAT, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
F6ZJP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPPGSPWQW VLLLLGLLLP SAAPFWLLNV LFPPHTTPKA ELSNHTRPVI
60 70 80 90 100
LVPGCLGNQL EAKLDKPDVV NWMCYRKTED FFTIWLDLNM FLPLGVDCWI
110 120 130 140 150
DNTRVVYNRS SGRVSNAPGV QIRVPGFGKT YSVEYLDTSK LAGYMHTLVQ
160 170 180 190 200
NLVNNGYVRD ETVRAAPYDW RLEPSQQEEY YGKLAGLVEE MHATYGKPVF
210 220 230 240 250
LIGHSLGCLH LLYFLLRQPQ SWKDRFIDGF ISLGAPWGGS IKPMLVLASG
260 270 280 290 300
DNQGIPIMSS IKLKEEQRMT TTSPWMFPSS RAWPEDHVFI STPSFNYTGR
310 320 330 340 350
DFQRFFTDLH FEEGWYMWLQ SRDLLAGLPA PGVEVYCLYG VGLPTPSTYI
360 370 380 390 400
FDHGFPYTDP VGVLYEDGDD TVATRSTELC ARWQGRQPQP VHLLPLHGIQ
410 420 430 440
HLNMVFSNQT LEHVNAILLG TYRRSSPASP AASREPLPPE
Sequence databases
RefSeqi | XP_001498513.1, XM_001498463.4 |
Genome annotation databases
Ensembli | ENSECAT00000024123; ENSECAP00000020026; ENSECAG00000022392 |
GeneIDi | 100053753 |
KEGGi | ecb:100053753 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001498513.1, XM_001498463.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6ZJP9 |
PRIDEi | F6ZJP9 |
Genome annotation databases
Ensembli | ENSECAT00000024123; ENSECAP00000020026; ENSECAG00000022392 |
GeneIDi | 100053753 |
KEGGi | ecb:100053753 |
Organism-specific databases
CTDi | 3931 |
VGNCi | VGNC:19606, LCAT |
Phylogenomic databases
GeneTreei | ENSGT00940000160052 |
HOGENOMi | CLU_037070_1_0_1 |
InParanoidi | F6ZJP9 |
OMAi | WEDTKNL |
OrthoDBi | 828056at2759 |
TreeFami | TF313258 |
Gene expression databases
Bgeei | ENSECAG00000022392, Expressed in liver and 23 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR003386, LACT/PDAT_acylTrfase |
Pfami | View protein in Pfam PF02450, LCAT, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6ZJP9_HORSE | |
Accessioni | F6ZJP9Primary (citable) accession number: F6ZJP9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |