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UniProtKB - F6ZHP7 (F6ZHP7_HORSE)

Entry version 50 (02 Dec 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Myosin binding protein C3

Gene

MYBPC3

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin binding protein C3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYBPC3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:59276, MYBPC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6ZHP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000024318, Expressed in multi-cellular organism and 16 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 242Ig-likeInterPro annotationAdd BLAST109
Domaini347 – 425Ig-likeInterPro annotationAdd BLAST79
Domaini439 – 512Ig-likeInterPro annotationAdd BLAST74
Domaini632 – 752Ig-likeInterPro annotationAdd BLAST121
Domaini761 – 857Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini859 – 954Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini958 – 1046Ig-likeInterPro annotationAdd BLAST89
Domaini1055 – 1150Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1168 – 1256Ig-likeInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni97 – 142DisorderedSequence analysisAdd BLAST46

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Immunoglobulin domainARBA annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006405_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6ZHP7

TreeFam database of animal gene trees

More...TreeFami		TF334735

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR040849, MyBP-C_THB

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 8 hits
PF18362, THB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 8 hits
SM00408, IGc2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 8 hits
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6ZHP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEPGKKPVS AFSKKPRSAE VAAGSPAVFE AETERAGLKV RWQRAGSDIS 
        60         70         80         90        100
ASDKYGLAAE GTRHTLTVRD VGPADQGSYA VIAGSSKVKF DLKVIEPEKT 
       110        120        130        140        150
EPVPSPAPTP AEAPGAPREA LASATEAEGG SPSPEAPDDP IGLFVMRPQD 
       160        170        180        190        200
GEVTVGGSIT FSARVAGASL LKPPMVKWFK GKWVDLSSKV GQHLQLHDSY 
       210        220        230        240        250
DRASKVYLFE LHITDAQATF TGGYRCEVST KDKFDSCNFN LTVHEAIGPG 
       260        270        280        290        300
DLDLRSAFRR TSLAGGGRRI SDSHEDAGTL DFSSLLKKSS SLRTRRDSRL 
       310        320        330        340        350
EAPAEEDVWE ILRQAPPSEY ERIAFQHGIT DLRGMLKRLK GMRRDEKKST 
       360        370        380        390        400
AFQKKLEPAY QVSKGHKIRL TVELANPDAE VKWLKNGQEI QMSGSKYIFE 
       410        420        430        440        450
SIGAKRTLTI SQCSLADDAA YQCVVGGEKC STELFVKEPP VLITRPLEDQ 
       460        470        480        490        500
LVMVGQRVEF ECEVSEEGAQ VKWLKDGVEL TREETFKYRF KKDGQRHHLI 
       510        520        530        540        550
INEATLEDAG HYALHTSGGQ ALAELIVQEK KLEVYQSIAD LTVGAKDQAV 
       560        570        580        590        600
FKCEVSDENV RGVWLKNGKE LVPDSRIKVS HIGRVHKLTI DDVTPADEAD 
       610        620        630        640        650
YSFVPEGFAS NLSAKLHFME VKIDFVPRQE PPKIHLDCPG RVPDTIVVVA 
       660        670        680        690        700
GNKLRLDVPI SGDPAPTVTW QKTITQGNKV PAGPAPDAPG DAGASDEWVF 
       710        720        730        740        750
DKKLLCETEG RVRVETTKDR SVFTLEGAEK EDEGVYIVTV KNPVGEDQVN 
       760        770        780        790        800
LTVKVIDVPD APAAPKISNV GEDSCTVQWE PPAYDGGQPI LGYILERKKK 
       810        820        830        840        850
KSYRWMRLNF DLLRELSLEA KRMIEGVVYE MRVYAVNAIG MSRPSPASQP 
       860        870        880        890        900
FMPIGPPSEP THLAVEDVSD TTVSLKWRPP ERVGAGGLDG YSVEYCREGG 
       910        920        930        940        950
SEWVAALQGL TEHTSLLVKD LPTGARLLFR VRAHNVAGPG APVTTKEPVT 
       960        970        980        990       1000
VQEILQRPRL QLPRHLRQTI HRRVGEPVNL LIPFQGRPRP QVTWTKEGQP 
      1010       1020       1030       1040       1050
LAGEEVSIRN SPTDTILFIR AARRTHSGTY QVTLRIENME DEATLVLQIV 
      1060       1070       1080       1090       1100
DKPSPPQDIR VAEAWGFNVA LEWKPPQDDG NTEIWGYTVQ KADKKTMEWF 
      1110       1120       1130       1140       1150
TVLEHYRRTH CVVSELIIGN GYYFRVFSHN MVGPSDKAAT TKEPVFIPKA 
      1160       1170       1180       1190       1200
GITYESPSYK ALDFLEAPSF TRPLVNRSVI AGYNATLSCA VRGSPKPNIS 
      1210       1220       1230       1240       1250
WFKNGLDLRD DARFRTFSKQ GLLTLEIRKP CPFDGGIYVC RATNLQGEAQ 
      1260 
CECRLEVRVP Q
Length:1,261
Mass (Da):139,416
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9635E0E5FB6F632
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2GWG7A0A3Q2GWG7_HORSE
Myosin binding protein C3
MYBPC3
1,261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2LR21A0A3Q2LR21_HORSE
Myosin binding protein C3
MYBPC3
1,261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000029091; ENSECAP00000023065; ENSECAG00000024318

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6ZHP7

Genome annotation databases

EnsembliENSECAT00000029091; ENSECAP00000023065; ENSECAG00000024318

Organism-specific databases

VGNCiVGNC:59276, MYBPC3

Phylogenomic databases

GeneTreeiENSGT00940000157698
HOGENOMiCLU_006405_1_1_1
InParanoidiF6ZHP7
TreeFamiTF334735

Gene expression databases

BgeeiENSECAG00000024318, Expressed in multi-cellular organism and 16 other tissues

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR040849, MyBP-C_THB
PfamiView protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 8 hits
PF18362, THB, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00409, IG, 8 hits
SM00408, IGc2, 5 hits
SUPFAMiSSF48726, SSF48726, 8 hits
SSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZHP7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZHP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: December 2, 2020
This is version 50 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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