UniProtKB - F6ZHD6 (F6ZHD6_MACMU)
Protein
Submitted name:
Krueppel-like factor 10 isoform a
Gene
KLF10
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Molecular functioni
- core promoter sequence-specific DNA binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- bone mineralization Source: Ensembl
- cellular response to starvation Source: Ensembl
- circadian rhythm Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatic stem cell population maintenance Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Krueppel-like factor 10 isoform aImportedSubmitted name: Kruppel like factor 10Imported |
Gene namesi | Name:KLF10Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:73817, KLF10 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSMMUG00000018815, Expressed in lung and 22 other tissues |
ExpressionAtlasi | F6ZHD6, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 369 – 398 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 399 – 428 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 429 – 456 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
OMAi | QMVPLPT |
OrthoDBi | 582598at2759 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6ZHD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNFGASLQQ TAEERMKMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC
60 70 80 90 100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD
110 120 130 140 150
FEPSQVSNLM APAPSTVHFK SLSDTARPHI AAPFKEEEKS PGSAPKLPKA
160 170 180 190 200
QATSVIRHTA DAQLCNHQSC PVKAASILNY QDNSFRRRTH LTVEAARKNI
210 220 230 240 250
PCAAVSPNRS KCERSTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP
260 270 280 290 300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ASNPVVTTVV PSTPPSQPPA
310 320 330 340 350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6ZHF2 | F6ZHF2_MACMU | Kruppel like factor 10 | KLF10 | 465 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU322448 mRNA Translation: AFE66204.1 JU472205 mRNA Translation: AFH29009.1 JV048087 mRNA Translation: AFI38158.1 |
RefSeqi | NP_001253406.1, NM_001266477.1 |
Genome annotation databases
Ensembli | ENSMMUT00000026457; ENSMMUP00000024765; ENSMMUG00000018815 |
GeneIDi | 693458 |
KEGGi | mcc:693458 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU322448 mRNA Translation: AFE66204.1 JU472205 mRNA Translation: AFH29009.1 JV048087 mRNA Translation: AFI38158.1 |
RefSeqi | NP_001253406.1, NM_001266477.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000024765 |
Genome annotation databases
Ensembli | ENSMMUT00000026457; ENSMMUP00000024765; ENSMMUG00000018815 |
GeneIDi | 693458 |
KEGGi | mcc:693458 |
Organism-specific databases
CTDi | 7071 |
VGNCi | VGNC:73817, KLF10 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
OMAi | QMVPLPT |
OrthoDBi | 582598at2759 |
TreeFami | TF315506 |
Gene expression databases
Bgeei | ENSMMUG00000018815, Expressed in lung and 22 other tissues |
ExpressionAtlasi | F6ZHD6, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6ZHD6_MACMU | |
Accessioni | F6ZHD6Primary (citable) accession number: F6ZHD6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |