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Entry version 66 (13 Feb 2019)
Sequence version 1 (18 Apr 2012)
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Protein

Nucleoprotein TPR

Gene

Tpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Plays a limited role in the regulation of nuclear protein export. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4615885 SUMOylation of DNA replication proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoprotein TPR
Alternative name(s):
NPC-associated intranuclear protein
Translocated promoter region and nuclear basket protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tpr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1922066 Tpr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004221001 – 2431Nucleoprotein TPRAdd BLAST2431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei326N6-acetyllysineBy similarity1
Modified residuei386N6-acetyllysineBy similarity1
Modified residuei419N6-acetyllysineBy similarity1
Modified residuei453PhosphoserineBy similarity1
Modified residuei502N6-acetyllysineBy similarity1
Modified residuei531N6-acetyllysineBy similarity1
Modified residuei551N6-acetyllysineCombined sources1
Modified residuei596PhosphoserineBy similarity1
Modified residuei597PhosphoserineBy similarity1
Modified residuei706PhosphoserineBy similarity1
Modified residuei787N6-acetyllysineCombined sources1
Modified residuei797N6-acetyllysineBy similarity1
Modified residuei822N6-acetyllysineCombined sources1
Modified residuei829N6-acetyllysineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1760N6-acetyllysineCombined sources1
Modified residuei1762PhosphothreonineBy similarity1
Modified residuei1963PhosphoserineBy similarity1
Modified residuei2102PhosphoserineBy similarity1
Modified residuei2105PhosphoserineBy similarity1
Modified residuei2116PhosphoserineBy similarity1
Modified residuei2118PhosphoserineBy similarity1
Modified residuei2141PhosphoserineCombined sources1
Modified residuei2174Omega-N-methylarginineCombined sources1
Modified residuei2179Omega-N-methylarginineCombined sources1
Modified residuei2184PhosphothreonineCombined sources1
Modified residuei2205PhosphothreonineBy similarity1
Modified residuei2223PhosphoserineCombined sources1
Modified residuei2231Omega-N-methylarginineCombined sources1
Modified residuei2411Asymmetric dimethylarginineCombined sources1
Modified residuei2413Asymmetric dimethylarginineCombined sources1
Modified residuei2422Asymmetric dimethylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminal region) by MAPK1/ERK2 and stabilizes the interaction between these two proteins (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
F6ZDS4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
F6ZDS4

MaxQB - The MaxQuant DataBase

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MaxQBi
F6ZDS4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
F6ZDS4

PeptideAtlas

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PeptideAtlasi
F6ZDS4

PRoteomics IDEntifications database

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PRIDEi
F6ZDS4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
F6ZDS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
F6ZDS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, liver, kidney, spleen, lung and skeletal muscles.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Expressed at the mid two-cell stage and in the embryo at 7, 11, 15 and 17 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000006005 Expressed in 294 organ(s), highest expression level in cochlea

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
F6ZDS4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
F6ZDS4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Part of the nuclear pore complex (NPC). Associates with the XPO1/CRM1-mediated nuclear export complex, the Importin alpha/Importin beta receptor and the dynein 1 complex. Interacts (via C-terminal domain) with the KPNB1; the interaction occurs in a RanGTP-dependent manner. Interacts (via C-terminal region and phosphorylated form) with MAPK1/ERK2 (via phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation. Interacts with MAPK3/ERK1; the interaction increases following EGF stimulation. Interacts (via coiled coil region) with NUP153; the interaction is direct. Interacts with HSF1; the interaction increases in a stress-responsive manner and stimulates export of stress-induced HSP70 mRNA. Interacts with huntingtin/HTT; the interaction is inhibited by aggregated huntingtin/HTT forms with expanded polyglutamine stretch. Interacts with MAD1L1 (via N-terminal region), MAD2L1, and TTK; the interactions occurs in a microtubule-independent manner. Interacts (via middle region) with DYNLL1. Interacts with DCTN1, dynein, NUP153 and tubulin. Interacts with MTA1 (By similarity). Interacts with IFI204 (via C-terminal region). Interacts with IFI203.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
224509, 12 interactors

Protein interaction database and analysis system

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IntActi
F6ZDS4, 3 interactors

Molecular INTeraction database

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MINTi
F6ZDS4

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000117616

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
F6ZDS4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
F6ZDS4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 87Sufficient for interaction with TPRBy similarityAdd BLAST11
Regioni88 – 191Necessary for interaction with HSF1By similarityAdd BLAST104
Regioni511 – 587Necessary for association to the NPCBy similarityAdd BLAST77
Regioni1292 – 1394Necessary for interaction with HSF1By similarityAdd BLAST103
Regioni1882 – 1937Sufficient and essential for mediating its nuclear importBy similarityAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili98 – 444Sequence analysisAdd BLAST347
Coiled coili486 – 678Sequence analysisAdd BLAST193
Coiled coili736 – 1246Sequence analysisAdd BLAST511
Coiled coili1289 – 1494Sequence analysisAdd BLAST206
Coiled coili1547 – 1700Sequence analysisAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 77Ala-richAdd BLAST45
Compositional biasi2010 – 2081Asp-richAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain mediates intranuclear attachment to the nuclear pore complex. The C-terminal domain mediates its nuclear import (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TPR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4674 Eukaryota
ENOG410XSA1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111014

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG009158

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
F6ZDS4

KEGG Orthology (KO)

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KOi
K09291

Database of Orthologous Groups

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OrthoDBi
20957at2759

TreeFam database of animal gene trees

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TreeFami
TF350364

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012929 TPR/MLP1

Pfam protein domain database

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Pfami
View protein in Pfam
PF07926 TPR_MLP1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F6ZDS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSGGSASRS GHRGVPMTSR GFDGSRRGSL RRAGARETAS EAADGAAPAA
60 70 80 90 100
GLRASPCSLA SPSAAAAVAA IPADMAAVLQ QVLERPELNK LPKSTQNKLE
110 120 130 140 150
KFLAEQQSEI DCLKGRHEKF KVESEQQYFE IEKRLSQSQE RLVTETRECQ
160 170 180 190 200
NLRLELEKLN NQVKVLTEKT KELETAQDRN LGIQSQFTRA KEELEAEKRD
210 220 230 240 250
LIRTNERLSQ EVEYLTEDVK RLNEKLKESN TTKGELQLKL DELQASDVAV
260 270 280 290 300
KYREKRLEQE KELLHNQNSW LNTELKTKTD ELLALGREKG NEILELKCNL
310 320 330 340 350
ENKKEEVLRL EEQMNGLKTS NEHLQKHVED LLTKLKEAKE QQASMEEKFH
360 370 380 390 400
NELNAHIKLS NLYKSAADDS EAKSNELTRA VDELHKLLKE AGEANKTIQD
410 420 430 440 450
HLLQVEESKD QMEKEMLEKI GKLEKELENA NDLLSATKRK GAILSEEELA
460 470 480 490 500
AMSPTAAAVA KIVKPGMKLT ELYNAYVETQ DQLLLEKQEN KRINKYLDEI
510 520 530 540 550
VKEVEAKAPI LKRQREEYER AQKAVASLSA KLEQAMKEIQ RLQEDTDKAN
560 570 580 590 600
KHSSVLERDN QRMEIQIKDL SQQIRVLLME LEEARGNHVI RDEEVSSADI
610 620 630 640 650
SSSSEVISQH LVSYRNIEEL QQQNQRLLFA LRELGETRER EEQETTSSKI
660 670 680 690 700
AELQHKLENS LAELEQLRES RQHQMQLVDS IVRQRDMYRI LLSQTTGMAI
710 720 730 740 750
PLQASSLDDI SLLSTPKRSS TSQTVSTPAP EPVIDSTEAI EAKAALKQLQ
760 770 780 790 800
EIFENYKKEK IDSEKLQNEQ LEKLQEQVTD LRSQNTKIST QLDFASKRYE
810 820 830 840 850
MLQDNVEGYR REITSLQERN QKLTATTQKQ EQIINTMTQD LRGANEKLAV
860 870 880 890 900
AEVRAENLKK EKEMLKLSEV RLSQQRESLL AEQRGQNLLL TNLQTIQGIL
910 920 930 940 950
ERSETETKQR LNSQIEKLEH EISHLKKKLE NEVEQRHTLT RNLDVQLLDT
960 970 980 990 1000
KRQLDTEINL HLNTKELLKN AQKDIATLKQ HLNNMEAQLA SQSTQRTGKG
1010 1020 1030 1040 1050
QPGDRDDVDD LKSQLRQAEE QVNDLKERLK TSTSNVEQYR AMVTSLEDSL
1060 1070 1080 1090 1100
NKEKQVTEEV HKNIEVRLKE SAEFQTQLEK KLMEVEKEKQ ELQDDKRKAI
1110 1120 1130 1140 1150
ESMEQQLSEL KKTLSTVQNE VQEALQRAST ALSNEQQARR DCQEQAKIAV
1160 1170 1180 1190 1200
EAQNKYEREL MLHAADVEAL QAAKEQVSKM TSIRQHLEET TQKAESQLLE
1210 1220 1230 1240 1250
CKASWEERER VLKDEVSKSV SRCEDLEKQN RLLHDQIEKL SDKVVTSMKD
1260 1270 1280 1290 1300
AVQAPLNVSL NEEGKSQEQI LEILRFIRRE KEIAETRFEV AQVESLRYRQ
1310 1320 1330 1340 1350
RVELLERELQ ELQDSLNVER EKVQVTAKTM AQHEELMKKT ETMNVVMETN
1360 1370 1380 1390 1400
KMLREEKERL EQNLQQMQAK VRKLELDILP LQEANAELSE KSGMLQAEKK
1410 1420 1430 1440 1450
LLEEDVKRWK ARNQQLINQQ KDPDTEEYRK LLSEKEIHTK RIQQLNEEVG
1460 1470 1480 1490 1500
RLKAEIARSN ASLTNNQNLI QSLREDLSKA RTEKEGIQKD LDAKIIDIQE
1510 1520 1530 1540 1550
KVKTITQVKK IGRRYKTQFE ELKAQQNKAM ETSTQSSGDH QEQHISVQEM
1560 1570 1580 1590 1600
QELKDTLSQS ETKTKSLEGQ VENLQKTLSE KETEARSLQE QTVQLQSELS
1610 1620 1630 1640 1650
RLRQDLQDKT TEEQLRQQMN EKTWKTLALA KSKITHLSGV KDQLTKEIEE
1660 1670 1680 1690 1700
LKQRNGALDQ QKDELDVRMT ALKSQYEGRI SRLERELREH QERHLEQRDE
1710 1720 1730 1740 1750
PQEPTNKAPE QQRQITLKTT PASGERGIAS TSDPPTANIK PTPVVSTPSK
1760 1770 1780 1790 1800
VTAAAMAGNK STPRASIRPM VTPATVTNPT TTPTATVMPT TQVESQEAMQ
1810 1820 1830 1840 1850
SEGPVEHVPV FGNASGSVRS TSPNVQPSIS QPILTVQQQT QATAFVQPTQ
1860 1870 1880 1890 1900
QSHPQIEPTN QELSPNIVEV VQSSPVERPS TSTAVFGTVS ATPSSSLPKR
1910 1920 1930 1940 1950
TREEEEDSTM EAGDQVSEDT VEMPLPKKLK MVTPVGTEEE VMAEESTDGE
1960 1970 1980 1990 2000
AETQAYNQDS QDSIGEGVTQ GDYTPMEDSE ETSQSLQIDL GPLQSDQQTT
2010 2020 2030 2040 2050
SSQDGQGKGD DVIVIDSDDE DDDEENDGEH EDYEEDEDDD DDEEDDTGMG
2060 2070 2080 2090 2100
DEGEDSNEGT GSADGNDGYE ADDAEGGDGT DPGTETEESM GGAESHQRAA
2110 2120 2130 2140 2150
DSQNSGEGNT SAAESSFSQE VAREQQPTSA SERQTPQAPQ SPRRPPHPLP
2160 2170 2180 2190 2200
PRLTIHAPPQ ELGPPVQRIQ MTRRQSVGRG LQLTPGIGGM QQHFFDDEDR
2210 2220 2230 2240 2250
TVPSTPTLVV PHRTDGFAEA IHSPQVAGVP RFRFGPPEDM PQTSSSHSDL
2260 2270 2280 2290 2300
GQLASQGGLG MYETPLFLAH EEESGGRSVP TTPLQVAAPV TVFTESTTSD
2310 2320 2330 2340 2350
ASEHASQSVP MVTTSTGTLS TTNETAAGDD GDEVFVEAES EGISSEAGLE
2360 2370 2380 2390 2400
IDSQQEEEPV QASDESDLPS TSQDPPSSSS VDTSSSQPKP FRRVRLQTTL
2410 2420 2430
RQGVRGRQFN RQRGISHAMG GRGGINRGNI N
Length:2,431
Mass (Da):273,990
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD21CEA4F9C2C27C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7M739Q7M739_MOUSE
Nuclear pore complex-associated int...
Tpr mCG_8530
2,357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RX08F6RX08_MOUSE
Nucleoprotein TPR
Tpr
611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R5D8F6R5D8_MOUSE
Nucleoprotein TPR
Tpr
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC161432 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39478.1
AJ298076 Genomic DNA Translation: CAC40701.1
AF490392 mRNA Translation: AAM03151.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35734.2

NCBI Reference Sequences

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RefSeqi
NP_598541.3, NM_133780.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.174256

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000124973; ENSMUSP00000117616; ENSMUSG00000006005

Database of genes from NCBI RefSeq genomes

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GeneIDi
108989

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:108989

UCSC genome browser

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UCSCi
uc007cyb.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161432 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39478.1
AJ298076 Genomic DNA Translation: CAC40701.1
AF490392 mRNA Translation: AAM03151.1
CCDSiCCDS35734.2
RefSeqiNP_598541.3, NM_133780.3
UniGeneiMm.174256

3D structure databases

SMRiF6ZDS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224509, 12 interactors
IntActiF6ZDS4, 3 interactors
MINTiF6ZDS4
STRINGi10090.ENSMUSP00000117616

Chemistry databases

BindingDBiF6ZDS4

PTM databases

iPTMnetiF6ZDS4
PhosphoSitePlusiF6ZDS4

Proteomic databases

EPDiF6ZDS4
jPOSTiF6ZDS4
MaxQBiF6ZDS4
PaxDbiF6ZDS4
PeptideAtlasiF6ZDS4
PRIDEiF6ZDS4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124973; ENSMUSP00000117616; ENSMUSG00000006005
GeneIDi108989
KEGGimmu:108989
UCSCiuc007cyb.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7175
MGIiMGI:1922066 Tpr

Phylogenomic databases

eggNOGiKOG4674 Eukaryota
ENOG410XSA1 LUCA
GeneTreeiENSGT00730000111014
HOVERGENiHBG009158
InParanoidiF6ZDS4
KOiK09291
OrthoDBi20957at2759
TreeFamiTF350364

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4615885 SUMOylation of DNA replication proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tpr mouse

Protein Ontology

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PROi
PR:F6ZDS4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006005 Expressed in 294 organ(s), highest expression level in cochlea
ExpressionAtlasiF6ZDS4 baseline and differential
GenevisibleiF6ZDS4 MM

Family and domain databases

InterProiView protein in InterPro
IPR012929 TPR/MLP1
PfamiView protein in Pfam
PF07926 TPR_MLP1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZDS4
Secondary accession number(s): Q8R4A0, Q921B9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: April 18, 2012
Last modified: February 13, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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