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Entry version 53 (12 Aug 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

LAMA3

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Basement membraneARBA annotation, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502381678431 – 3274Sequence analysisAdd BLAST3244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi316 ↔ 325PROSITE-ProRule annotation
Disulfide bondi388 ↔ 397PROSITE-ProRule annotation
Disulfide bondi440 ↔ 449PROSITE-ProRule annotation
Disulfide bondi486 ↔ 498PROSITE-ProRule annotation
Disulfide bondi506 ↔ 515PROSITE-ProRule annotation
Disulfide bondi531 ↔ 543PROSITE-ProRule annotation
Disulfide bondi533 ↔ 550PROSITE-ProRule annotation
Disulfide bondi552 ↔ 561PROSITE-ProRule annotation
Disulfide bondi596 ↔ 605PROSITE-ProRule annotation
Disulfide bondi649 ↔ 658PROSITE-ProRule annotation
Disulfide bondi1261 ↔ 1273PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1282 ↔ 1291PROSITE-ProRule annotation
Disulfide bondi1323 ↔ 1332PROSITE-ProRule annotation
Disulfide bondi1375 ↔ 1384PROSITE-ProRule annotation
Disulfide bondi1400 ↔ 1412PROSITE-ProRule annotation
Disulfide bondi1402 ↔ 1419PROSITE-ProRule annotation
Disulfide bondi1421 ↔ 1430PROSITE-ProRule annotation
Disulfide bondi1701 ↔ 1710PROSITE-ProRule annotation
Disulfide bondi1729 ↔ 1741PROSITE-ProRule annotation
Disulfide bondi1752 ↔ 1761PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6ZCR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000019238, Expressed in oviduct epithelium and 13 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6ZCR0, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 293Laminin N-terminalInterPro annotationAdd BLAST256
Domaini294 – 350Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini351 – 420Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini421 – 464Laminin EGF-likeInterPro annotationAdd BLAST44
Domaini486 – 530Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini531 – 583Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini585 – 625Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini626 – 678Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini1261 – 1306Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini1307 – 1350Laminin EGF-likeInterPro annotationAdd BLAST44
Domaini1351 – 1399Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini1400 – 1450Laminin EGF-likeInterPro annotationAdd BLAST51
Domaini1471 – 1648Laminin IV type AInterPro annotationAdd BLAST178
Domaini1662 – 1710TNFR-CysInterPro annotationAdd BLAST49
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1662 – 1710TNFR-CysPROSITE-ProRule annotationAdd BLAST49
Domaini1682 – 1728Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini1729 – 1781Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini2329 – 2530LAM_G_DOMAINInterPro annotationAdd BLAST202
Domaini2537 – 2699LAM_G_DOMAINInterPro annotationAdd BLAST163
Domaini2706 – 2866LAM_G_DOMAINInterPro annotationAdd BLAST161
Domaini2927 – 3091LAM_G_DOMAINInterPro annotationAdd BLAST165
Domaini3098 – 3271LAM_G_DOMAINInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2894 – 2928DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1855 – 1910Sequence analysisAdd BLAST56
Coiled coili1918 – 1938Sequence analysisAdd BLAST21
Coiled coili1960 – 1987Sequence analysisAdd BLAST28
Coiled coili1995 – 2015Sequence analysisAdd BLAST21
Coiled coili2037 – 2074Sequence analysisAdd BLAST38
Coiled coili2078 – 2105Sequence analysisAdd BLAST28
Coiled coili2118 – 2138Sequence analysisAdd BLAST21
Coiled coili2278 – 2298Sequence analysisAdd BLAST21
Coiled coili2302 – 2322Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001729_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6ZCR0

TreeFam database of animal gene trees

More...
TreeFami
TF335359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR001368, TNFR/NGFR_Cys_rich_reg

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 12 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 2 hits
PF06009, Laminin_II, 1 hit
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 14 hits
SM00281, LamB, 1 hit
SM00282, LamG, 5 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit
PS50050, TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6ZCR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAARARGW APRRVLLLLL LLLLPAVCAA ARESPAAARL SLHPPYFNLA
60 70 80 90 100
EAAKIWATAT CGEREPGGAR PRPELYCKLV GGPTAPGSGH TIQGQFCDYC
110 120 130 140 150
NSEDPRRAHP ITNAIDGSER WWQSPPLSSG TRYNKVNVTL DLGQLFHVAY
160 170 180 190 200
VLIKFANSPR PDLWVLERSV DFGSTYSPWQ YFAHSKVDCL EQFGREANMA
210 220 230 240 250
VTRDDDVLCT TEYSRIVPLE NGEVVVSLIN GRPGAKNFTF SHTLREFTKA
260 270 280 290 300
TNIRLRFLRT NTLLGHLISK AQRDPTVTRR YYYSIKDISI GGRCVCNGHA
310 320 330 340 350
DVCNANNPEK LFRCECRHHT CGETCDRCCA GYNQRRWRPG TWGQSNECEA
360 370 380 390 400
CNCHGHAIDC YYDPDVERQQ ASLNIQGIYA GGGVCINCQH NTAGVNCEKC
410 420 430 440 450
AKGYFRPYGI PLDAPDGCIP CSCNPEHAED CEQGSGRCTC KPNFQGDHCE
460 470 480 490 500
KCAAGYHNFP FCLRIPIFPI STPSPEDPVA GEIKGCDCNL EGVLPEICDA
510 520 530 540 550
QGRCLCRPGV EGPRCDACRS GFYSFPICQA CQCSALGSYQ TPCNPETGQC
560 570 580 590 600
ECRPGITGQR CDRCLSGAYD FPHCQGSSSA CDPAGTLDSS RGYCQCKPHV
610 620 630 640 650
EGPTCSICKP LYWNLATENP NGCSECQCHA GGTVSGIGEC GQRDGDCHCK
660 670 680 690 700
SHVSGDSCDT CEDGYFALEK SSYFGCQGCQ CDIGGAISPI CSGPGGVCQC
710 720 730 740 750
RAHIVGKACQ RPEDNYYFPD LHHMKYEIED GTTPNGRELR FGFDPLEFPG
760 770 780 790 800
FSWRGYAQMS PVQNEVKIML NVGTSSLTLF RVILRYINPG TEAVSGRVTI
810 820 830 840 850
YPSWGAAQSK EIIFLPSKEP AFVTVPGNGF ADPFSIGPGK WIACIKAEGV
860 870 880 890 900
LLDYLVLLPR DYYEASSLQL PVTEPCADAG PPQENCLLYQ HLPVTRFPCA
910 920 930 940 950
LACEARHFLL DGEPRPLAMS QPTPAHPVMA DLSGREVELR LRLRVPQVGR
960 970 980 990 1000
YVLLVEYATE VDQLSVVDVH MESSGSVLAG QVDIYSCKYS VLCRSAVTDG
1010 1020 1030 1040 1050
RSRIPVYELL ADADIRLKAH MARFLLHQIC IIPVEEFSTE YLRPQVRCIA
1060 1070 1080 1090 1100
SYGRFINQSA TCVSLAPETP PTALILDVPS GESYPLLPQD PSPSASVVTG
1110 1120 1130 1140 1150
VTLKAPQNQM TLRGLVPHGG RYVFVIHFYQ PAHPTFPAQV SVDRGRPRAG
1160 1170 1180 1190 1200
VFRASFCPHV LGCWDQVITE DQVEFDISEP EVAVTVKVPE GRSLVLVRVL
1210 1220 1230 1240 1250
VVPAENYDYQ ILHKKSVNKS FEFIANCGGN SFYTDPQTAS VFCKNSTRSL
1260 1270 1280 1290 1300
VALYHNGALP CECHPTGSIG HHCSPEGGQC PCRPNIIGRQ CTRCRTGYYG
1310 1320 1330 1340 1350
FPHCKPCSCG QHLCEEMTGK CLCPPRTVRP QCEVCETHSF SFHPLAGCKG
1360 1370 1380 1390 1400
CNCSRRGTLE AATPECDRDH GQCRCKPRIT GRQCDRCASG FYHFPECIPC
1410 1420 1430 1440 1450
HCNRDGTEPA VCDPGTGACL CKENVEGTEC NVCREGSFYL DPANPKGCTS
1460 1470 1480 1490 1500
CFCFGVNNHC HSTHKRRAKF VDMRGWRLET ADRADIPVSF NPGSSSVVAD
1510 1520 1530 1540 1550
LQELPSTVHS ASWVAPLSYL GDKVSSYGGF LTYQIKSFGL PGDMVLLEKK
1560 1570 1580 1590 1600
PDVQLTGYHM SIIYEEPNNP RPDRLYHGRV QVVEGNFRHA SSGAQVSREE
1610 1620 1630 1640 1650
LMMVLSRLEG VRLRGLYFTE TQRLTLSGVG LEEASDTGSG RRAQNVEMCA
1660 1670 1680 1690 1700
CPPDYTGDSC QGCSPGYYRD NKGLYTGRCV PCSCNGHSHR CQDGSGICIN
1710 1720 1730 1740 1750
CQHNTAGNHC ERCKEGHYRN AVQGSCMVCP CPHSNSFATG CVVTGGNVKC
1760 1770 1780 1790 1800
SCKPGYTGTQ CERCAPGYFG NPQKFGGSCQ PCNCNNNGHL GSCDPVTGDC
1810 1820 1830 1840 1850
INQEPKDDGP GEECDDCDSC VMTLLNDLAT MEGELRLVKS QLQGLSASAS
1860 1870 1880 1890 1900
TLEHMRHLET QTKDLRNQLL NYRSAISNHG SKMDGLEKEL SNLNHEFETL
1910 1920 1930 1940 1950
QEKVQINSRK VQALPNNVDR TTQRAKELDT KIKNVIRNVH MLNRIRSWLE
1960 1970 1980 1990 2000
KHQVENSGLV KSIRDSLNEY EAKLTDLRAM LQEAATQAKQ AAGLNRENQK
2010 2020 2030 2040 2050
TLESIKRQVK EMNSLQSDFN KYLATADASL LQTSAVLQLM RKSQEEYEKL
2060 2070 2080 2090 2100
AASLNEAKHE LRDKVKELSK SSSKTSLVVA AEKHAQSLQE LAKQLEEIKR
2110 2120 2130 2140 2150
NTSGDELVRC AVDAATAYEN ILNAIKAAED AADKATSASE SAHQTVIKEN
2160 2170 2180 2190 2200
LPRKAKTLSS NSEKLLNEAK ITQKKLQQEI SPALNNLQQT LKIMTVQKGL
2210 2220 2230 2240 2250
IDTNITTIRD DLRGIQRGDI DGMINSAKSI VRNANDITNE VLDGLTPIQT
2260 2270 2280 2290 2300
DVERIKDTYG STQSEDFNKA LGDADNSVKK LTNKLPDLLS KIESINQQLL
2310 2320 2330 2340 2350
PLGNISDNVD RIRELIQQAR DAANKVAVPM RFNGKSGVEV RLPNDLEDLK
2360 2370 2380 2390 2400
GYTSLSLFLQ RPDSRENGGT NNMFVMYLGK KDASRDYIGM AVVDGQLTCV
2410 2420 2430 2440 2450
YNLGEREAEL QVDQILTESE TQESVMDRVK FQRIYQFARL NYTKKATSSK
2460 2470 2480 2490 2500
PEATQPHDMD SGNSNTLLNL DPENAVFYVG GYPPDFRLPS RLRFPPYKGC
2510 2520 2530 2540 2550
IELDDLNENV LSLYNFKKTF NLNTTEVEPC RRRKEESDKN YFEGTGYARI
2560 2570 2580 2590 2600
PTQPNAPLPI FVQTIQTTVD RGLLFFAENQ DHFISLDIED GSLLVRYKLN
2610 2620 2630 2640 2650
SESPEEKGIR VIINDGKDHS IQIRIGKAQK LMRISVARED IKINGEIFDF
2660 2670 2680 2690 2700
STYYLGGIPI SIRERFNIST PAFRGCMKNL KKTTGVVRLN DTVGVTKKCS
2710 2720 2730 2740 2750
EDWKLVRSAS FSRGGQMSFT NLDFPLPSLF QASFGFQTFQ PGGILLHHQT
2760 2770 2780 2790 2800
RTSSLQVTLE DGHIELSTTD SSSPIFKSPQ TYMDGLLHYV SVISDTSGLR
2810 2820 2830 2840 2850
LLIDDQPLKN NQRLQGFSGS QQSLRLGGSH FEGCISNVFV HRSSQSPAVL
2860 2870 2880 2890 2900
DLASKSTKRE VSLGGCSLNE PPFLMLLKGS TRFNTAKTFS INQPLQDTPV
2910 2920 2930 2940 2950
ASPRSKERWR DAQSCPSPPK AQASHGALRF GDSPTSHLLF TVPQELLKSR
2960 2970 2980 2990 3000
SRFAVDVQTT SSRGLMFYTG TRNSFMALYL SKGRLVFALG AEGKKLKLKS
3010 3020 3030 3040 3050
KEKFNDGKWH TVAFGQDGEK ARLVVDGLRA REGSWPRSFT VSLRVPVYLG
3060 3070 3080 3090 3100
SPPSEKSKSL PQSSFVGCLR NLQLDSKPLA TPSVSFGVSP CSHGSLEKGI
3110 3120 3130 3140 3150
YFSQEGGHII LANSVLLGPE FKLVFSIRPR SLTGILIHIG SQRGKHLCVY
3160 3170 3180 3190 3200
MEAGKVTASV DSEAGGILTS VTPKRSLCDG QWHRVAVTIK KHILHLELDT
3210 3220 3230 3240 3250
ENSYTAGQLP FPPASAREPL HIGGVPANLQ TLKLPVWKSF FGCVKNVQVN
3260 3270
HIPVPVTEAV EVQGTVSLNG CPDH
Length:3,274
Mass (Da):360,622
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F86FDC9D06A92F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HXJ3A0A3Q2HXJ3_HORSE
Uncharacterized protein
LAMA3
3,331Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q8N4F6Q8N4_HORSE
Uncharacterized protein
LAMA3
1,724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000020488; ENSECAP00000016818; ENSECAG00000021277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Proteomic databases

PaxDbiF6ZCR0

Genome annotation databases

EnsembliENSECAT00000020488; ENSECAP00000016818; ENSECAG00000021277

Phylogenomic databases

GeneTreeiENSGT00940000155638
HOGENOMiCLU_001729_1_0_1
InParanoidiF6ZCR0
TreeFamiTF335359

Gene expression databases

BgeeiENSECAG00000019238, Expressed in oviduct epithelium and 13 other tissues
ExpressionAtlasiF6ZCR0, baseline

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR001368, TNFR/NGFR_Cys_rich_reg
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 12 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 2 hits
PF06009, Laminin_II, 1 hit
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 9 hits
SM00180, EGF_Lam, 14 hits
SM00281, LamB, 1 hit
SM00282, LamG, 5 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF49899, SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit
PS50050, TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZCR0_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZCR0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: August 12, 2020
This is version 53 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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