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Entry version 50 (05 Jun 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

BCOR

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCORImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:58992 BCOR

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6ZCL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000005995 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1397 – 1502ANK_REP_REGIONInterPro annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1431 – 1463ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1464 – 1496ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni269 – 316DisorderedSequence analysisAdd BLAST48
Regioni358 – 406DisorderedSequence analysisAdd BLAST49
Regioni508 – 609DisorderedSequence analysisAdd BLAST102
Regioni705 – 729DisorderedSequence analysisAdd BLAST25
Regioni782 – 815DisorderedSequence analysisAdd BLAST34
Regioni1001 – 1266DisorderedSequence analysisAdd BLAST266
Regioni1330 – 1350DisorderedSequence analysisAdd BLAST21
Regioni1362 – 1386DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi272 – 293PolarSequence analysisAdd BLAST22
Compositional biasi508 – 587PolarSequence analysisAdd BLAST80
Compositional biasi1001 – 1075PolyampholyteSequence analysisAdd BLAST75
Compositional biasi1099 – 1133PolyampholyteSequence analysisAdd BLAST35
Compositional biasi1134 – 1148BasicSequence analysisAdd BLAST15
Compositional biasi1149 – 1168PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1176 – 1190PolarSequence analysisAdd BLAST15
Compositional biasi1191 – 1210PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1227 – 1252PolarSequence analysisAdd BLAST26
Compositional biasi1362 – 1378PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHDH Eukaryota
ENOG410YT00 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6ZCL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKPGRQG

TreeFam database of animal gene trees

More...
TreeFami
TF333317

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR031628 BCOR
IPR032365 PUFD
IPR038227 PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF15808 BCOR, 1 hit
PF16553 PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6ZCL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNKAFRERR VNTALARSLT GPGKVDATTA HRIDGLAALS MDRTGLIREG
60 70 80 90 100
LRVPGNIVYS SLCGLGSEKG REAATSTLGG LGFSSERNPE MQFKPNTPET
110 120 130 140 150
VEASAVSGKP PNGFSAIYKT PPGIQKSAVP TAETLGLDRP ASDKQSPLNI
160 170 180 190 200
NGASYLRLPW VNPYMEGATP AIYPFLDSPN KYSLNMYKAL LPQQSYSLAQ
210 220 230 240 250
PLYSPVCTNG ERFLYLPPPH YVSPHIPSSL ASPMRLSTPS ASPAIPPLVH
260 270 280 290 300
CADKSLPWKM GVSPGNPVDS HAYPHIQNSK QPRVPSAKVT SSLPGDTALL
310 320 330 340 350
LPPSPRPSPR VHLPSQPAAD TYSEFHKHYA RISTSPSVTL SKPYMTVSSE
360 370 380 390 400
FPAARLSNGK YPKAPEGAES AQPVPGHARK AAGQDRKDGG SPPLLEKQTV
410 420 430 440 450
TKDITDKPLD LSSKVVDVDA SKADHMKKMA PTVLVHSRAG SGLVLSGSEI
460 470 480 490 500
PKETLSPPGN GCALYRSEII STAPSSWVVP GPSPNEENNG KGMPLKNKAL
510 520 530 540 550
DWAIPQQRSS SCPRMGGTDA VVTNVSGSVS SAGRPASASP APNANADGSK
560 570 580 590 600
TSRSSVDTTP SVIQHVGQPP TTPAKHSGGT SSKGAKAGNP EPSFKANENG
610 620 630 640 650
LPPSSIFLSP TEAFRSPPIP YPRSYLPYPA PEGIAISPLS LHGKGPVYPH
660 670 680 690 700
PVLLPSGSLF PGHLAPKPGL PYGLPTGRPE FVTYQDALGL GMVHPMLIPH
710 720 730 740 750
TPIEITKEEK PERRSRSHER GRYEDPTLRN RFSEMLEAGS TKLHPEVPAE
760 770 780 790 800
KNLKPSPSWN QGKTVVKSDK LVYVDLLREE PDAKPDTNVS KPGFAAESVG
810 820 830 840 850
QSTEPAKPPT DPALQPHRDF IALREEMGRV GDFHEAYTFK QAPGQSVFSL
860 870 880 890 900
SKENVPAATT KENLGVPVST PFLEPTLGSD GPAVTFGKTQ EDPKPFCVGS
910 920 930 940 950
APPSVDVTPT YTKDGADEAE SSDGKVLKPK PSKLAKRIAN SAGYVGDRFK
960 970 980 990 1000
CVTTELYADS SQLSREQRAL QMEGLQEDSI LCLPAAYCER AMMRFSELEM
1010 1020 1030 1040 1050
KEREGGHPTT KDSEVCKFSP TDWERLKGNQ DKKPKSVALE EAIADQNDSE
1060 1070 1080 1090 1100
RCEDSAGNKQ DPFEAPEDKD LPVENYFVDR QPASEPPADQ AATDMPHDPT
1110 1120 1130 1140 1150
LQLEKKRKIS DDSKHADTTV EELPEDPLLK IKRKRVSKGL HPKKQRHLLH
1160 1170 1180 1190 1200
LRERWEQQVS ESKPGRQGRK EVTQAIQPRA VTQGTNISEE KASRKGTEAR
1210 1220 1230 1240 1250
GNRSWLEESL KSSDNEQGLP VFSGSPPMKS LLSTNASGKK QTQPSCTPAS
1260 1270 1280 1290 1300
RPSAKRQKIE ESQKTDVLCT DEEEDCQAAC LLQKYTGNSE KPSGKRLCKT
1310 1320 1330 1340 1350
KHLIPQEPRR GLSLTGDYYA ENADGKGTVR RFRKRPEPGS HYELSPAKQD
1360 1370 1380 1390 1400
QKTFDRLQQL LPASQSSQLP RSGSPPETSQ SRPMPPEARR LIVNKNAGET
1410 1420 1430 1440 1450
LLQRAARLGY EEVVLYCLEN KICDVNHRDN AGYCALHEAC ARGWLNIVGH
1460 1470 1480 1490 1500
LLEYGADVNC SAQDGTRPLH DAVENDHLEI VRLLLSYGAD PTLATYSGRT
1510 1520 1530 1540 1550
IMKMTHSELM EKFLTDYLND LQGRSDDDAN GAWEFYGSSV CEPPNESGCD
1560 1570 1580 1590 1600
VLANPPGPED QDDDDEAYSD VFEFEFSKSP LLPCYNVQVS VTQGPRNWLL
1610 1620 1630 1640 1650
LSDVLKKLKM SSRIFRCNFP NVEIVNITEA EFYRQVSASL LFSCSKDLEA
1660 1670 1680 1690 1700
FNPESNELVH LVEFTNELQT LLGSSVEWLH PNDMVSDDYW KSPQTSGGNK

REKSK
Length:1,705
Mass (Da):185,873
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B4581CFF8B8B0E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2LI62A0A3Q2LI62_HORSE
Uncharacterized protein
BCOR
1,733Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU79A0A3Q2GU79_HORSE
Uncharacterized protein
BCOR
1,715Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000006761; ENSECAP00000004841; ENSECAG00000005995

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6ZCL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000006761; ENSECAP00000004841; ENSECAG00000005995

Organism-specific databases

VGNCiVGNC:58992 BCOR

Phylogenomic databases

eggNOGiENOG410IHDH Eukaryota
ENOG410YT00 LUCA
GeneTreeiENSGT00940000153737
InParanoidiF6ZCL8
OMAiSKPGRQG
TreeFamiTF333317

Gene expression databases

BgeeiENSECAG00000005995 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR031628 BCOR
IPR032365 PUFD
IPR038227 PUFD_som_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF15808 BCOR, 1 hit
PF16553 PUFD, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZCL8_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZCL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: June 5, 2019
This is version 50 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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