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Entry version 59 (29 Sep 2021)
Sequence version 3 (17 Jun 2020)
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Protein
Submitted name:

Protein Wiz

Gene

Wiz

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein WizImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WizImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1332638, Wiz

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000024050

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
F6ZBR8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
F6ZBR8

PeptideAtlas

More...
PeptideAtlasi
F6ZBR8

PRoteomics IDEntifications database

More...
PRIDEi
F6ZBR8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
350975

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024050, Expressed in olfactory bulb and 286 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6ZBR8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
F6ZBR8, 1 interactor

Molecular INTeraction database

More...
MINTi
F6ZBR8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F6ZBR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 170C2H2-typeInterPro annotationAdd BLAST23
Domaini321 – 343C2H2-typeInterPro annotationAdd BLAST23
Domaini451 – 478C2H2-typeInterPro annotationAdd BLAST28
Domaini635 – 662C2H2-typeInterPro annotationAdd BLAST28
Domaini805 – 827C2H2-typeInterPro annotationAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 95DisorderedSequence analysisAdd BLAST95
Regioni115 – 136DisorderedSequence analysisAdd BLAST22
Regioni250 – 315DisorderedSequence analysisAdd BLAST66
Regioni502 – 583DisorderedSequence analysisAdd BLAST82
Regioni695 – 759DisorderedSequence analysisAdd BLAST65
Regioni871 – 962DisorderedSequence analysisAdd BLAST92
Regioni967 – 986DisorderedSequence analysisAdd BLAST20
Regioni1037 – 1059DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 83Pro residuesSequence analysisAdd BLAST51
Compositional biasi277 – 309Polar residuesSequence analysisAdd BLAST33
Compositional biasi545 – 562Pro residuesSequence analysisAdd BLAST18
Compositional biasi935 – 951Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012432_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQEHKVG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F6ZBR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASTAQCRV TKAESKAAAG PRAGGARERA PTGAPSPGPP SPGPVVLPAP
60 70 80 90 100
PAPPPPPPPP PPLPPSRDGP KAEPEPGPAP ASAPAPGLCS EENTMVAMDL
110 120 130 140 150
GSPLLPKKSL PVSGTLEQVA SRLSSKVAAE VPHGSKQELP DLKAQSLTTC
160 170 180 190 200
EVCGACFETR KGLSSHARSH LRQLGVAESE SSGAPIDLLY ELVKQKGLPD
210 220 230 240 250
APLGLTPSLT KKSNSPKEFL AGAARPGLLT LAKPMDAPAV NKAIKSPPGF
260 270 280 290 300
SAKGLTHPSS SPLLKKAPLT LAGSPTPKNP EDKSPQLSLS PRPTSPKAQW
310 320 330 340 350
PQSEDEGPLN LTLDSDGGRE LDCQLCGAWF ETRKGLSSHA RAHLRHLGVS
360 370 380 390 400
DPDAKGSPID VLHGLIRRDG IQIRLPPGRG ALAQLGRPPS ASTALSLLPP
410 420 430 440 450
PPPAKKAKLK ASGMASPWGK QDLSAAGIFW ASDVEPSPLN LSSGPEPTRD
460 470 480 490 500
IRCEFCGEFF ENRKGLSSHA RSHLRQMGVT EWYVNGSPID TLREILKRRT
510 520 530 540 550
QSRPGGHLHP PGPSPKALAK VLSTGGPGSS LEARSPSDLH ISPLTKKLPP
560 570 580 590 600
PPGSPLGHSP TASPPPTARK MFSGLATPSL PKKLKPEHMR VEIKREMLPG
610 620 630 640 650
TLHGEPHPSE GPWGTPREDM APLNLSARAE PVRDIRCEFC GEFFENRKGL
660 670 680 690 700
SSHARSHLRQ MGVTEWSVNG SPIDTLREIL KKKSKLCLIK KEPPAGDLAP
710 720 730 740 750
ALTEDGSPTA APGALHSPLP LSPLASRPGK PGAGPTQVPR ELSLSPITGS
760 770 780 790 800
KPSAASYLGP VATKRPLQED RFLPAEVKAK TYIQTELPFK AKTLHEKTSH
810 820 830 840 850
SSTEACCELC GLYFENRKAL ASHARAHLRQ FGVTEWCVNG SPIETLSEWI
860 870 880 890 900
KHRPQKVGAY RSYIQGGRPF TKKFRSAGHG RDSDKRPPLG LAPGGLSLVG
910 920 930 940 950
RSAGGEPGLE AGRAADSGER PLATSPPGTV KSEEHQRQNI NKFERRQARP
960 970 980 990 1000
SDASAARGGE EVNDLQQKLE EVRQPPPRVR PVPSLVPRPP QTSLVKFVGN
1010 1020 1030 1040 1050
IYTLKCRFCE VEFQGPLSIQ EEWVRHLQRH ILEMNFSKAD PPPEEPQAPQ

AQTAAVEAP
Length:1,059
Mass (Da):112,676
Last modified:June 17, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14F11F7B62F19385
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88286WIZ_MOUSE
Protein Wiz
Wiz
1,684Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E8J8G5E8J8_MOUSE
Protein Wiz
Wiz
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BAG6A0A494BAG6_MOUSE
Protein Wiz
Wiz
1,685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1G2E9Q1G2_MOUSE
Protein Wiz
Wiz
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZC6E9PZC6_MOUSE
Protein Wiz
Wiz
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5W4E9Q5W4_MOUSE
Protein Wiz
Wiz
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q869E9Q869_MOUSE
Protein Wiz
Wiz
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5R9E9Q5R9_MOUSE
Protein Wiz
Wiz
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_006524128.1, XM_006524065.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000169488; ENSMUSP00000126253; ENSMUSG00000024050

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22404

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006524128.1, XM_006524065.3

3D structure databases

SMRiF6ZBR8
ModBaseiSearch...

Protein-protein interaction databases

IntActiF6ZBR8, 1 interactor
MINTiF6ZBR8

Proteomic databases

EPDiF6ZBR8
jPOSTiF6ZBR8
PeptideAtlasiF6ZBR8
PRIDEiF6ZBR8
ProteomicsDBi350975

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
7541, 97 antibodies

The DNASU plasmid repository

More...
DNASUi
22404

Genome annotation databases

EnsembliENSMUST00000169488; ENSMUSP00000126253; ENSMUSG00000024050
GeneIDi22404

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
58525
MGIiMGI:1332638, Wiz
VEuPathDBiHostDB:ENSMUSG00000024050

Phylogenomic databases

GeneTreeiENSGT00940000159979
HOGENOMiCLU_012432_1_0_1
OMAiSQEHKVG

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Wiz, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024050, Expressed in olfactory bulb and 286 other tissues
ExpressionAtlasiF6ZBR8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6ZBR8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ZBR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: June 17, 2020
Last modified: September 29, 2021
This is version 59 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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