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Protein

Non-specific serine/threonine protein kinase

Gene

PAK4

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:PAK4Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 19

Expressioni

Gene expression databases

BgeeiENSMMUG00000013140 Expressed in 13 organ(s), highest expression level in rectum
ExpressionAtlasiF6Z9I4 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 24CRIBInterPro annotationAdd BLAST14
Domaini177 – 428Protein kinaseInterPro annotationAdd BLAST252

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
GeneTreeiENSGT00930000150829

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

F6Z9I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP
60 70 80 90 100
KPLIDPACIT SIQPGAPKGE PHDVAPNGPS AGGLAVPQSS SSSSRPPTRA
110 120 130 140 150
RGAPSPGVLG PHASEPQLAP PAHTPAAPAA PAAPAAPAVP GPPGPRSPQR
160 170 180 190 200
EPQRVSHEQF RAALQLVVDP GDPRSYLDNF IKIGEGSTGI VCIATVRSSG
210 220 230 240 250
KLVAVKKMDL RKQQRRELLF NEVVIMRDYQ HENVVEMYNS YLVGDELWVV
260 270 280 290 300
MEFLEGGALT DIVTHTRMNE EQIAAVCLAV LQALSVLHAQ GVIHRDIKSD
310 320 330 340 350
SILLTHDGRV KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP ELISRLPYGP
360 370 380 390 400
EVDIWSLGIM VIEMVDGEPP YFNEPPLKAM KMIRDNLPPR LKNLHKVSPS
410 420 430 440
LKGFLDRLLV RDPAHRATAA ELLKHPFLAK AGPPASIVPL MRQNRTR
Length:447
Mass (Da):49,029
Last modified:November 30, 2016 - v2
Checksum:i7BD50A260555B252
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z9H7F6Z9H7_MACMU
Non-specific serine/threonine prote...
PAK4
600Annotation score:
A0A1D5QPF3A0A1D5QPF3_MACMU
Non-specific serine/threonine prote...
PAK4
588Annotation score:
A0A1D5Q7X6A0A1D5Q7X6_MACMU
Uncharacterized protein
PAK4
178Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03021687 Genomic DNA No translation available.
RefSeqiXP_014979381.1, XM_015123895.1
UniGeneiMmu.20130

Genome annotation databases

EnsembliENSMMUT00000018438; ENSMMUP00000017265; ENSMMUG00000013140
GeneIDi696676

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03021687 Genomic DNA No translation available.
RefSeqiXP_014979381.1, XM_015123895.1
UniGeneiMmu.20130

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000018438; ENSMMUP00000017265; ENSMMUG00000013140
GeneIDi696676

Organism-specific databases

CTDi10298

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
GeneTreeiENSGT00930000150829

Gene expression databases

BgeeiENSMMUG00000013140 Expressed in 13 organ(s), highest expression level in rectum
ExpressionAtlasiF6Z9I4 baseline

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6Z9I4_MACMU
AccessioniPrimary (citable) accession number: F6Z9I4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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