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Protein

Methionine aminopeptidase

Gene

METAP1D

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161SubstrateUniRule annotation1
Metal bindingi178Divalent metal cation 1UniRule annotation1
Metal bindingi189Divalent metal cation 1UniRule annotation1
Metal bindingi189Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi252Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei259SubstrateUniRule annotation1
Metal bindingi284Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi315Divalent metal cation 1UniRule annotation1
Metal bindingi315Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Protein family/group databases

MEROPSiM24.001

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Gene namesi
Name:METAP1DImported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:20112 METAP1D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF6Z5G9

Expressioni

Gene expression databases

BgeeiENSECAG00000021599 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000019136

Structurei

3D structure databases

ProteinModelPortaliF6Z5G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 321Peptidase_M24InterPro annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2738 Eukaryota
COG0024 LUCA
GeneTreeiENSGT00390000002284
InParanoidiF6Z5G9
KOiK01265
OMAiSYFHGPP
OrthoDBiEOG091G0F4A
TreeFamiTF325318

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit

Sequencei

Sequence statusi: Complete.

F6Z5G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPSGVHRL VLRGCHRILS LPLNHIYLHK QSSSQQRRNF FFRRQREISH
60 70 80 90 100
SIVLPAAVSS AHPVPKHIKK PDYVTTGIVP DWGDSIEVKN EDQIQGLRQA
110 120 130 140 150
CQLARHVLLL AGKSLKVDMT TEEIDALVHQ EIISHDAYPS PLGYGGFPKS
160 170 180 190 200
VCTSVNNVLC HGIPDSRPLQ DGDIINIDVT VYYNGYHGDT SETFLVGNVD
210 220 230 240 250
ECGKKLVEVA RRCRDEAIAA CRAGAPFSVI GNTISRITHQ NGLQVCPHFV
260 270 280 290 300
GHGIGSYFHG HPEIWHHAND SDLLMEEGMA FTIEPIITEG SPEFKVLRMR
310 320 330
GTAVSLDNQR SAQFEHTILI TSGGAQILTQ LPHEA
Length:335
Mass (Da):36,989
Last modified:July 27, 2011 - v1
Checksum:i7E26BDC6431B05BD
GO

Sequence databases

RefSeqiXP_001917093.1, XM_001917058.4

Genome annotation databases

EnsembliENSECAT00000023117; ENSECAP00000019136; ENSECAG00000021599
GeneIDi100053063
KEGGiecb:100053063

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_001917093.1, XM_001917058.4

3D structure databases

ProteinModelPortaliF6Z5G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000019136

Protein family/group databases

MEROPSiM24.001

Proteomic databases

PaxDbiF6Z5G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000023117; ENSECAP00000019136; ENSECAG00000021599
GeneIDi100053063
KEGGiecb:100053063

Organism-specific databases

CTDi254042
VGNCiVGNC:20112 METAP1D

Phylogenomic databases

eggNOGiKOG2738 Eukaryota
COG0024 LUCA
GeneTreeiENSGT00390000002284
InParanoidiF6Z5G9
KOiK01265
OMAiSYFHGPP
OrthoDBiEOG091G0F4A
TreeFamiTF325318

Gene expression databases

BgeeiENSECAG00000021599 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6Z5G9_HORSE
AccessioniPrimary (citable) accession number: F6Z5G9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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