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Entry version 51 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Aminoadipate-semialdehyde dehydrogenase

Gene

AASDH

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Aminoadipate-semialdehyde dehydrogenaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AASDHImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:14893, AASDH

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000009502, Expressed in gluteus medius and 22 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033811

KEGG Orthology (KO)

More...
KOi
K00142

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCIDDEQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR009081, PP-bd_ACP
IPR018391, PQQ_beta_propeller_repeat
IPR002372, PQQ_repeat
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 1 hit
PF00550, PP-binding, 1 hit
PF13360, PQQ_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00564, PQQ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F6Z0S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLQELVHQA ASLYSDKIAV CFDECNNQPP VYYTYKTVIN AASELSNFLL
60 70 80 90 100
LHCDFQGIRA IGLYCHPGIN LPSWILGILQ VPAAYAPIDP DSPPALSIHF
110 120 130 140 150
MKKCNLKYIL VEKQQINKFK SSYETLLNYD TFTVEHNDIV LFRLHWKNVE
160 170 180 190 200
VSLMLNERKE KYEKEKMTNS TSSENSNEEK SEEHMDARLK HCLAYVLHTS
210 220 230 240 250
GTTGKPKIVR VPHACIVPNI QHFRVLFEIT QDDVLFLASP LTFDPSVVEI
260 270 280 290 300
FVALSSGASL LIVPTSVKVI PSKLAAVLFS HHRVTVLQAT PTLLRRFGSQ
310 320 330 340 350
LIKSTVLSTS TSLRVLALGG EAFPSLTVLK SWRGVGNKTQ IFNIYGITEV
360 370 380 390 400
SSWATFYRIP EKTLNSTLKC ELPVQLGFPL LGTVVEVRDT DGFAIQEGDG
410 420 430 440 450
QVFLGGRNRV CFLDDEVTVP LGTMRATGDF VTVKDGEIFF LGRKDSQIKR
460 470 480 490 500
HGKRLNIELV QQVAEGLQEV ESCAVTWYNQ EKLILFMVSK NDLVKDYIFE
510 520 530 540 550
ELQKHLPSHA IPDELVLIDS LPFTSHGKID VSELNKIYLN YINLKSECKL
560 570 580 590 600
NGKEELWEKL QHLWKSILSL SEDPLRIPDE SLFLNSGGDS LKSIRLLNEI
610 620 630 640 650
EKLVGTSVPG LLEIILNSSI LEIYNHIVQT VFPDEDLTFS KNYATKRKFS
660 670 680 690 700
DINQETSGKS LHQNSVMPLN CDKKINAFIA LSRGGQILSV NTTRPLTKLG
710 720 730 740 750
HCPSACSSDL ISQTNTQNVE SLNPPALSGK SKDPSCVAEF FSEEGTPVIE
760 770 780 790 800
AEKMELCVRW MSDTGKCVDA SPLVVIPAVD KSSATVYIGS HSHRMMAVDL
810 820 830 840 850
YSGKVKWEQI LGDRVESSAC VSKCGNFIVV GCYNGLVYVL KSSSGEKYWT
860 870 880 890 900
FTTEDAVKSS ATMDPTTGLL YIGSHDQHAY ALDIYKKKCV WKLKCGATVF
910 920 930 940 950
SSPCLSLTPH HLYFATLGGL LLAVNPATGN RIWKHSCGKP LFSSPRCCLQ
960 970 980 990 1000
YICIGCVDGN LLCFTHFGEQ VWQFCTSEPI FSSPCTSASE QEIFFGSHDC
1010 1020 1030 1040 1050
FIYCCNTKGH LQWKFETTSR VYSTPFNFHN YNRSDEMLLA AASTDGKLWI
1060 1070 1080 1090
LESKSGQLQS VYRLPGEVFS SPVVWESMLI IGCRNNYVYC LDLLGGNQK
Length:1,099
Mass (Da):122,705
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDA65D0004DD880F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2KZL1A0A3Q2KZL1_HORSE
Aminoadipate-semialdehyde dehydroge...
AASDH
1,036Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YVG5F6YVG5_HORSE
Aminoadipate-semialdehyde dehydroge...
AASDH
876Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HMH3A0A3Q2HMH3_HORSE
Aminoadipate-semialdehyde dehydroge...
AASDH
922Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I8P3A0A3Q2I8P3_HORSE
Aminoadipate-semialdehyde dehydroge...
AASDH
919Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_005608805.1, XM_005608748.2
XP_005608806.1, XM_005608749.2
XP_005608807.1, XM_005608750.2
XP_005608808.1, XM_005608751.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000057363; ENSECAP00000037227; ENSECAG00000009502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100053858

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecb:100053858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_005608805.1, XM_005608748.2
XP_005608806.1, XM_005608749.2
XP_005608807.1, XM_005608750.2
XP_005608808.1, XM_005608751.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000057363; ENSECAP00000037227; ENSECAG00000009502
GeneIDi100053858
KEGGiecb:100053858

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
132949
VGNCiVGNC:14893, AASDH

Phylogenomic databases

GeneTreeiENSGT00440000033811
KOiK00142
OMAiMCIDDEQ

Gene expression databases

BgeeiENSECAG00000009502, Expressed in gluteus medius and 22 other tissues

Family and domain databases

Gene3Di2.130.10.10, 2 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR036736, ACP-like_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR009081, PP-bd_ACP
IPR018391, PQQ_beta_propeller_repeat
IPR002372, PQQ_repeat
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF00550, PP-binding, 1 hit
PF13360, PQQ_2, 1 hit
SMARTiView protein in SMART
SM00564, PQQ, 6 hits
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Z0S7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Z0S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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