UniProtKB - F6Z0M9 (F6Z0M9_HORSE)
Protein
Flotillin
Gene
FLOT1
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- protease binding Source: Ensembl
GO - Biological processi
- axonogenesis Source: Ensembl
- cellular response to exogenous dsRNA Source: Ensembl
- dsRNA transport Source: Ensembl
- extracellular matrix disassembly Source: Ensembl
- plasma membrane raft assembly Source: Ensembl
- positive regulation of cell adhesion molecule production Source: Ensembl
- positive regulation of cell-cell adhesion mediated by cadherin Source: GO_Central
- positive regulation of cell junction assembly Source: GO_Central
- positive regulation of endocytosis Source: GO_Central
- positive regulation of heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of interferon-beta production Source: Ensembl
- positive regulation of myoblast fusion Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
- positive regulation of skeletal muscle tissue development Source: Ensembl
- positive regulation of synaptic transmission, dopaminergic Source: Ensembl
- positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
- protein kinase C signaling Source: GO_Central
- protein localization to membrane raft Source: Ensembl
- protein localization to plasma membrane Source: GO_Central
- protein stabilization Source: Ensembl
- regulation of neurotransmitter uptake Source: Ensembl
- regulation of receptor internalization Source: GO_Central
- regulation of Rho protein signal transduction Source: Ensembl
- response to endoplasmic reticulum stress Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: FlotillinUniRule annotation |
Gene namesi | Name:FLOT1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18063, FLOT1 |
Subcellular locationi
Cytoskeleton
- centriolar satellite Source: Ensembl
- cortical actin cytoskeleton Source: Ensembl
Endosome
- early endosome Source: Ensembl
Nucleus
- COP9 signalosome Source: Ensembl
Plasma Membrane
- basolateral plasma membrane Source: Ensembl
- external side of plasma membrane Source: Ensembl
- flotillin complex Source: GO_Central
- plasma membrane Source: GO_Central
- sarcolemma Source: Ensembl
Other locations
- adherens junction Source: Ensembl
- cell-cell contact zone Source: Ensembl
- cytoplasmic vesicle Source: GO_Central
- dopaminergic synapse Source: Ensembl
- lamellipodium Source: Ensembl
- uropod Source: Ensembl
Keywords - Cellular componenti
EndosomeARBA annotation, MembraneUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000022083, Expressed in chorionic villus and 22 other tissues |
Interactioni
Subunit structurei
Heterooligomeric complex.
UniRule annotationGO - Molecular functioni
- protease binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 266 | PHBInterPro annotationAdd BLAST | 183 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 242 – 262 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00560000077232 |
HOGENOMi | CLU_038134_1_0_1 |
InParanoidi | F6Z0M9 |
TreeFami | TF324879 |
Family and domain databases
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR031905, Flotillin_C IPR027705, Flotillin_fam |
PANTHERi | PTHR13806, PTHR13806, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF15975, Flot, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
i Sequence
Sequence statusi: Complete.
F6Z0M9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAQIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230 240 250
AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL QVAKTKQQIE
260 270 280 290 300
EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
310 320 330 340 350
EKTQLIMQAE AEAESVRMRG EAEAFAIGAR ARADAEQMSK KAEAFQLYQE
360 370 380 390 400
AAQLDMLLEK LPQVAEEISG PLTSAKKITL VSSGSGTMGA AKVTGEVLDI
410 420
LSRLPECVER LTGVSISQVN HKPLRTA
Sequence databases
RefSeqi | XP_005614774.1, XM_005614717.2 |
Genome annotation databases
Ensembli | ENSECAT00000023766; ENSECAP00000019710; ENSECAG00000022083 |
GeneIDi | 100050936 |
KEGGi | ecb:100050936 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005614774.1, XM_005614717.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6Z0M9 |
PRIDEi | F6Z0M9 |
Genome annotation databases
Ensembli | ENSECAT00000023766; ENSECAP00000019710; ENSECAG00000022083 |
GeneIDi | 100050936 |
KEGGi | ecb:100050936 |
Organism-specific databases
CTDi | 10211 |
VGNCi | VGNC:18063, FLOT1 |
Phylogenomic databases
GeneTreei | ENSGT00560000077232 |
HOGENOMi | CLU_038134_1_0_1 |
InParanoidi | F6Z0M9 |
TreeFami | TF324879 |
Gene expression databases
Bgeei | ENSECAG00000022083, Expressed in chorionic villus and 22 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR031905, Flotillin_C IPR027705, Flotillin_fam |
PANTHERi | PTHR13806, PTHR13806, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit PF15975, Flot, 1 hit |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6Z0M9_HORSE | |
Accessioni | F6Z0M9Primary (citable) accession number: F6Z0M9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |