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Entry version 60 (17 Jun 2020)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

Coiled-coil and C2 domain-containing protein 2A

Gene

Cc2d2a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Coiled-coil and C2 domain-containing protein 2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cc2d2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924487 Cc2d2a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F6YZ61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039765 Expressed in retina and 226 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F6YZ61

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini994 – 1154C2InterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 117DisorderedSequence analysisAdd BLAST117
Regioni151 – 196DisorderedSequence analysisAdd BLAST46
Regioni541 – 624DisorderedSequence analysisAdd BLAST84
Regioni1015 – 1040DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili391 – 411Sequence analysisAdd BLAST21
Coiled coili425 – 452Sequence analysisAdd BLAST28
Coiled coili508 – 528Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 63PolyampholyteSequence analysisAdd BLAST15
Compositional biasi74 – 96PolyampholyteSequence analysisAdd BLAST23
Compositional biasi103 – 117PolyampholyteSequence analysisAdd BLAST15
Compositional biasi154 – 196PolyampholyteSequence analysisAdd BLAST43
Compositional biasi585 – 599PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3639 Eukaryota
ENOG410XQVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155482

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR028928 CC2D2AN-C2
IPR041510 DUF5523

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF15625 CC2D2AN-C2, 1 hit
PF17661 DUF5523, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6YZ61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSDKFQDGG QQEVVEEEPE TNLLSLTARR GPRSLPPIPS ASRTGFAEFS
60 70 80 90 100
MRERMREKLQ AARSKAESAL LRDVPTPRPR RLRSPSREKE TETEFGTEPS
110 120 130 140 150
TEVQDTQKED DTKSYSRIKF RDSVRKIKSK PQLPPGFPSA EEAYNFFTFN
160 170 180 190 200
FDPEPEESEE KSPVKGGERA HHEDQEGEEG TQAQERAKKT EEEELLNGKD
210 220 230 240 250
AEDFLLGLDP TAHDFVAVRA AEYKSARIQL QKEKEILFTP SRLTVPTYKK
260 270 280 290 300
LPENIQPRFL EDEGLYIGAR PEVARTNENI MENRLLIQEP GSKWFGDDGR
310 320 330 340 350
ILALPSPIKP FPSRPSLTTR EQSPKAGLET LYKKAEKYVH SRQHMIGSGD
360 370 380 390 400
PPGNFQLDID ISGLIFTHHP CFSREHVLAS KLAQLYDQYL ARQQRNKTKF
410 420 430 440 450
LTDKLQALRK AVQTSLNPEK PHQSLDTTQK TINEYKSEIR QTRKLRDAEQ
460 470 480 490 500
EKDRTLLKTI IKVWKEMKSL REFQRFTNTP LKLVLRKEKV DPKLDEDAYE
510 520 530 540 550
AEIQAEIHEL LEEHMEEYAT KMEEYRTSHQ QWKAWRKAQR AKKKKKKQTT
560 570 580 590 600
EEHLEEEEAE ESFPEEEVTK PIPPEPTDPA VIEQQVRERA AHSRRRPGEP
610 620 630 640 650
TLIPELSLAG NVTPNDQCPR VEVSRREDVR RRSVYLKVVF NSKEVSRTVS
660 670 680 690 700
RPLGADFRVH FGQIFNLQIF NWPESLMLQV YETIGHSGTT LLAEVFLPIP
710 720 730 740 750
ETTLVTGRAP IEEVEFSSNQ HVTLDHEGVG SGVPFSFEAD GSNQLTLMTS
760 770 780 790 800
GKVSHSVAWA VGENGIPLIP PLSQQNIGFR SALRRADAIS SIGTSGLTDM
810 820 830 840 850
KKLAKWAAES KLDPNDPNHA PLMQLISVAT SGESYVPDFF RLEQLQQEFN
860 870 880 890 900
FVSEEELNRS KRFRLLHLRS QEVPEFRNYK QIPAYDREIM EKVFQDYEKR
910 920 930 940 950
LRDRNVIETK DHLDMHRATV AKYLQQVREA VVNRFLTAKH HFLLTDLVVE
960 970 980 990 1000
EEVPNISILG LSLFKLAEQK RPLRPRRKGR KKVTAQNLSD GDIKLLVNII
1010 1020 1030 1040 1050
RAYDIPVRKP VVSKFQQPSR SSRTFSEKQT ASPSTHSPLH NADYPLGQVL
1060 1070 1080 1090 1100
VRPFVEVSFQ RTICHTTTAE GPNPSWNEEL ELPFRAPNGD YSTASLQSVK
1110 1120 1130 1140 1150
DDVYINIFDE VLYDILEDDR ERGSGIHTRI ERHWLGCVKI PFSTIYFQAR
1160 1170 1180 1190 1200
IDGTFKIDIP PVLLGYSKER NIIMERAFDS ARSLSEGSYI TLFITIEPQL
1210 1220 1230 1240 1250
VPGEPMREKF DTQEDEKLLQ ATEKFQAECA LKFPQRQCLT TVTDMTGKTV
1260 1270 1280 1290 1300
FITRYLKPLN PPQELLHVYP NNPQATAELV ARYVSLIPFL PDSVSFAGVC
1310 1320 1330 1340 1350
DLWSTSDQFL DLLAGDEEEH AVLLCNYFLF LGKKAWLVMG SAIPEGPTAY
1360 1370 1380 1390 1400
VLTWEKNYYL IWNPCSGHCY GQFDAFCPLK SVGCLIGPDN IWFNIQHHDS
1410 1420 1430 1440 1450
PLRINFDVTK PKLWKSFFSR SLPYPGLSSV QPEELIYQHT DKAVAAELQD

RIEKILK
Length:1,457
Mass (Da):167,048
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFFE4247080D5034
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CFW7C2D2A_MOUSE
Coiled-coil and C2 domain-containin...
Cc2d2a
1,633Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1457Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC140277 Genomic DNA No translation available.
AC161536 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000125866; ENSMUSP00000114349; ENSMUSG00000039765

UCSC genome browser

More...
UCSCi
uc008xhs.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140277 Genomic DNA No translation available.
AC161536 Genomic DNA No translation available.

3D structure databases

SMRiF6YZ61
ModBaseiSearch...

Proteomic databases

PRIDEiF6YZ61

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50288 24 antibodies

Genome annotation databases

EnsembliENSMUST00000125866; ENSMUSP00000114349; ENSMUSG00000039765
UCSCiuc008xhs.1 mouse

Organism-specific databases

MGIiMGI:1924487 Cc2d2a

Phylogenomic databases

eggNOGiKOG3639 Eukaryota
ENOG410XQVY LUCA
GeneTreeiENSGT00940000155482

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cc2d2a mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039765 Expressed in retina and 226 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR000008 C2_dom
IPR028928 CC2D2AN-C2
IPR041510 DUF5523
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF15625 CC2D2AN-C2, 1 hit
PF17661 DUF5523, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6YZ61_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6YZ61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 22, 2015
Last modified: June 17, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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