UniProtKB - F6YYW0 (F6YYW0_HORSE)
Protein
Submitted name:
Gamma-aminobutyric acid type A receptor subunit gamma2
Gene
GABRG2
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- chloride channel activity Source: GO_Central
- GABA-A receptor activity Source: InterPro
- GABA-gated chloride ion channel activity Source: GO_Central
- inhibitory extracellular ligand-gated ion channel activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- gamma-aminobutyric acid signaling pathway Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- regulation of postsynaptic membrane potential Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: GO_Central
Keywordsi
Molecular function | Chloride channelARBA annotation, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Submitted name: Gamma-aminobutyric acid type A receptor subunit gamma2Imported |
Gene namesi | |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18202, GABRG2 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- dendrite membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- neuron projection Source: GO_Central
- postsynapse Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 41 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 53 – 72 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 84 – 106 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 201 – 220 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Membrane, Postsynaptic cell membraneARBA annotation, SynapseExpressioni
Gene expression databases
Bgeei | ENSECAG00000021414, Expressed in prefrontal cortex and 5 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 137 | Neur_chan_membInterPro annotationAdd BLAST | 113 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156685 |
HOGENOMi | CLU_010920_2_0_1 |
InParanoidi | F6YYW0 |
TreeFami | TF315453 |
Family and domain databases
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005437, GABBAg_rcpt IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA |
SUPFAMi | SSF90112, SSF90112, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6YYW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGDYVVMTV YFDLSRRMGY FTIQTYIPCT LIVVLSWVSF WINKDAVPAR
60 70 80 90 100
TSLGITTVLT MTTLSTIARK SLPKVSYVTA MDLFVSVCFI FVFSALVEYG
110 120 130 140 150
TLHYFVSNRK PSKDKDKKKK NPLLRMFSFK APTIDIRPRS ATIQMNNATH
160 170 180 190 200
LQERDEEYGY ECLDGKDCAS FFCCFEDCRT GAWRHGRIHI RIAKMDSYAR
210 220
IFFPTAFCLF NLVYWVSYLY L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HXZ1 | A0A3Q2HXZ1_HORSE | Gamma-aminobutyric acid type A rece... | GABRG2 LOC111772157 | 213 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000023153; ENSECAP00000019162; ENSECAG00000021414 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6YYW0 |
Genome annotation databases
Ensembli | ENSECAT00000023153; ENSECAP00000019162; ENSECAG00000021414 |
Organism-specific databases
VGNCi | VGNC:18202, GABRG2 |
Phylogenomic databases
GeneTreei | ENSGT00940000156685 |
HOGENOMi | CLU_010920_2_0_1 |
InParanoidi | F6YYW0 |
TreeFami | TF315453 |
Gene expression databases
Bgeei | ENSECAG00000021414, Expressed in prefrontal cortex and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005437, GABBAg_rcpt IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA |
SUPFAMi | SSF90112, SSF90112, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6YYW0_HORSE | |
Accessioni | F6YYW0Primary (citable) accession number: F6YYW0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |