UniProtKB - F6YTT0 (F6YTT0_HORSE)
Protein
Ankyrin repeat and SOCS box protein 8
Gene
ASB8
Organism
Equus caballus (Horse)
Status
Functioni
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.ARBA annotation
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- intracellular signal transduction Source: InterPro
- protein ubiquitination Source: UniProtKB-UniPathway
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat and SOCS box protein 8ARBA annotation |
Gene namesi | Name:ASB8Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:15575, ASB8 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022302, Expressed in gluteus medius and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 188 | ANK_REP_REGIONInterPro annotationAdd BLAST | 137 | |
Repeati | 52 – 84 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 85 – 116 | ANKPROSITE-ProRule annotationAdd BLAST | 32 | |
Repeati | 117 – 149 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 150 – 182 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 235 – 288 | SOCS boxInterPro annotationAdd BLAST | 54 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159366 |
HOGENOMi | CLU_000134_52_0_1 |
InParanoidi | F6YTT0 |
OMAi | EDSCFDL |
OrthoDBi | 896829at2759 |
TreeFami | TF332452 |
Family and domain databases
CDDi | cd03727, SOCS_ASB8, 1 hit |
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037332, ASB8_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50225, SOCS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6YTT0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT
60 70 80 90 100
HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC
110 120 130 140 150
VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN
160 170 180 190 200
NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLKGQTPISR LVALLVRGLG
210 220 230 240 250
TEKEDSCFEL LHRAVGHFEL RKNGTMPREV AKDQQLCEKL TVLCSAPGTL
260 270 280
KTLSRYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLVE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PZJ4 | A0A5F5PZJ4_HORSE | Ankyrin repeat and SOCS box contain... | ASB8 | 95 | Annotation score: |
Sequence databases
RefSeqi | XP_001490957.1, XM_001490907.5 XP_005611182.1, XM_005611125.2 |
Genome annotation databases
Ensembli | ENSECAT00000023832; ENSECAP00000019766; ENSECAG00000022302 |
GeneIDi | 100050927 |
KEGGi | ecb:100050927 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001490957.1, XM_001490907.5 XP_005611182.1, XM_005611125.2 |
3D structure databases
SMRi | F6YTT0 |
ModBasei | Search... |
Proteomic databases
PaxDbi | F6YTT0 |
Genome annotation databases
Ensembli | ENSECAT00000023832; ENSECAP00000019766; ENSECAG00000022302 |
GeneIDi | 100050927 |
KEGGi | ecb:100050927 |
Organism-specific databases
CTDi | 140461 |
VGNCi | VGNC:15575, ASB8 |
Phylogenomic databases
GeneTreei | ENSGT00940000159366 |
HOGENOMi | CLU_000134_52_0_1 |
InParanoidi | F6YTT0 |
OMAi | EDSCFDL |
OrthoDBi | 896829at2759 |
TreeFami | TF332452 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Gene expression databases
Bgeei | ENSECAG00000022302, Expressed in gluteus medius and 22 other tissues |
Family and domain databases
CDDi | cd03727, SOCS_ASB8, 1 hit |
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037332, ASB8_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6YTT0_HORSE | |
Accessioni | F6YTT0Primary (citable) accession number: F6YTT0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |