UniProtKB - F6YP00 (F6YP00_HORSE)
Protein
Submitted name:
Seizure related 6 homolog like
Gene
SEZ6L
Organism
Equus caballus (Horse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- cerebellar Purkinje cell layer development Source: Ensembl
- regulation of protein kinase C signaling Source: Ensembl
- synapse maturation Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Seizure related 6 homolog likeImported |
Gene namesi | Name:SEZ6LImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:22883, SEZ6L |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 959 – 981 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_5018616433 | 31 – 1026 | Sequence analysisAdd BLAST | 996 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 283 ↔ 310 | PROSITE-ProRule annotation | ||
Disulfide bondi | 454 ↔ 481 | PROSITE-ProRule annotation | ||
Disulfide bondi | 775 ↔ 802 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PaxDbi | F6YP00 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023630, Expressed in prefrontal cortex and 7 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 283 – 391 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 393 – 452 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 454 – 564 | CUBInterPro annotationAdd BLAST | 111 | |
Domaini | 567 – 628 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 630 – 741 | CUBInterPro annotationAdd BLAST | 112 | |
Domaini | 745 – 804 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 806 – 869 | SushiInterPro annotationAdd BLAST | 64 | |
Domaini | 873 – 934 | SushiInterPro annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 205 | DisorderedSequence analysisAdd BLAST | 179 | |
Regioni | 217 – 262 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 75 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 169 – 192 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 222 – 237 | Pro-richSequence analysisAdd BLAST | 16 |
Keywords - Domaini
SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158873 |
HOGENOMi | CLU_011474_1_0_1 |
InParanoidi | F6YP00 |
TreeFami | TF330037 |
Family and domain databases
CDDi | cd00033, CCP, 5 hits cd00041, CUB, 3 hits |
Gene3Di | 2.60.120.290, 3 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00084, Sushi, 5 hits |
SMARTi | View protein in SMART SM00032, CCP, 5 hits SM00042, CUB, 3 hits |
SUPFAMi | SSF49854, SSF49854, 3 hits SSF57535, SSF57535, 5 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 3 hits PS50923, SUSHI, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F6YP00-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAARPPTAG LGGTSLLLAL LLGSPAAALA GDGPPEGDAS PPGTYLMPSG
60 70 80 90 100
ALGSSSLSQE SREERVTTAS PNPAQSGEEG REPELEGTAP SAHQDPAALA
110 120 130 140 150
TLLPEEAATK QAFPPRKKLP SLQQVNLARK QLRPKATSAA ALQRAGSQPA
160 170 180 190 200
SPGLGVLSSA TEKPRPPGDP DPSTSEETRR PSEEEPLWLD RKEGEGPTTP
210 220 230 240 250
APLQISPFTA QPYVAHTLPQ RPAPGEPAPP EEAPEAPPED ASPMTLMDKG
260 270 280 290 300
ENDLTGSASE ETTTSTIITT TTVITTEQAP ALCSVSFSDP EGYIDSGDYP
310 320 330 340 350
PLPLSNFLEC TYNVTVYTGY GVELQVKSVN LSEGELLSIR GVDGPTLTVL
360 370 380 390 400
ANQTLLVEGQ VIRSPTNTIS VYFRTFQDDG LGTFQLHYQA FMLSCNFPRR
410 420 430 440 450
PDYGDVTVMD LHSGGVAHFH CHLGYELQGA KTLTCINASK PHWSSQEPIC
460 470 480 490 500
SAPCGGAVHN ATIGRVLSPS HPGNTNGGQF CVWTIEAPEG QKLHLHFERL
510 520 530 540 550
SLHEKDRMMV YSGLTNKSAL LYDSLQIESV PFEGLLSEGN SIRIEFTSDQ
560 570 580 590 600
PQVASAFNIR FEAFEKGHCY EPYIQNGNFT TSDPTYNIGT TVEFTCDPGH
610 620 630 640 650
SLEQGPAVIE CINVRDPYWN DTEPLCRAMC GGELSAVAGV VLSPNWPEPY
660 670 680 690 700
VEGEDCIWKI HVGEEKRIFL DIQFLNLSNS DILTIYDGDE VMPHILGQYL
710 720 730 740 750
GNSGPQKLYS STPDLTIQFH SDPAGLIFGK GQGFIMNYIE VSRNDSCSDL
760 770 780 790 800
PEIQNGWKTT SHTELVRGAR ITYQCDPGYD IVGSDTLTCQ WDLSWSSDPP
810 820 830 840 850
FCEKIMYCTD PGEVDHSTRL ISDPVLLVGT TIQYTCNPGF VLEGSSLLTC
860 870 880 890 900
YSRETGTPIW TSRLPHCVSE ESLACDNPGL PENGYQILYK RLYLPGESLT
910 920 930 940 950
FMCYEGFELM GEVTIRCILG QPSHWNGPLP VCKVNQDSFE HALEVAEAAA
960 970 980 990 1000
ETSLEGGNMA LAIFIPVLII SLLLGGAYIY ITRCRYYSNL RLPLMYSHPY
1010 1020
SQITVETEFD NPIYETGETR EYEVSI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PIE4 | A0A5F5PIE4_HORSE | Seizure related 6 homolog like | SEZ6L | 962 | Annotation score: | ||
A0A5F5PP68 | A0A5F5PP68_HORSE | Seizure related 6 homolog like | SEZ6L | 1,015 | Annotation score: | ||
A0A5F5PTD3 | A0A5F5PTD3_HORSE | Seizure related 6 homolog like | SEZ6L | 950 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000025486; ENSECAP00000021202; ENSECAG00000023630 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6YP00 |
Genome annotation databases
Ensembli | ENSECAT00000025486; ENSECAP00000021202; ENSECAG00000023630 |
Organism-specific databases
VGNCi | VGNC:22883, SEZ6L |
Phylogenomic databases
GeneTreei | ENSGT00940000158873 |
HOGENOMi | CLU_011474_1_0_1 |
InParanoidi | F6YP00 |
TreeFami | TF330037 |
Gene expression databases
Bgeei | ENSECAG00000023630, Expressed in prefrontal cortex and 7 other tissues |
Family and domain databases
CDDi | cd00033, CCP, 5 hits cd00041, CUB, 3 hits |
Gene3Di | 2.60.120.290, 3 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00084, Sushi, 5 hits |
SMARTi | View protein in SMART SM00032, CCP, 5 hits SM00042, CUB, 3 hits |
SUPFAMi | SSF49854, SSF49854, 3 hits SSF57535, SSF57535, 5 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 3 hits PS50923, SUSHI, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6YP00_HORSE | |
Accessioni | F6YP00Primary (citable) accession number: F6YP00 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |