UniProtKB - F6YLX1 (F6YLX1_MACMU)
Protein
Tyrosine-protein kinase
Gene
JAK1
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.2UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 908 | ATPUniRule annotation | 1 | |
Active sitei | 1003 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 881 – 889 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- growth hormone receptor binding Source: GO_Central
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-UniRule
- protein phosphatase binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- interleukin-2-mediated signaling pathway Source: Ensembl
- intracellular signal transduction Source: InterPro
- positive regulation of homotypic cell-cell adhesion Source: Ensembl
- positive regulation of sprouting angiogenesis Source: Ensembl
- protein localization to cell-cell junction Source: Ensembl
- response to antibiotic Source: Ensembl
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:JAK1Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:73810, JAK1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: UniProtKB-UniRule
Nucleus
- nucleus Source: Ensembl
Other locations
Expressioni
Gene expression databases
Bgeei | ENSMMUG00000018566, Expressed in spleen and 23 other tissues |
Interactioni
GO - Molecular functioni
- growth hormone receptor binding Source: GO_Central
- protein phosphatase binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000024423 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 420 | FERMInterPro annotationAdd BLAST | 387 | |
Domaini | 439 – 544 | SH2InterPro annotationAdd BLAST | 106 | |
Domaini | 583 – 855 | Protein kinaseInterPro annotationAdd BLAST | 273 | |
Domaini | 875 – 1153 | Protein kinaseInterPro annotationAdd BLAST | 279 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 334 – 358 | Sequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157092 |
HOGENOMi | CLU_008155_1_0_1 |
TreeFami | TF327041 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020776, Tyr_kinase_non-rcpt_Jak1 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01824, JANUSKINASE1 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6YLX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE VPEPGVEVIF YMSDREPLRL
60 70 80 90 100
GSGEYTAEEL CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK
110 120 130 140 150
MSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KKVPDATPLL
160 170 180 190 200
DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
210 220 230 240 250
AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
260 270 280 290 300
FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN
310 320 330 340 350
WFHSNDSGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH
360 370 380 390 400
KKDEEKNKIR EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE
410 420 430 440 450
EALSFVSLVD GYFRLTADAH HYLCTDVAPP LIVHNIQNGC HGPICTEYAI
460 470 480 490 500
NKLRQEGSEE GMYVLRWSCT DFDNILMTVT CFEKSEQGQG AQKQFKNFQI
510 520 530 540 550
EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML KRCCQPKPRE
560 570 580 590 600
ISNLLVATKK AQEWQPVYPM SQLSFDRIFK KDLVQGEHLG RGTRTHIYSG
610 620 630 640 650
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI
660 670 680 690 700
VYLYGVCVRD VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS
710 720 730 740 750
ALSYLEDKDL VHGNVCTKNL LLAREGIDSE CGPFIKLSDP GIPITVLSRQ
760 770 780 790 800
ECIERIPWIA PECVEDSKNL SVAADKWSFG TTLWEICYNG EIPLKDKTLI
810 820 830 840 850
EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA IMRDINKLEE
860 870 880 890 900
QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN
910 920 930 940 950
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN
960 970 980 990 1000
GIKLIMEFLP SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV
1010 1020 1030 1040 1050
HRDLAARNVL VESEHQVKIG DFGLTKAIET DKEYYTVKDD RDSPVFWYAP
1060 1070 1080 1090 1100
ECLMQSKFYI ASDVWSFGVT LHELLTYCDS DSSPMALFLK MIGPTHGQMT
1110 1120 1130 1140 1150
VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT SFQNLIEGFE
ALLK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F7ZH35 | A0A5F7ZH35_MACMU | Tyrosine-protein kinase | JAK1 | 1,054 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU322240 mRNA Translation: AFE65996.1 JU471172 mRNA Translation: AFH27976.1 JV044982 mRNA Translation: AFI35053.1 |
RefSeqi | NP_001244838.1, NM_001257909.1 |
Genome annotation databases
Ensembli | ENSMMUT00000026100; ENSMMUP00000024423; ENSMMUG00000018566 |
GeneIDi | 677689 |
KEGGi | mcc:677689 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU322240 mRNA Translation: AFE65996.1 JU471172 mRNA Translation: AFH27976.1 JV044982 mRNA Translation: AFI35053.1 |
RefSeqi | NP_001244838.1, NM_001257909.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000024423 |
Genome annotation databases
Ensembli | ENSMMUT00000026100; ENSMMUP00000024423; ENSMMUG00000018566 |
GeneIDi | 677689 |
KEGGi | mcc:677689 |
Organism-specific databases
CTDi | 3716 |
VGNCi | VGNC:73810, JAK1 |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000157092 |
HOGENOMi | CLU_008155_1_0_1 |
TreeFami | TF327041 |
Gene expression databases
Bgeei | ENSMMUG00000018566, Expressed in spleen and 23 other tissues |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR019748, FERM_central IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020776, Tyr_kinase_non-rcpt_Jak1 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01824, JANUSKINASE1 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6YLX1_MACMU | |
Accessioni | F6YLX1Primary (citable) accession number: F6YLX1 Secondary accession number(s): H9EUD7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | November 30, 2016 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |