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Protein

O-acyltransferase

Gene

SOAT1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei461UniRule annotation1

GO - Molecular functioni

  • cholesterol binding Source: Ensembl
  • cholesterol O-acyltransferase activity Source: GO_Central
  • fatty-acyl-CoA binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
O-acyltransferaseUniRule annotation
Gene namesi
Name:SOAT1Imported
OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei143 – 164HelicalSequence analysisAdd BLAST22
Transmembranei185 – 204HelicalSequence analysisAdd BLAST20
Transmembranei224 – 246HelicalSequence analysisAdd BLAST23
Transmembranei321 – 342HelicalSequence analysisAdd BLAST22
Transmembranei362 – 390HelicalSequence analysisAdd BLAST29
Transmembranei447 – 465HelicalSequence analysisAdd BLAST19
Transmembranei471 – 490HelicalSequence analysisAdd BLAST20
Transmembranei502 – 521HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSOANG00000000960 Expressed in 7 organ(s), highest expression level in female gonad

Interactioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000001515

Family & Domainsi

Sequence similaritiesi

Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
InParanoidiF6YHF4
KOiK00637
OrthoDBiEOG091G0991
TreeFamiTF105767

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

Sequencei

Sequence statusi: Complete.

F6YHF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGEEKPSVR NRRLNSSTYE TLEKDENQRR PEEEVTQTLN NGRLDIQQLI
60 70 80 90 100
RKKIQLTAEA EQLKPVFMKE VDNYFDEFVT SLIEKSTSLD SCNPSATSFS
110 120 130 140 150
TLSERKEHHR IKELRAPPEH GKIFVSRRSL LDELFEVDHI RTIYHMFIAL
160 170 180 190 200
LILFILSTLV VDYIDEGRLV LEFNLLSYAF GKFPTVIWAW WTMFLSTLTI
210 220 230 240 250
PYVLFQQWAK GYPKSSYPVI YSLFYGLLFM VFQIIGLGCG PTYVVLAYSL
260 270 280 290 300
PPASRFIVIL EQVRFVMKAH SFVRENVPRV LASIKEKSNV PIPQVNQYLY
310 320 330 340 350
FLFAPTLIYR DSYPRTATIR WSYVATKFAQ VFGCLFYVYY IFERLCAPLF
360 370 380 390 400
RNIKQEPFSM RVLVLCVFNS ILPGVLIFFL AFFAFLHCWL NAFAEMLRFG
410 420 430 440 450
DRMFYKDWWN STSYANYYRT WNVVVHDWLY YYAYQDFLWF FSKRFKAAAM
460 470 480 490 500
LSVFAVSAVV HEYALALCLS FFYPVLFVLF MFFGMAFNFI VNDRRKRPIW
510 520 530 540 550
NVMMWTSIFL GQGVILCFYS QEWYARQHCP LKNPTFLDYI RPRSWTCRYQ

F
Length:551
Mass (Da):65,464
Last modified:January 9, 2013 - v2
Checksum:i043A382252595A9A
GO

Sequence databases

RefSeqiXP_007667124.1, XM_007668934.1
XP_007667125.1, XM_007668935.1
XP_007667126.1, XM_007668936.1

Genome annotation databases

EnsembliENSOANT00000001516; ENSOANP00000001515; ENSOANG00000000960
GeneIDi100085367
KEGGioaa:100085367

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_007667124.1, XM_007668934.1
XP_007667125.1, XM_007668935.1
XP_007667126.1, XM_007668936.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000001515

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOANT00000001516; ENSOANP00000001515; ENSOANG00000000960
GeneIDi100085367
KEGGioaa:100085367

Organism-specific databases

CTDi6646

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
InParanoidiF6YHF4
KOiK00637
OrthoDBiEOG091G0991
TreeFamiTF105767

Gene expression databases

BgeeiENSOANG00000000960 Expressed in 7 organ(s), highest expression level in female gonad

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6YHF4_ORNAN
AccessioniPrimary (citable) accession number: F6YHF4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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