UniProtKB - F6YG22 (F6YG22_HORSE)
Protein
Diacylglycerol kinase
Gene
DGKE
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- EC:2.7.1.107UniRule annotation
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- diacylglycerol kinase activity Source: UniProtKB-EC
- NAD+ kinase activity Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | KinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding, ZincARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)Short name: DAG kinaseUniRule annotation |
Gene namesi | Name:DGKEImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:17149, DGKE |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000021851, Expressed in testis and 23 other tissues |
ExpressionAtlasi | F6YG22, baseline |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 548 – 568 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000158604 |
HOGENOMi | CLU_003770_3_1_1 |
InParanoidi | F6YG22 |
OrthoDBi | 1275907at2759 |
TreeFami | TF313104 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6YG22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGEKRPAPS EGLFADGHLV LWTLCSVLLP VFITFWCSLQ RSRRQLHRRD
60 70 80 90 100
IFRKSKHGWR DTDLFSQPTY CCVCAQHILQ GAFCDCCGLC VDEGCLKNAD
110 120 130 140 150
RRFQCKEIML KNEGRALDAM PHHWIRGNVP LCSYCVVCKQ QCGTQPKLCD
160 170 180 190 200
YRCIWCQKTV HDECMKNSLR NEECDFGEFK NLIIPPSYLT SINQMRKDKK
210 220 230 240 250
TDYALLASKL GKQWAPLIIL ANSRSGTNMG EGLLGEFRIL LNPVQVFDVT
260 270 280 290 300
KTPPIKALQL CTLLPCYSAR VLVCGGDGTV GWVLDAIDEM KIKGQEEYIP
310 320 330 340 350
QVAVLPLGTG NDLSNTLGWG TGYAGEIPVA QVLRNVMEAD GIKLDRWKVQ
360 370 380 390 400
VTNKGYYHLR KPKEFTMNNY FSVGPDALMA LNFHAHREKA PSLFSSRILN
410 420 430 440 450
KAVYLFYGTK DCLVQECKDL NKKVELELDG ERVELPNLEG IIVLNIGYWG
460 470 480 490 500
GGCRLWEGMG DETYPLARHD DGLLEVVGVY GSFHCAQIQV KLANPFRIGQ
510 520 530 540 550
AHTVRLILKC SMMPMQVDGE PWAQGPCTVT ITHKTHALML YFSGEQTDDD
560
ISSASDQEDP LPDLSRRC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HZI7 | A0A3Q2HZI7_HORSE | Diacylglycerol kinase | DGKE | 603 | Annotation score: | ||
A0A3Q2L4Y1 | A0A3Q2L4Y1_HORSE | Diacylglycerol kinase | DGKE | 588 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000023473; ENSECAP00000019443; ENSECAG00000021851 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6YG22 |
Genome annotation databases
Ensembli | ENSECAT00000023473; ENSECAP00000019443; ENSECAG00000021851 |
Organism-specific databases
VGNCi | VGNC:17149, DGKE |
Phylogenomic databases
GeneTreei | ENSGT00940000158604 |
HOGENOMi | CLU_003770_3_1_1 |
InParanoidi | F6YG22 |
OrthoDBi | 1275907at2759 |
TreeFami | TF313104 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
Gene expression databases
Bgeei | ENSECAG00000021851, Expressed in testis and 23 other tissues |
ExpressionAtlasi | F6YG22, baseline |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR037607, DGK IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6YG22_HORSE | |
Accessioni | F6YG22Primary (citable) accession number: F6YG22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |