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Entry version 51 (12 Aug 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Fibronectin type III domain containing 3A

Gene

FNDC3A

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fibronectin type III domain containing 3AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC3AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:58568, FNDC3A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1118 – 1141HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6YD83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000023697, Expressed in testis and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6YD83, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 313Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini317 – 409Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini413 – 506Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini510 – 604Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini608 – 701Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini705 – 795Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini805 – 894Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini895 – 989Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini990 – 1095Fibronectin type-IIIInterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 199DisorderedSequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 142PolyampholyteSequence analysisAdd BLAST31
Compositional biasi143 – 182PolarSequence analysisAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159319

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004152_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6YD83

TreeFam database of animal gene trees

More...
TreeFami
TF316401

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F6YD83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPAQVPMM SPNGSVPPIY MPPGYAPQVI EDNGVRRVVV VPQAPEFHPG
60 70 80 90 100
GHTVIHRSPH PPLPGFIPVP TMMPPPPRHM YSPVTAAGDM TTQYMPQYQS
110 120 130 140 150
SQVYGDVDAH STHGRSNFRD ERSSKTYERL QKKLKDRQGT QKDKMSSPPS
160 170 180 190 200
SPQKCPSPIN EHNGLTKGQN AGGINTGSVK SKSGRGKGGA QIDTELEEKD
210 220 230 240 250
EETKAFEALL SNIIKPVASD IQARTVILTW SPPSNFINGE TDETTVPELY
260 270 280 290 300
GYEILVSSTG KDGKYKSVYA GEETSVTLND LKPATDYHAK VQAEYNSIKG
310 320 330 340 350
TPSEAESFTT LSCEPDVPNP PRIANRTKNS LTLQWKAPSD NGSKIQSFIL
360 370 380 390 400
EWDEGKGNGE FCQCYMGSQK QFKITKLSPA MGCKFRLSAK NDYGTSGFSE
410 420 430 440 450
EVLYYTSGCA PSMPASPVLT KAGVTWLSLQ WSKPLGTPSD EGISYILEME
460 470 480 490 500
EETSGYGFKP KYDGEDLAYT VKNLRRSTKY KFKVIAYNSE GKSNPSEIVE
510 520 530 540 550
FTTCPDKPGV PVKPSVKGKI HSHSFKITWD PPKDNGGAAI NKYVVEMAEG
560 570 580 590 600
PNGNKWDMIY SGATREHLCD RLNPGCFYRL RVYCISDGGQ SAVSESLLVQ
610 620 630 640 650
TPAVPPGPCL PPRLQGRPKA KEIQLRWGPP LVDGGSPIYC YDVEMSPVEK
660 670 680 690 700
DEPREVYQGS EVECTVSNLL PGKTYSFRLR AANKIGFGPF SEKCEITTAP
710 720 730 740 750
GPPDQCKPPQ VTCKSATCAQ VNWEVPLSNG TDVTEYRLEW GGVEGSMQIC
760 770 780 790 800
YCGPGLSYEL KGLSPATTYY CRVQALSIVG PGPFSEVVAC VTPPSVPAIV
810 820 830 840 850
TCLQEISDDE IEDPHYSPST CLAISWGKPC DHGSEILAYS IDCGDKQPLT
860 870 880 890 900
VGKVTSYIID NLQPDTTYRI RIQALNSLGA GPFSHMIKLK TKPLPPDPPR
910 920 930 940 950
LECVAFSHQN LKLKWGEGTP RTLSTDSIQY HLQMEDKNGR FVSLYRGPCH
960 970 980 990 1000
TYKVQRLSES TSYKFCIQAC NEAGEGPLSQ EYIFTTPKSV PAALKAPKIE
1010 1020 1030 1040 1050
KVNDHICEIT WECLQPMKGD PVIYSLQVMV GKDSEFKQIY KGPDSSFRYS
1060 1070 1080 1090 1100
SLQLNCEYRF RVCAIRQCQD PVGHQDLVGP YSTTVLFISQ RTEPPASTNR
1110 1120 1130 1140
DTVESTRTRR ALSDEQCAAV ILVLFAFFSI LIAFIIQYFV IK
Length:1,142
Mass (Da):125,774
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29DFF5D5C2DEAF01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HTM1A0A3Q2HTM1_HORSE
Fibronectin type III domain contain...
FNDC3A
1,198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2IDI7A0A3Q2IDI7_HORSE
Fibronectin type III domain contain...
FNDC3A
1,169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HS70A0A3Q2HS70_HORSE
Fibronectin type III domain contain...
FNDC3A
1,147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2LDN2A0A3Q2LDN2_HORSE
Fibronectin type III domain contain...
FNDC3A
1,108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000025676; ENSECAP00000021371; ENSECAG00000023697

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6YD83

Genome annotation databases

EnsembliENSECAT00000025676; ENSECAP00000021371; ENSECAG00000023697

Organism-specific databases

VGNCiVGNC:58568, FNDC3A

Phylogenomic databases

GeneTreeiENSGT00940000159319
HOGENOMiCLU_004152_0_0_1
InParanoidiF6YD83
TreeFamiTF316401

Gene expression databases

BgeeiENSECAG00000023697, Expressed in testis and 22 other tissues
ExpressionAtlasiF6YD83, baseline

Family and domain databases

CDDicd00063, FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00041, fn3, 7 hits
SMARTiView protein in SMART
SM00060, FN3, 9 hits
SUPFAMiSSF49265, SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6YD83_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6YD83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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